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Significant progress has been made to increase access to droplet microfluidics for labs with limited microfluidics expertise or fabrication equipment. In particular, using off-the-shelf systems has been a valuable approach. However, the…

This review focuses on a microparticle-producing technique widely used for its efficacy in controlling physicochemical properties: droplet-based microfluidics. The review describes the various strategies applied under this technique, and…

Materials Science · Physics 2020-09-16 Cheng Zhang , Romain Grossier , Nadine Candoni , Stéphane Veesler

In this study, we present a two-stage method for fabricating monodisperse alginate hydrogel microspheres using a symmetrically designed flow-focusing microfluidic device. One of the flow-focusing junctions generates alginate hydrogel…

Chemical Physics · Physics 2024-12-04 Qing Qin , Yu Zhang , Yubei Wei , Jinnuo , Lv , Meiling Tian , Yuanyuan Sun , Xingjian , Huang , Jianglin Li , Yifeng , Su , Xiaoliang Xiang , Xing Hu , Zhizhi Zhou

The indiscriminate use of antibiotics and the emergence of resistant microorganisms have become a major challenge for the food industry. The purpose of this work was to microencapsulate the bacteriophage UFV-AREG1 in a calcium alginate…

The precise encapsulation of deformable particles in multiphase flows involves complex transient Fluid-Structure Interactions (FSI) and topological interfacial changes. In the context of single-cell analysis, a numerical framework that…

Fluid Dynamics · Physics 2026-03-18 Andi Liu , Guohui Hu

Scalable technologies for the production of bio-compatible complex microfibers with controllable size and composition at competitively high throughput are urgently needed in order to meet the growing demand for such microstructures in…

Applied Physics · Physics 2022-08-11 Marangon Francesco , Baumgartner David , Planchette Carole

This study investigates the hydrodynamics of droplet formation in a T-shaped cylindrical microfluidic device using micro-PIV experiments and CFD simulations. Devices of 150 micro-m internal diameter were fabricated from PDMS via a…

Fluid Dynamics · Physics 2026-03-04 Pratibha Dogra , Ram Prakash Bharti , Gaurav Sharma

Many biological, culinary, and engineering processes lead to the co-encapsulation of several soft particles within a liquid interface. In these situations the particles are bound together by the capillary forces that deform them and…

Soft Condensed Matter · Physics 2026-01-01 Shunsuke Saita , Finn Bastian Molzahn , Clara Delahousse , Julien Husson , Charles N. Baroud

Curable hydrogels have tunable properties that make them well-suited for applications in drug delivery, cell therapies, and 3D bioprinting. Advances in microfluidic droplet generation enable rapid fabrication of polymer-filled droplets.…

Fluid Dynamics · Physics 2025-12-02 Sabrina Marnoto , Avi J. Patel , Sara M. Hashmi

We present a new system based on alginate gels for the encapsulation of a ferrofluid drop, which allows us to create millimeter-sized elastic capsules that are highly deformable by inhomogeneous magnetic fields. We use a combination of…

Soft Condensed Matter · Physics 2019-02-26 Christian Wischnewski , Elena Zwar , Heinz Rehage , Jan Kierfeld

The production of monodisperse particles or droplets is a longstanding issue across various fields, from aerosol science to inkjet printing. In bioengineering, submillimeter cell laden hydrogel capsules have proven valuable for developing…

Fluid Dynamics · Physics 2025-03-28 Lucas Suire , Anirban Jana , Pierre Nassoy , Amaury Badon

The occurrence of concentration and temperature gradients in saline microdroplets evaporating directly in air makes them unsuitable for nucleation studies where homogeneous composition is required. This can be addressed by immersing the…

Materials Science · Physics 2021-11-24 Ruel Cedeno , Romain Grossier , Nadine Candoni , Adrian Flood , Stéphane Veesler

Biocompatible microencapsulation is of widespread interest for the targeted delivery of active species in fields such as pharmaceuticals, cosmetics and agro-chemistry. Capsules obtained by the self-assembly of polymers at interfaces enable…

We have developed a method to produce aqueous microdroplets in an oil phase, based on the periodic extraction of a pending droplet across the oil/air interface. This interface forms a capillary trap inside which a droplet can be captured…

Soft Condensed Matter · Physics 2018-01-17 M. Valet , L. -L. Pontani , A. M. Prevost , E. Wandersman

Solutions of macromolecules can undergo liquid-liquid phase separation to form droplets with ultra-low surface tension. Droplets with such low surface tension wet and spread over common surfaces such as test tubes and microscope slides,…

Encapsulation of chemicals using polymer membranes enables to control their transport and delivery for applications such as agrochemistry or detergency. To rationalize the design of polymer capsules, it is necessary to understand how the…

Soft Condensed Matter · Physics 2018-12-18 Corentin Tregouët , Thomas Salez , Mathilde Reyssat , Cécile Monteux

In this paper we present a comprehensive study of the step-emulsification process for high-throughput production of (sub-)$\mu$m-size monodisperse droplets. The microfluidic device combines a Hele-Shaw nanofluidic cell with a step-like…

Fluid Dynamics · Physics 2014-05-15 Z. Li , A. M. Leshansky , L. M. Pismen , P. Tabeling

Droplet-based microfluidics systems have become widely used in recent years thanks to their advantages, varying from the possibility of handling small fluid volumes to directly synthesizing and encapsulating various living forms for…

Ultrasound-vaporizable microdroplets can be exploited for targeted drug delivery. However, it requires customized microfluidic techniques able to produce monodisperse, capillary-sized and biocompatible multiple emulsions. Recent development…

Soft Condensed Matter · Physics 2019-12-17 E. Teston , V. Hingot , V. Faugeras , C. Errico , M. Bezagu , M. Tanter , O. Couture

We have developed a coupled level set and volume of fluid-based computational fluid dynamics model to analyze the droplet formation mechanism in a square flow-focusing microchannel. We demonstrate a flexible manipulation of droplet…

Fluid Dynamics · Physics 2025-10-09 Somasekhara Goud Sontti , Arnab Atta
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