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Fluorescence microscopy is a powerful tool for imaging biological samples with molecular specificity. In contrast, phase microscopy provides label-free measurement of the sample's refractive index (RI), which is an intrinsic optical…

Optics · Physics 2022-01-26 Yi Xue , David Ren , Laura Waller

This paper proposes a non-computational method of counteracting the effect of image degradation introduced by the diffraction phenomenon in lensless microscopy. All the optical images (whether focused by lenses or not) are diffraction…

Optics · Physics 2021-04-08 Sanjeev Kumar , Manjunatha Mahadevappa , Pranab Kumar Dutta

Reflective ptychography is a promising lensless imaging technique with a wide field of view, offering significant potential for applications in semiconductor manufacturing and detection. However, many semiconductor materials are coated with…

Optics · Physics 2025-01-03 Yun Gao , Qijun You , Peixiang Lu , Wei Cao

Multiple scattering of waves in disordered media is a nightmare whether it be for detection or imaging purposes. The best approach so far to get rid of multiple scattering is optical coherence tomography. It basically combines confocal…

Modern imaging systems can be enhanced in efficiency, compactness, and application through introduction of multilayer nanopatterned structures for manipulation of light based on its fundamental properties. High transmission efficiency…

Multiphoton microscopy (MPM) has gained enormous popularity over the years for its capacity to provide high resolution images from deep within scattering samples1. However, MPM is generally based on single-point laser-focus scanning, which…

Optics · Physics 2018-12-14 Devin R. Beaulieu , Ian G. Davison , Thomas G. Bifano , Jerome Mertz

Label-free imaging of rapidly moving, sub-diffraction sized structures has important applications in both biology and material science, as it removes the limitations associated with fluorescence tagging. However, unlabeled nanoscale…

Imaging through opaque, highly scattering walls is a long sought after capability with potential applications in a variety of fields. The use of wavefront shaping to compensate for scattering has brought a renewed interest as a potential…

A robust method and strategy for efficient full field-ofview and depth separation optical imaging through scattering media regardless of the three-dimensional (3D) optical memory effect are proposed. In this method, the problem of imaging…

Optics · Physics 2020-01-17 Wei Li , Jietao Liu , Shunfu He , Lixian Liu , Xiaopeng Shao

We present a physically intuitive matrix approach for wave imaging and characterization in scattering media. The experimental proof-of-concept is performed with ultrasonic waves, but this approach can be applied to any field of wave physics…

Applied Physics · Physics 2020-07-01 William Lambert , Laura A. Cobus , Mathieu Couade , Mathias Fink , Alexandre Aubry

Holotomography (HT) has revolutionized quantitative label-free 3D imaging, yet conventional lens-based implementations are fundamentally constrained in field-of-view (FOV) and imaging depth, limiting their utility for critical…

Using conventional refraction-based optical lens, it is challenging to achieve both high-resolution imaging and long-working-distance condition. To increase the numerical aperture of a lens, the working distance should be compensated, and…

Optics · Physics 2018-09-12 YoonSeok Baek , KyeoReh Lee , YongKeun Park

Spectral imaging is a fundamental diagnostic technique with widespread application. Conventional spectral imaging approaches have intrinsic limitations on spatial and spectral resolutions due to the physical components they rely on. To…

Image and Video Processing · Electrical Eng. & Systems 2021-06-07 Figen S. Oktem , Oğuzhan Fatih Kar , Can Deniz Bezek , Farzad Kamalabadi

Multiple scattering of waves presents challenges for imaging complex media but offers potential for their characterization. Its onset is actually governed by the scattering mean free path $\ell_s$ that provides crucial information on the…

Imaging with optical resolution through and inside complex samples is a difficult challenge with important applications in many fields. The fundamental problem is that inhomogeneous samples, such as biological tissues, randomly scatter and…

Optics · Physics 2014-10-17 Ori Katz , Pierre Heidmann , Mathias Fink , Sylvain Gigan

We study active array imaging of small but strong scatterers in homogeneous media when multiple scattering between them is important. We use the Foldy-Lax equations to model wave propagation with multiple scattering when the scatterers are…

Mathematical Physics · Physics 2015-12-15 Anwei Chai , Miguel Moscoso , George Papanicolaou

Light-field microscopy represents a promising solution for microscopic volumetric imaging, thanks to its capability to encode information on multiple planes in a single acquisition. This is achieved through its peculiar simultaneous capture…

Reflecting light to a pre-determined non-specular direction is an important ability of metasurfaces, which is the basis for a wide range of applications (e.g., beam steering/splitting and imaging). However, anomalous reflection with 100%…

Optics · Physics 2021-11-16 Tao He , Tong Liu , Shiyi Xiao , Zeyong Wei , Zhanshan Wang , Lei Zhou , Xinbin Cheng

Label-free nonlinear optical microscopy has become a powerful tool for biomedical research. However, the possible photodamage risk hinder further clinical applications. To reduce these adverse effects, we constructed a new platform of…

Optics · Physics 2022-10-26 Geng Wang , Stephen A. Boppart , Haohua Tu

Optical endoscopy plays a crucial role in minimally invasive medical diagnostics and therapeutic procedures. Nonetheless, state-of-the-art endoscopic zoom objectives are bulky, requiring multi-element lens actuation, which can limit…