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The brain-age gap is one of the most investigated risk markers for brain changes across disorders. While the field is progressing towards large-scale models, recently incorporating uncertainty estimates, no model to date provides the…

This study contributes to the ongoing exploration of methods to enhance the environmental design, cognitive function, and overall wellbeing, primarily focusing on understanding the modulation of human cognitive performance by artificial…

Human-Computer Interaction · Computer Science 2024-06-06 Armin Mostafavi , Milica Vujovic , Tong Bill Xu , Michael Hensel

The aging society urgently requires scalable methods to monitor cognitive decline and identify social and psychological factors indicative of dementia risk in older adults. Our machine learning (ML) models captured facial, acoustic,…

Functional connectivity (FC) analysis of resting-state fMRI data provides a framework for characterizing brain networks and their association with participant-level covariates. Due to the high dimensionality of neuroimaging data, standard…

Methodology · Statistics 2025-08-18 Wei Zhao , Brian J. Reich , Emily C. Hector

Spontaneous fluctuations of the BOLD (Blood Oxygen Level-Dependent) signal, measured with fMRI (functional Magnetic Resonance Imaging), display a rich and neurobiologically relevant functional connectivity structure. This structure is…

Neurons and Cognition · Quantitative Biology 2012-09-24 Enzo Tagliazucchi , Frederic von Wegner , Astrid Morzelewski , Verena Brodbeck , Helmut Laufs

This study investigates fall risk prediction in older adults using various machine learning models trained on accelerometric, non-accelerometric, and combined data from 146 participants. Models combining both data types achieved superior…

The human electroencephalogram (EEG) of sleep undergoes profound changes with age. These changes can be conceptualized as "brain age", which can be compared to an age norm to reflect the deviation from normal aging process. Here, we develop…

Depression has been the leading cause of mental-health illness worldwide. Major depressive disorder (MDD), is a common mental health disorder that affects both psychologically as well as physically which could lead to loss of lives. Due to…

Computer Vision and Pattern Recognition · Computer Science 2019-09-05 Anupama Ray , Siddharth Kumar , Rutvik Reddy , Prerana Mukherjee , Ritu Garg

Medical vision-language models (Med-VLMs) have shown impressive results in tasks such as report generation and visual question answering, but they still face several limitations. Most notably, they underutilize patient metadata and lack…

Computer Vision and Pattern Recognition · Computer Science 2025-10-16 Fangqi Cheng , Surajit Ray , Xiaochen Yang

To address the trade-off between robustness and performance for robust VLM, we observe that function words could incur vulnerability of VLMs against cross-modal adversarial attacks, and propose Function-word De-Attention (FDA) accordingly…

Machine Learning · Computer Science 2026-04-17 Qiwei Tian , Chenhao Lin , Zhengyu Zhao , Chao Shen

Neuroimaging-based prediction methods for intelligence and cognitive abilities have seen a rapid development in literature. Among different neuroimaging modalities, prediction based on functional connectivity (FC) has shown great promise.…

Neurons and Cognition · Quantitative Biology 2023-07-20 Yang Li , Xin Ma , Raj Sunderraman , Shihao Ji , Suprateek Kundu

Cognitive load assessment is crucial for understanding human performance in various domains. This study investigates the impact of different task conditions and time constraints on cognitive load using multiple measures, including…

Human-Computer Interaction · Computer Science 2023-12-19 Arash Abbasi Larki , Akram Shojaei , Mehdi Delrobaei

Alzheimer's disease (AD), as a progressive brain disease, affects cognition, memory, and behavior. Similarly, limbic-predominant age-related TDP-43 encephalopathy (LATE) is a recently defined common neurodegenerative disease that mimics the…

Computers and Society · Computer Science 2022-09-13 Xinxing Wu , Chong Peng , Peter T. Nelson , Qiang Cheng

The study's objective is to explore the distinctions in the functional brain network connectivity between Alzheimer's Disease (AD) patients and normal controls using Functional Magnetic Resonance Imaging (fMRI). The study included 590…

Neurons and Cognition · Quantitative Biology 2023-05-17 Yongcheng Yao

Early detection of cognitive impairment is critical for timely diagnosis and intervention, yet infrequent clinical assessments often lack the sensitivity and temporal resolution to capture subtle cognitive declines in older adults. Passive…

The emergence of an ageing population is a significant public health concern. This has led to an increase in the number of people living with progressive neurodegenerative disorders like dementia. Consequently, the strain this is places on…

Computers and Society · Computer Science 2019-03-29 C. Chalmers , P. Fergus , C. Aday Curbelo Montanez , S. Sikdar , F. Ball , B. Kendall

Background: Symptom rating scales in psychiatry are limited by reliance on self-report, and lack of predictive power. Actigraphy, a passive wearable-based method for measuring sleep and physical activity, offers objective, high-resolution…

Quantitative Methods · Quantitative Biology 2025-07-31 Dylan Hamitouche , Tihare Zamorano , Youcef Barkat , Deven Parekh , Lena Palaniyappan , David Benrimoh

Objective: To investigate whether performance (number of correct decisions) of humans supported by a computer alerting tool can be improved by tailoring the tool's alerting threshold (sensitivity/specificity combination) according to user…

Human-Computer Interaction · Computer Science 2021-06-28 Marwa Gadala , Lorenzo Strigini , Peter Ayton

Mental fatigue increases the risk of operator error in language comprehension tasks. In order to prevent operator performance degradation, we used EEG signals to assess the mental fatigue of operators in human-computer systems. This study…

Artificial Intelligence · Computer Science 2021-04-20 Chunhua Ye , Zhong Yin , Chenxi Wu , Xiayidai Abulaiti , Yixing Zhang , Zhenqi Sun , Jianhua Zhang

We explore the application of large language models (LLMs), pre-trained models with massive textual data for detecting and improving these altered states. We investigate the use of LLMs to estimate attention states, sleep stages, and sleep…

Signal Processing · Electrical Eng. & Systems 2024-08-16 Akane Sano , Judith Amores , Mary Czerwinski