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Droplets form a cornerstone of the spatiotemporal organization of biomolecules in cells. These droplets are controlled using physical processes like chemical reactions and imposed gradients, which are costly to simulate using traditional…
A coarse-grained model developed by Marrink et al. [J. Phys. Chem. B 111, 7812 (2007)] is applied to investigate vesiculation of lipid [dipalmitoylphosphatidylcholine (DPPC)] droplets in water. Three kinds of morphologies of micelles are…
Polydimethylsiloxane (PDMS) microfluidic devices have become a standard tool for engineering cells and multicellular networks in vitro. However, the reservoirs, or through-holes where cells access the devices, are usually fabricated…
Microcapsules are commonly used in applications ranging from therapeutics to personal care products due to their ability to deliver encapsulated species through their porous shells. Here, we demonstrate a simple and scalable approach to…
The compartmentalization of chemical reactions within droplets has advantages in low costs, reduced consumption of reagents and increased throughput. Reactions in small droplets have also been shown to greatly accelerate the rate of many…
Hyaluronic acid is an abundant polyelectrolyte in the human body that forms extracellular hydrogels in connective tissues. It is essential for regulating tissue biomechanics and cell-cell communication, yet hyaluronan overexpression is…
We experimentally investigate the dissolution of microscale sessile alcohol droplets in water under the influence of impermeable vertical confinement. The introduction of confinement suppresses the mass transport from the droplet to bulk…
Microfluidic valves play a key role within microfluidic systems by regulating fluid flow through distinct microchannels, enabling many advanced applications in medical diagnostics, lab-on-chips, and laboratory automation. While microfluidic…
Guided by extensive numerical simulations, we propose a microfluidic device that can sort elastic capsules by their deformability. The device consists of a duct embedded with a semi-cylindrical obstacle, and a diffuser which further…
Biological cells utilize membranes and liquid-like droplets, known as biomolecular condensates, to structure their interior. The interaction of droplets and membranes, despite being involved in several key biological processes, is so far…
Droplet-based microfluidics turned out to be an efficient and adjustable platform for digital analysis, encapsulation of cells, drug formulation, and polymerase chain reaction. Typically, for most biomedical applications, the handling of…
Soft colloids are increasingly used as model systems to address fundamental issues such as crystallisation and the glass and jamming transitions. Among the available classes of soft colloids, microgels are emerging as the gold standard.…
Cell spheroids are in vitro multicellular model systems that mimic the crowded micro-environment of biological tissues. Their mechanical characterization can provide valuable insights in how single-cell mechanics and cell-cell interactions…
Droplets, sub-millilitre liquid volumes with at least one interface, have traditionally served as compartments for storing, transporting, and delivering materials. Beyond familiar applications in food, coatings, and consumer goods, they…
We report on the development of a new model of alveolar air-tissue interface on a chip. The model consists of an array of suspended hexagonal monolayers of gelatin nanofibers supported by microframes and a microfluidic device for the patch…
Liquid droplet dynamics are widely used in biological and engineering applications, which contain complex interfacial instabilities and pattern formation such as droplet merging, splitting, and transport. This paper studies a class of mean…
A novel micromixing technique that exploit a thrust of droplets into the mixing interface is developed. The technique enhances the mixing by injecting immiscible droplets in a mixing channel and the methodology enables a control of the…
To evaluate the role of common substrates in the transmission of respiratory viruses, uniformly distributed microdroplets of artificial saliva were generated using an advanced inkjet printing technology to replicate the aerosol droplets,…
Preparation of nanoemulsions of triglyceride oils in water usually requires high mechanical energy and sophisticated equipment. Recently, we showed that alpha-to-beta (viz. gel-to-crystal) phase transition, observed with most lipid…
Macrocellular silicone polymers are obtained after solidification of the continuous phase of a PDMS (polydimethylsiloxane) emulsion, which contains PEG (polyethylene glycol) drops of sub-millimetric dimensions. Coalescence of the liquid…