Spatially Selective Acoustic Pressure Reporting Using Antibubbles
Abstract
Ultrasound offers promising applications in biology and chemistry, but quantifying local ultrasound conditions remains challenging due to the lack of non-invasive measurement tools. We introduce antibubbles as novel optical reporters of local ultrasound pressure. These liquid-core, air-shell structures encapsulate fluorescent payloads, releasing them upon exposure to low-intensity ultrasound. We demonstrate their versatility by fabricating antibubbles with hydrophilic and hydrophobic payloads, revealing payload-dependent encapsulation efficiency and release dynamics. Using acoustic holograms, we showcase precise spatial control of payload release, enabling visualization of complex ultrasound fields. High-speed fluorescence imaging reveals a gentle, single-shot release mechanism occurring within 20-50 ultrasound cycles. It is thus possible to determine via an optical fluorescence marker what the applied ultrasound pressure was. This work thereby introduces a non-invasive method for mapping ultrasound fields in complex environments, potentially accelerating research in ultrasound-based therapies and processes. The long-term stability and versatility of these antibubble reporters suggest broad applicability in studying and optimizing ultrasound effects across various biological and chemical systems.
Keywords
Cite
@article{arxiv.2410.11477,
title = {Spatially Selective Acoustic Pressure Reporting Using Antibubbles},
author = {Nicolas Moreno Gomez and Athanasios G. Athanassiadis and Fabian Reuter and Hendrik Reese and Helen M. Jade and Albert Poortinga and Claus-Dieter Ohl and Peer Fischer},
journal= {arXiv preprint arXiv:2410.11477},
year = {2024}
}