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Large language models (LLMs) achieve impressive performance across domains but face significant challenges when deployed on consumer-grade GPUs or personal devices such as laptops, due to high memory consumption and inference costs.…

Machine Learning · Computer Science 2026-02-02 Li Lin , Xinyu Hu , Xiaojun Wan

Post-training quantization (PTQ) has emerged as a widely adopted technique for compressing and accelerating Large Language Models (LLMs). The major challenge in LLM quantization is that uneven and heavy-tailed data distributions can expand…

Machine Learning · Computer Science 2025-01-27 Xing Hu , Yuan Cheng , Dawei Yang , Zukang Xu , Zhihang Yuan , Jiangyong Yu , Chen Xu , Zhe Jiang , Sifan Zhou

The rapid scaling of Protein Language Models (PLMs) has unlocked unprecedented accuracy in protein structure prediction and design, but the quadratic memory growth of the Key-Value (KV) cache during inference remains a prohibitive barrier…

Quantitative Methods · Quantitative Biology 2026-03-30 Yue Hu , Junqing Wang , Yingchao Liu

We explore optimally training protein language models, an area of significant interest in biological research where guidance on best practices is limited. Most models are trained with extensive compute resources until performance gains…

Machine Learning · Computer Science 2024-11-05 Xingyi Cheng , Bo Chen , Pan Li , Jing Gong , Jie Tang , Le Song

Latent Diffusion Models (LDMs) capture the dynamic evolution of latent variables over time, blending patterns and multimodality in a generative system. Despite the proficiency of LDM in various applications, such as text-to-image…

Computer Vision and Pattern Recognition · Computer Science 2023-12-12 Yuewei Yang , Xiaoliang Dai , Jialiang Wang , Peizhao Zhang , Hongbo Zhang

Weight-only quantization has become a standard approach for efficiently serving large language models (LLMs). However, existing methods fail to efficiently compress models to binary (1-bit) levels, as they either require large amounts of…

Machine Learning · Computer Science 2026-05-19 Hyochan Chong , Dongkyu Kim , Changdong Kim , Minseop Choi

This paper introduces a post-training quantization~(PTQ) method achieving highly efficient Convolutional Neural Network~ (CNN) quantization with high performance. Previous PTQ methods usually reduce compression error via performing…

Computer Vision and Pattern Recognition · Computer Science 2022-01-19 Chen Lin , Zheyang Li , Bo Peng , Haoji Hu , Wenming Tan , Ye Ren , Shiliang Pu

We propose LLM-FP4 for quantizing both weights and activations in large language models (LLMs) down to 4-bit floating-point values, in a post-training manner. Existing post-training quantization (PTQ) solutions are primarily integer-based…

Computation and Language · Computer Science 2024-04-30 Shih-yang Liu , Zechun Liu , Xijie Huang , Pingcheng Dong , Kwang-Ting Cheng

Large transformer models have demonstrated remarkable success. Post-training quantization (PTQ), which requires only a small dataset for calibration and avoids end-to-end retraining, is a promising solution for compressing these large…

Machine Learning · Computer Science 2024-02-09 Zhikai Li , Xuewen Liu , Jing Zhang , Qingyi Gu

In this paper, we propose a post-training quantization framework of large vision-language models (LVLMs) for efficient multi-modal inference. Conventional quantization methods sequentially search the layer-wise rounding functions by…

Computer Vision and Pattern Recognition · Computer Science 2025-02-25 Changyuan Wang , Ziwei Wang , Xiuwei Xu , Yansong Tang , Jie Zhou , Jiwen Lu

Large Language Models (LLMs) have shown an impressive capability in code generation. The LLM effectiveness generally increases with its size: The higher the number of LLM's trainable parameters the better its ability to implement code.…

Software Engineering · Computer Science 2026-01-28 Alessandro Giagnorio , Antonio Mastropaolo , Saima Afrin , Massimiliano Di Penta , Gabriele Bavota

Denoising diffusion models have emerged as state-of-the-art in generative tasks across image, audio, and video domains, producing high-quality, diverse, and contextually relevant data. However, their broader adoption is limited by high…

Sound · Computer Science 2024-09-24 Jayneel Vora , Aditya Krishnan , Nader Bouacida , Prabhu RV Shankar , Prasant Mohapatra

Large language models (LLMs) have shown remarkable capabilities in various tasks. However their huge model size and the consequent demand for computational and memory resources also pose challenges to model deployment. Currently, 4-bit…

Machine Learning · Computer Science 2023-12-08 Jiayi Pan , Chengcan Wang , Kaifu Zheng , Yangguang Li , Zhenyu Wang , Bin Feng

Reasoning models excel at complex tasks such as coding and mathematics, yet their inference is often slow and token-inefficient. To improve the inference efficiency, post-training quantization (PTQ) usually comes with the cost of large…

Machine Learning · Computer Science 2026-01-22 Keyu Lv , Manyi Zhang , Xiaobo Xia , Jingchen Ni , Shannan Yan , Xianzhi Yu , Lu Hou , Chun Yuan , Haoli Bai

Large language models (LLMs) have wide applications in the field of natural language processing(NLP), such as GPT-4 and Llama. However, with the exponential growth of model parameter sizes, LLMs bring significant resource overheads. Low-bit…

Computation and Language · Computer Science 2025-02-27 Liangdong Liu , Zhitong Zheng , Cong Wang , Tianhuang Su , Zhenyu Yang

Large Language Models (LLMs) offer powerful capabilities, but their significant size and computational requirements hinder deployment on resource-constrained mobile devices. This paper investigates Post-Training Quantization (PTQ) for…

Machine Learning · Computer Science 2025-12-09 Agatsya Yadav , Renta Chintala Bhargavi

Large language models (LLMs) have shown immense potential across various domains, but their high memory requirements and inference costs remain critical challenges for deployment. Post-training quantization (PTQ) has emerged as a promising…

Machine Learning · Computer Science 2026-01-05 Tianyi Zhang , Anshumali Shrivastava

Existing post-training quantization methods for large language models (LLMs) offer remarkable success. However, the increasingly marginal performance gains suggest that existing quantization strategies are insufficient to support the…

Machine Learning · Computer Science 2025-10-28 Jiaqi Zhao , Miao Zhang , Deng Xiang , Ming Li , Weili Guan , Liqiang Nie

Accurate prediction of enzymatic activity from amino acid sequences could drastically accelerate enzyme engineering for applications such as bioremediation and therapeutics development. In recent years, Protein Language Model (PLM)…

Quantitative Methods · Quantitative Biology 2025-05-07 Duncan F. Muir , Parker Grosjean , Margaux M. Pinney , Michael J. Keiser

The quantization of large language models (LLMs) has been a prominent research area aimed at enabling their lightweight deployment in practice. Existing research about LLM's quantization has mainly explored the interplay between weights and…

Computation and Language · Computer Science 2025-05-16 Yifei Gao , Jie Ou , Lei Wang , Jun Cheng , Mengchu Zhou
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