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A numerical method using implicit surface representations is proposed to solve the linearized Poisson-Boltzmann equations that arise in mathematical models for the electrostatics of molecules in solvent. The proposed method used an implicit…

Numerical Analysis · Mathematics 2018-04-04 Yimin Zhong , Kui Ren , Richard Tsai

The numerical solution of differential equations can be formulated as an inference problem to which formal statistical approaches can be applied. However, nonlinear partial differential equations (PDEs) pose substantial challenges from an…

Numerical Analysis · Mathematics 2021-08-26 Junyang Wang , Jon Cockayne , Oksana Chkrebtii , T. J. Sullivan , Chris. J. Oates

The non-linear Poisson-Boltzmann equation for a circular, uniformly charged platelet, confined together with co- and counter-ions to a cylindrical cell, is solved semi-analytically by transforming it into an integral equation and solving…

Soft Condensed Matter · Physics 2009-10-31 R. J. F. Leote de Carvalho , E. Trizac , J. P Hansen

We consider the Poisson-Boltzmann equation in a periodic cell, representative of a porous medium. It is a model for the electrostatic distribution of $N$ chemical species diluted in a liquid at rest, occupying the pore space with charged…

Analysis of PDEs · Mathematics 2015-04-24 Gregoire Allaire , Jean-Francois Dufreche , Andro Mikelic , Andrey Piatnitski

The Poisson-Boltzmann equation offers an efficient way to study electrostatics in molecular settings. Its numerical solution with the boundary element method is widely used, as the complicated molecular surface is accurately represented by…

Numerical Analysis · Mathematics 2021-08-25 Stefan D. Search , Christopher D. Cooper , Elwin van't Wout

We develop an efficient and reliable adaptive finite element method (AFEM) for the nonlinear Poisson-Boltzmann equation (PBE). We first examine the regularization technique of Chen, Holst, and Xu; this technique made possible the first a…

Numerical Analysis · Mathematics 2010-10-01 Michael Holst , James Andrew McCammon , Zeyun Yu , Yongcheng Zhou , Yunrong Zhu

We prove the existence and uniqueness of weak solution of a Neumann boundary problem for an elliptic partial differential equation (PDE for short) with a singular divergence term which can only be understood in a weak sense. A probabilistic…

Probability · Mathematics 2018-04-24 Xue Yang , Jing Zhang

This work is concerned with the quantification of the epistemic uncertainties induced the discretization of partial differential equations. Following the paradigm of probabilistic numerics, we quantify this uncertainty probabilistically.…

Probability · Mathematics 2016-07-14 Ilias Bilionis

The Poisson-Boltzmann equation is a widely used model to study the electrostatics in molecular solvation. Its numerical solution using a boundary integral formulation requires a mesh on the molecular surface only, yielding accurate…

Numerical Analysis · Mathematics 2020-09-25 Vicente Ramm , Jehanzeb H. Chaudhry , Christopher D. Cooper

The generalized linear Boltzmann equation (GLBE) is a recently developed framework based on non-classical transport theory for modeling the expected value of particle flux in an arbitrary stochastic medium. Provided with a non-classical…

Computational Physics · Physics 2019-07-24 Ari Frankel

The behavior of electrolyte solutions close to a charged surface is studied theoretically. A modified Poisson-Boltzmann equation which takes into account the volume excluded by the ions in addition to the electrostatic interactions is…

Soft Condensed Matter · Physics 2007-05-23 I. Borukhov , D. Andelman , H. Orland

We present the theory and implementation of a Poisson-Boltzmann implicit solvation model for electrolyte solutions. This model can be combined with arbitrary electronic structure methods that provide an accurate charge density of the…

Computational Physics · Physics 2020-01-08 Christopher J. Stein , John M. Herbert , Martin Head-Gordon

In this paper, we apply the range-separated (RS) tensor format [6] for the construction of new regularization scheme for the Poisson-Boltzmann equation (PBE) describing the electrostatic potential in biomolecules. In our approach, we use…

Numerical Analysis · Mathematics 2024-12-20 Peter Benner , Venera Khoromskaia , Boris Khoromskij , Cleophas Kweyu , Matthias Stein

In computational biochemistry and biophysics, understanding the role of electrostatic interactions is crucial for elucidating the structure, dynamics, and function of biomolecules. The Poisson-Boltzmann (PB) equation is a foundational tool…

Biomolecules · Quantitative Biology 2024-10-08 Yongxian Wu , Qiang Zhu , Ray Luo

In this article we study adaptive finite element methods (AFEM) with inexact solvers for a class of semilinear elliptic interface problems. We are particularly interested in nonlinear problems with discontinuous diffusion coefficients, such…

Numerical Analysis · Mathematics 2016-08-24 Michael Holst , Ryan Szypowski , Yunrong Zhu

In this paper, we develop a domain decomposition method for the nonlinear Poisson-Boltzmann equation based on a solvent-excluded surface widely used in computational chemistry. The model relies on a nonlinear equation defined in…

Numerical Analysis · Mathematics 2024-04-08 Abhinav Jha , Benjamin Stamm

The aim of this article is to analyze numerical schemes using two-layer neural networks with infinite width for the resolution of the high-dimensional Poisson-Neumann partial differential equations (PDEs) with Neumann boundary conditions.…

Numerical Analysis · Mathematics 2023-07-14 Mathias Dus , Virginie Ehrlacher

The description of a conducting medium in thermal equilibrium, such as an electrolyte solution or a plasma, involves nonlinear electrostatics, a subject rarely discussed in the standard electricity and magnetism textbooks. We consider in…

Chemical Physics · Physics 2018-08-01 C. G. Gray , P. J. Stiles

We study the boundary layer solution to singular perturbation problems involving Poisson-Boltzmann (PB) type equations with a small parameter $\epsilon$ in general bounded smooth domains (including multiply connected domains) under the…

Analysis of PDEs · Mathematics 2025-06-27 Jhih-Hong Lyu , Tai-Chia Lin

Discretization of non-linear Poisson-Boltzmann Equation equations results in a system of non-linear equations with symmetric Jacobian. The Newton algorithm is the most useful tool for solving non-linear equations. It consists of solving a…

Mathematical Physics · Physics 2007-05-23 Sanjay Kumar Khattri