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Large Language Models (LLMs) have greatly pushed forward advancements in natural language processing, yet their high memory and computational demands hinder practical deployment. Binarization, as an effective compression technique, can…

Computer Vision and Pattern Recognition · Computer Science 2026-02-02 Zhiteng Li , Xianglong Yan , Tianao Zhang , Haotong Qin , Dong Xie , Jiang Tian , zhongchao shi , Linghe Kong , Yulun Zhang , Xiaokang Yang

The size of a model has been a strong predictor of its quality, as well as its cost. As such, the trade-off between model cost and quality has been well-studied. Post-training optimizations like quantization and pruning have typically…

Machine Learning · Computer Science 2025-08-29 Giuseppe Franco , Pablo Monteagudo-Lago , Ian Colbert , Nicholas Fraser , Michaela Blott

At present, the quantification methods of neural network models are mainly divided into post-training quantization (PTQ) and quantization aware training (QAT). Post-training quantization only need a small part of the data to complete the…

Machine Learning · Computer Science 2022-07-08 Huabin Diao , Gongyan Li , Shaoyun Xu , Yuexing Hao

Protein language models (pLMs) produce per-residue representations that capture evolutionary and structural information, yet their mean-pooled sequence embeddings are not explicitly trained to reflect functional, evolutionary or structural…

Machine Learning · Computer Science 2026-05-11 Dan Ofer , Oriel Perets , Michal Linial , Nadav Rappoport

Deploying large language models (LLMs) is challenging due to their massive parameters and high computational costs. Ultra low-bit quantization can significantly reduce storage and accelerate inference, but extreme compression (i.e., mean…

Post-training quantization (PTQ) is a technique used to optimize and reduce the memory footprint and computational requirements of machine learning models. It has been used primarily for neural networks. For Brain-Computer Interfaces (BCI)…

Human-Computer Interaction · Computer Science 2024-10-11 Hubert Cecotti , Dalvir Dhaliwal , Hardip Singh , Yogesh Kumar Meena

Serving Large Language Models (LLMs) is costly. However, post-training weight quantization can address this problem by both compressing their sizes for limited memory and saving bandwidth for acceleration. As not all weight dimensions are…

Machine Learning · Computer Science 2025-03-05 Yuezhou Hu , Weiyu Huang , Zichen Liang , Chang Chen , Jintao Zhang , Jun Zhu , Jianfei Chen

Post-training quantization (PTQ) reduces the memory footprint of LLMs by quantizing their weights to low-precision. In this work, we introduce QuIP#, a weight-only PTQ method that achieves state-of-the-art results in extreme compression…

Machine Learning · Computer Science 2024-06-05 Albert Tseng , Jerry Chee , Qingyao Sun , Volodymyr Kuleshov , Christopher De Sa

While protein language models (pLMs) have transformed biological research, the scaling laws governing their improvement remain underexplored. By adapting methodologies from NLP scaling laws, we investigated the optimal ratio between model…

Biomolecules · Quantitative Biology 2024-06-27 Yaiza Serrano , Álvaro Ciudad , Alexis Molina

We introduce a protein language model for determining the complete sequence of a peptide based on measurement of a limited set of amino acids. To date, protein sequencing relies on mass spectrometry, with some novel edman degregation based…

Deploying large language models (LLMs) on mobile platforms faces significant challenges due to the limited memory and shared computational resources of the device. Resource availability may be an issue as it is directly impacted by the…

Post-Training Quantization (PTQ) is crucial for efficient model deployment, yet its effectiveness on Ascend NPU remains under-explored compared to GPU architectures. This paper presents a case study of representative PTQ baselines applied…

Machine Learning · Computer Science 2026-02-23 Yuchen Luo , Fangyue Zhu , Ruining Zhou , Mingzhe Huang , Jian Zhu , Fanyu Fan , Wei Shao

Large language models (LLMs) excel at natural language tasks but face deployment challenges due to their growing size outpacing GPU memory advancements. Model quantization mitigates this issue by lowering weight and activation precision,…

Computation and Language · Computer Science 2025-12-17 Shizhuo Mao , Song Chen , Yi Kang

Learning effective protein representations is critical in a variety of tasks in biology such as predicting protein functions. Recent sequence representation learning methods based on Protein Language Models (PLMs) excel in sequence-based…

Quantitative Methods · Quantitative Biology 2023-10-19 Zuobai Zhang , Chuanrui Wang , Minghao Xu , Vijil Chenthamarakshan , Aurélie Lozano , Payel Das , Jian Tang

Post-training quantization (PTQ) enables efficient deployment of large language models by mapping pretrained weights to low-bit formats without retraining, typically using a small calibration set to minimize a layer-wise calibration…

Machine Learning · Computer Science 2026-05-12 Seohyeon Cha , Huancheng Chen , Dongjun Kim , Haoran Zhang , Kevin Chan , Gustavo de Veciana , Haris Vikalo

Diffusion models have achieved great success in image synthesis through iterative noise estimation using deep neural networks. However, the slow inference, high memory consumption, and computation intensity of the noise estimation model…

Computer Vision and Pattern Recognition · Computer Science 2023-06-09 Xiuyu Li , Yijiang Liu , Long Lian , Huanrui Yang , Zhen Dong , Daniel Kang , Shanghang Zhang , Kurt Keutzer

In the quest for next-generation sequence modeling architectures, State Space Models (SSMs) have emerged as a potent alternative to transformers, particularly for their computational efficiency and suitability for dynamical systems. This…

Machine Learning · Computer Science 2024-06-17 Steven Abreu , Jens E. Pedersen , Kade M. Heckel , Alessandro Pierro

Deployment of Large Language Models (LLMs) has major computational costs, due to their rapidly expanding size. Compression of LLMs reduces the memory footprint, latency, and energy required for their inference. Post-training Quantization…

Machine Learning · Computer Science 2025-05-07 Ali Edalati , Alireza Ghaffari , Mahsa Ghazvini Nejad , Lu Hou , Boxing Chen , Masoud Asgharian , Vahid Partovi Nia

Protein language models (PLMs) have emerged as powerful tools to detect complex patterns of protein sequences. However, the capability of PLMs to fully capture information on protein sequences might be limited by focusing on single…

Machine Learning · Computer Science 2025-05-27 Hazem Alsamkary , Mohamed Elshaffei , Mohamed Elkerdawy , Ahmed Elnaggar

Post-training quantization (PTQ) is a popular method for compressing deep neural networks (DNNs) without modifying their original architecture or training procedures. Despite its effectiveness and convenience, the reliability of PTQ methods…

Machine Learning · Computer Science 2023-03-24 Zhihang Yuan , Jiawei Liu , Jiaxiang Wu , Dawei Yang , Qiang Wu , Guangyu Sun , Wenyu Liu , Xinggang Wang , Bingzhe Wu