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The intensive care units (ICUs) are responsible for generating a wealth of useful data in the form of Electronic Health Record (EHR). This data allows for the development of a prediction tool with perfect knowledge backing. We aimed to…

Machine Learning · Computer Science 2020-07-28 Saumil Maheshwari , Rohit Verma , Anupam Shukla , Ritu Tiwari , Rishu Garg

Predicting the risk of mortality for patients with acute myocardial infarction (AMI) using electronic health records (EHRs) data can help identify risky patients who might need more tailored care. In our previous work, we built…

Machine Learning · Computer Science 2019-04-30 Seyedeh Neelufar Payrovnaziri , Laura A. Barrett , Daniel Bis , Jiang Bian , Zhe He

In clinical follow-up studies with a time-to-event end point, the difference in the restricted mean survival time (RMST) is a suitable substitute for the hazard ratio (HR). However, the RMST only measures the survival of patients over a…

Methodology · Statistics 2023-06-27 Zijing Yang , Chengfeng Zhang , Yawen Hou , Zheng Chen

In recent years, the growing availability of biomedical datasets featuring numerous longitudinal covariates has motivated the development of several multi-step methods for the dynamic prediction of survival outcomes. These methods employ…

Methodology · Statistics 2026-01-14 Mirko Signorelli , Sophie Retif

Researchers require timely access to real-world longitudinal electronic health records (EHR) to develop, test, validate, and implement machine learning solutions that improve the quality and efficiency of healthcare. In contrast, health…

Machine Learning · Computer Science 2020-12-21 Siddharth Biswal , Soumya Ghosh , Jon Duke , Bradley Malin , Walter Stewart , Jimeng Sun

Causal inference for observational longitudinal studies often requires the accurate estimation of treatment effects on time-to-event outcomes in the presence of time-dependent patient history and time-dependent covariates. To tackle this…

Machine Learning · Statistics 2022-06-17 Jie Zhu , Blanca Gallego

We propose a general formulation for continuous treatment recommendation problems in settings with clinical survival data, which we call the Deep Survival Dose Response Function (DeepSDRF). That is, we consider the problem of learning the…

Machine Learning · Statistics 2023-09-27 Jie Zhu , Blanca Gallego

Electroencephalography (EEG) during sleep is used by clinicians to evaluate various neurological disorders. In sleep medicine, it is relevant to detect macro-events (> 10s) such as sleep stages, and micro-events (<2s) such as spindles and…

Signal Processing · Electrical Eng. & Systems 2018-07-17 Stanislas Chambon , Valentin Thorey , Pierrick J. Arnal , Emmanuel Mignot , Alexandre Gramfort

Survival models can help medical practitioners to evaluate the prognostic importance of clinical variables to patient outcomes such as mortality or hospital readmission and subsequently design personalized treatment regimes. Electronic…

Machine Learning · Computer Science 2024-04-18 Yixuan Li , Archer Y. Yang , Ariane Marelli , Yue Li

Myocardial infarction (MI) is a leading cause of death, and its adverse outcomes are urgent to predict. Yet ECG-based prognostic models underperform because deep learning requires large, labelled datasets, which are scarce in medicine.…

Recently developed survival analysis methods improve upon existing approaches by predicting the probability of event occurrence in each of a number pre-specified (discrete) time intervals. By avoiding placing strong parametric assumptions…

Machine Learning · Statistics 2023-10-25 Jimmy Hickey , Ricardo Henao , Daniel Wojdyla , Michael Pencina , Matthew M. Engelhard

In intensive care units (ICUs), critically ill patients are monitored with electroencephalograms (EEGs) to prevent serious brain injury. The number of patients who can be monitored is constrained by the availability of trained physicians to…

Sepsis is a life threatening condition that requires timely detection in intensive care settings. Traditional machine learning approaches, including Naive Bayes, Support Vector Machine (SVM), Random Forest, and XGBoost, often rely on manual…

Machine Learning · Computer Science 2025-09-03 Hejiang Cai , Di Wu , Ji Xu , Xiang Liu , Yiziting Zhu , Xin Shu , Yujie Li , Bin Yi

Risk of suicide attempt varies over time. Understanding the importance of risk factors measured at a mental health visit can help clinicians evaluate future risk and provide appropriate care during the visit. In prediction settings where…

Analysis of longitudinal Electronic Health Record (EHR) data is an important goal for precision medicine. Difficulty in applying Machine Learning (ML) methods, either predictive or unsupervised, stems in part from the heterogeneity and…

Quantitative Methods · Quantitative Biology 2022-04-18 Alan D. Kaplan , Uttara Tipnis , Jean C. Beckham , Nathan A. Kimbrel , David W. Oslin , Benjamin H. McMahon

Increasingly, medical research is dependent on data collected for non-research purposes, such as electronic health records data (EHR). EHR data and other large databases can be prone to measurement error in key exposures, and unadjusted…

Methodology · Statistics 2020-05-13 Kyunghee Han , Thomas Lumley , Bryan E. Shepherd , Pamela A. Shaw

Effective learning from electronic health records (EHR) data for prediction of clinical outcomes is often challenging because of features recorded at irregular timesteps and loss to follow-up as well as competing events such as death or…

Machine Learning · Computer Science 2022-08-11 Intae Moon , Stefan Groha , Alexander Gusev

Accurate mortality prediction allows Intensive Care Units (ICUs) to adequately benchmark clinical practice and identify patients with unexpected outcomes. Traditionally, simple statistical models have been used to assess patient death risk,…

Machine Learning · Computer Science 2020-05-20 William Caicedo-Torres , Jairo Gutierrez

Early recognition of risky trajectories during an Intensive Care Unit (ICU) stay is one of the key steps towards improving patient survival. Learning trajectories from physiological signals continuously measured during an ICU stay requires…

Machine Learning · Computer Science 2019-12-24 Tiago Alves , Alberto Laender , Adriano Veloso , Nivio Ziviani

The large amount of time clinicians spend sifting through patient notes and documenting in electronic health records (EHRs) is a leading cause of clinician burnout. By proactively and dynamically retrieving relevant notes during the…

Information Retrieval · Computer Science 2023-08-17 Sharon Jiang , Shannon Shen , Monica Agrawal , Barbara Lam , Nicholas Kurtzman , Steven Horng , David Karger , David Sontag