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Focused ultrasound stimulated microbubbles have been shown to be capable of inducing blood flow shutdown and necrosis in a range of tissue types in an approach termed antivascular ultrasound or mechanical ablation. In oncology, this…

Medical Physics · Physics 2022-10-17 Xiaoxiao Zhao , Carly Pellow , David E. Goertz

Linking cavitation and anatomy was found to be important for predictable outcomes in Focused-Ultrasound Blood-Brain-Barrier-Opening and requires high resolution cavitation mapping. However, cavitation mapping techniques for planning and…

Drug delivery to the brain is limited by the blood-brain barrier (BBB). We developed a capacitive micromachined ultrasonic transducer (CMUT)-based transcranial focused ultrasound system capable of both delivering therapy via BBB opening and…

While the ultrasound and cavitation based therapies have mushroomed over the years, there is a lack of online monitoring the cavitation bubble dynamics in biological tissue. {\color{black}Here we demonstrate that with ultrasonic plane wave…

Fluid Dynamics · Physics 2023-05-26 S. Izak Ghasemian , F. Reuter , C. D. Ohl

In cases when it is desirable to transport medication through blood vessels, especially when dealing with brain cancer being confronted with the narrow arteries in the brain, the blood-brain barrier makes the medical treatment difficult.…

Fluid Dynamics · Physics 2023-03-27 Iver Brevik

Mechanisms for non-invasive target drug delivery using microbubbles and ultrasound have attracted growing interest. Microbubbles can be loaded with a therapeutic payload and tracked via ultrasound imaging to selectively release their…

Medical Physics · Physics 2019-02-07 S. Harput , L. Nie , D. M. J. Cowell , T. Carpenter , B. Raiton , J. McLaughlan , S. Freear

Ultrasound-matter interactions underpin numerous biomedical and soft-matter applications, yet simulating these phenomena is challenging due to the large separation of viscous and sonic time scales. Continuum methods capture large-scale wave…

Soft Condensed Matter · Physics 2026-02-18 Urban Čoko , Tilen Potisk , Matej Praprotnik

Ultrasound offers promising applications in biology and chemistry, but quantifying local ultrasound conditions remains challenging due to the lack of non-invasive measurement tools. We introduce antibubbles as novel optical reporters of…

Imaging the human brain vasculature with high spatial and temporal resolution remains challenging in the clinic today. Transcranial ultrasound is scarcely used for cerebrovascular imaging, due to low sensitivity and strong phase aberrations…

Microbubbles - used as contrast agents in ultrasound imaging - are important tools in biomedical research, having been used together with ultrasound to develop significant diagnostic and therapeutic techniques. It has been suggested that…

Medical Physics · Physics 2022-11-23 Prashant Pandey

Cavitation has historically been related to parameters measured at equilibrium, such as vapor pressure and surface tension. However, nucleation might occur when the liquid is metastable, especially for fast phenomena such as cavitation…

Fluid Dynamics · Physics 2025-04-16 Gianmaria Viciconte , Paolo Guida , Tadd T. Truscott , William L. Roberts

Identifying what aspects of brain activity are responsible for conscious perception remains one of the most challenging problems in science. While progress has been made through psychophysical studies employing EEG and fMRI, research would…

Neurons and Cognition · Quantitative Biology 2025-07-14 Daniel K. Freeman , Brian Odegaard , Seung-Schik Yoo , Matthias Michel

Low-intensity transcranial focused ultrasound (tFUS) is rapidly emerging as a transformative non-invasive brain stimulation (NIBS) modality characterized by high spatial resolution and ability to target deep brain circuits. Unlike…

Neurons and Cognition · Quantitative Biology 2026-04-02 William J. Tyler

Contact-free detection of human vital signs like heart rate and respiration rate will improve the patients' comfort and enables long-term monitoring of newborns or bedridden patients. For that, reliable and safe measurement techniques are…

Medical Physics · Physics 2020-07-28 Roman Kusche , Fabian John , Marco Cimdins , Horst Hellbrueck

The benefits of ultrasound are its ease-of-use and its ability to precisely deliver energy in opaque and complex media. However, most materials responsive to ultrasound show a weak response, requiring the use of high powers, which are…

Soft Condensed Matter · Physics 2023-08-01 Nicolas Moreno-Gomez , Athanasios G. Athanassiadis , Albert T. Poortinga , Peer Fischer

The clinical and economic burden of cardiovascular diseases (CVDs) poses a global challenge. Growing evidence suggests an early assessment of arterial stiffness can provide insights into the pathogenesis of CVDs. However, it remains…

Medical Physics · Physics 2020-12-07 Guo-Yang Li , Yuxuan Jiang , Yang Zheng , Weiqiang Xu , Zhaoyi Zhang , Yanping Cao

We analyse the ultrasound waves reflected by multiple bubbles in the linearized time-dependent acoustic model. The generated time-dependent wave field is estimated close to the bubbles. The motivation of this study comes from the therapy…

Analysis of PDEs · Mathematics 2024-09-24 Arpan Mukherjee , Mourad Sini

Regular blood pressure (BP) monitoring in clinical and ambulatory settings plays a crucial role in the prevention, diagnosis, treatment, and management of cardiovascular diseases. Recently, the widespread adoption of ambulatory BP…

Medical Physics · Physics 2023-12-19 Seyedeh Somayyeh Mousavi , Matthew A. Reyna , Gari D. Clifford , Reza Sameni

Continuous ambulatory monitoring of peripheral vascular perfusion could enable earlier detection of vascular dysfunction in individuals with diabetes mellitus and more timely management of cardiovascular disease. Clinical imaging modalities…

Ultrasonic cavitation is being used in medical applications as a way to influence matter, such as tissue or drug vehicles, on a micro-scale. Oscillating or collapsing cavitation bubbles provide transient mechanical force fields, which can,…

Medical Physics · Physics 2022-06-15 Emanuele Perra , Nick Hayward , Kenneth P. H. Pritzker , Heikki J. Nieminen
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