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Imaging through optical multimode fibers (MMFs) has the potential to enable hair-thin endoscopes that reduce the invasiveness of imaging deep inside tissues and organs. Current approaches predominantly require active wavefront shaping and…

Optics · Physics 2021-12-13 Szu-Yu Lee , Vicente J. Parot , Brett E. Bouma , Martin Villiger

Optical Diffraction Tomography (ODT) is a powerful non-invasive imaging technique widely used in biological and medical applications. While significant progress has been made in transmission configuration, reflection ODT remains challenging…

Optics · Physics 2026-05-14 Thomas Wasik , Victor Barolle , Alexandre Aubry , Josselin Garnier

The possibility to obtain a three-dimensional representation of a single object with sub-$\mu$m resolution is crucial in many fields, from material science to clinical diagnostics. This is typically achieved through tomography, which…

Label-Free Multiphoton Microscopy is a very powerful optical microscopy that can be applied to study samples with no need for exogenous fluorescent probes, keeping the main benefits of a Multiphoton approach, like longer penetration depths…

We report on the development of a compact (volume $\approx$ 100\:cm$^3$), multimode diffraction-limited Raman spectrograph and probe designed to be compact as possible. The spectrograph uses `off the shelf' optics, a custom 3D-printed…

Instrumentation and Detectors · Physics 2020-03-04 Christopher H. Betters , Joss Bland-Hawthorn , Salah Sukkarieh , Itandehui Gris-Sanchez , Sergio G. Leon-Saval

Spectral imaging enables the analysis of optical material properties that are invisible to the human eye. Different spectral capturing setups, e.g., based on filter-wheel, push-broom, line-scanning, or mosaic cameras, have been introduced…

Image and Video Processing · Electrical Eng. & Systems 2024-10-01 Eric L. Wisotzky , Jost Triller , Anna Hilsmann , Peter Eisert

Despite the tremendous progresses in wavefront control through or inside complex scattering media, several limitations prevent reaching practical feasibility for nonlinear imaging in biological tissues. While the optimization of nonlinear…

Optics · Physics 2016-12-06 Hilton B. de Aguiar , Sylvain Gigan , Sophie Brasselet

Aberrations limit scanning fluorescence microscopy when imaging in scattering materials such as biological tissue. Model-based approaches for adaptive optics take advantage of a computational model of the optical setup. Such models can be…

Optics · Physics 2021-07-07 Ivan Vishniakou , Johannes D. Seelig

Here we report a method for visualization of volumetric structural information of live biological samples with no exogenous contrast agents. The process is made possible through a technique that involves generation, synthesis and analysis…

Three-photon (3P) microscopy is getting traction due to its superior performance in deep tissues. Yet, aberrations and light scattering still pose one of the main limitations in the attainable depth ranges for high-resolution imaging. Here,…

Optical approaches to fluorescent, spectroscopic, and morphological imaging have made exceptional advances in the last decade. Super-resolution imaging and wide-field multiphoton imaging are now underpinning major advances across the…

Over the past decade, reflection matrix microscopy (RMM) and advanced image reconstruction algorithms have emerged to address the fundamental imaging depth limitations of optical microscopy in thick biological tissues and complex media. In…

Optics · Physics 2024-07-03 Sungsam Kang , Seokchan Yoon , Wonshik Choi

Non-invasive detection of objects embedded inside an optically scattering medium is essential for numerous applications in engineering and sciences. However, in most applications light at visible or near-infrared wavebands is scattered by…

This is the first article in a series of three dealing with the exploitation of speckle for imaging purposes. Speckle is the complex interference wave-field produced by a random distribution of un-resolved scatterers. In this paper, we show…

Applied Physics · Physics 2026-02-06 Elsa Giraudat , Flavien Bureau , William Lambert , Mathias Fink , Alexandre Aubry

Ultrathin lensless fibre endoscopes offer minimally invasive investigation, but they mostly operate as a rigid type due to the need for prior calibration of a fibre probe. Furthermore, most implementations work in fluorescence mode rather…

Optics · Physics 2020-10-23 Wonjun Choi , Munkyu Kang , Jin Hee Hong , Ori Katz , Youngwoon Choi , Wonshik Choi

In biological microscopy, light scattering represents the main limitation to image at depth. Recently, a set of wavefront shaping techniques has been developed in order to manipulate coherent light in strongly disordered materials. The…

Optics · Physics 2021-01-07 Antoine Boniface , Jonathan Dong , Sylvain Gigan

A flexible multimode fiber is an exceptionally efficient tool for in vivo deep tissue imaging. Recent advances in compressive multimode fiber sensing allow for imaging with sub-diffraction spatial resolution and sub-Nyquist speed. At…

Optics · Physics 2024-07-17 Zhouping Lyu , Shih-Te Hung , Carlas S. Smith , Lyubov V. Amitonova

Coherent X-ray diffraction microscopy is a method of imaging non-periodic isolated objects at resolutions only limited, in principle, by the largest scattering angles recorded. We demonstrate X-ray diffraction imaging with high resolution…

Optical imaging through complex scattering media is one of the major technical challenges with important applications in many research fields, ranging from biomedical imaging, astronomical telescopy, and spatially multiplex optical…

While the problem of estimating shapes and diffuse reflectances of human faces from images has been extensively studied, there is relatively less work done on recovering the specular albedo. This paper presents a lightweight solution for…

Computer Vision and Pattern Recognition · Computer Science 2019-11-28 Guoxian Song , Jianmin Zheng , Jianfei Cai , Tat-Jen Cham