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The problem of the onset and growth of solid tumour in homogeneous tissue is regarded using an approach based on local interaction between the tumoral and the sane tissue cells. The characteristic sizes and growth rates of spherical…

Cell Behavior · Quantitative Biology 2007-05-23 R. G. Khlebopros , V. A. Slepkov , V. G. Sukhovolsky , Y. V. Mironov , V. E. Fedorov , S. P. Gabuda

In this paper, we study a phase field model for a tumor growth model of Cahn--Hilliard type in which the often assumed parabolic relaxation of the chemical potential is replaced by a hyperbolic one. We show that the resulting…

Analysis of PDEs · Mathematics 2026-02-16 Pierluigi Colli , Elisabetta Rocca , Jürgen Sprekels

In this work we present a flexible tool for tumor progression, which simulates the evolutionary dynamics of cancer. Tumor progression implements a multi-type branching process where the key parameters are the fitness landscape, the mutation…

Populations and Evolution · Quantitative Biology 2013-03-22 Johannes G. Reiter , Ivana Bozic , Krishnendu Chatterjee , Martin A. Nowak

In this paper we present a study of local dynamics of the growth of cancer tumor and healthy cells considering the presence of nutrients in the system. We also analyze the evolution of system if we take indirectly into account the level of…

Biological Physics · Physics 2019-01-29 Cristian C. Pérez Águila , Maura Cárdenas G. , J. Fernando Rojas

We consider a diffuse interface model of tumor growth proposed by A.~Hawkins-Daruud et al. This model consists of the Cahn-Hilliard equation for the tumor cell fraction $\varphi$ nonlinearly coupled with a reaction-diffusion equation for…

Analysis of PDEs · Mathematics 2014-12-05 Sergio Frigeri , Maurizio Grasselli , Elisabetta Rocca

We study a stochastic phase-field model for tumor growth dynamics coupling a stochastic Cahn-Hilliard equation for the tumor phase parameter with a stochastic reaction-diffusion equation governing the nutrient proportion. We prove strong…

Analysis of PDEs · Mathematics 2021-01-19 Carlo Orrieri , Elisabetta Rocca , Luca Scarpa

We study a tumor growth model in two space dimensions, where proliferation of the tumor cells leads to expansion of the tumor domain and migration of surrounding normal tissues into the exterior vacuum. The model features two moving…

Analysis of PDEs · Mathematics 2020-02-11 Inwon Kim , Jiajun Tong

In this paper, we study an initial boundary value problem of the Cahn-Hilliard-Darcy system with a non-autonomous mass source term $S$ that models tumor growth. We first prove the existence of global weak solutions as well as the existence…

Analysis of PDEs · Mathematics 2023-07-28 Jie Jiang , Hao Wu , Songmu Zheng

This article deals with the variable coefficient thin obstacle problem in $n+1$ dimensions. We address the regular free boundary regularity, the behavior of the solution close to the free boundary and the optimal regularity of the solution…

Analysis of PDEs · Mathematics 2016-03-23 Herbert Koch , Angkana Rüland , Wenhui Shi

We consider a free boundary tumor model under the presence of angiogenesis and time delays in the process of proliferation, in which the cell location is incorporated. It is assumed that the tumor attracts blood vessels at a rate…

Analysis of PDEs · Mathematics 2021-03-09 Zejia Wang , Haihua Zhou , Huijuan Song

In the present article the diffusion equation is used to model the spatio-temporal dynamics of a tumor, taking into account the heterogeneous of the medium. This approach makes it possible to take into account the complex geometric shape of…

Biological Physics · Physics 2023-02-07 Maxim V. Polyakov , Valeria V. Ten

In this paper, we study a phase-space analysis of a mathematical model of tumor growth with an immune response. Mathematical analysis of the model equations with multipoint initial condition, regarding to dissipativity, boundedness of…

Tissues and Organs · Quantitative Biology 2018-01-17 Veli Shakhmurov

Collective migration dominates many phenomena, from cell movement in living systems to abiotic self-propelling particles. Focusing on the early stages of tumor evolution, we enunciate the principles involved in cell dynamics and highlight…

Cell Behavior · Quantitative Biology 2018-05-02 Abdul N Malmi-Kakkada , Xin Li , Himadri S. Samanta , Sumit Sinha , D. Thirumalai

We investigate the dynamics of a nonlinear model for tumor growth within a cellular medium. In this setting the "tumor" is viewed as a multiphase flow consisting of cancerous cells in either proliferating phase or quiescent phase and a…

Analysis of PDEs · Mathematics 2015-03-31 Donatella Donatelli , Konstantina Trivisa

We present a robust computational framework for Hele-Shaw tumor growth with necrotic cores, a problem identified as the incompressible limit of the Porous Media Equation. Simulating this system presents a fundamental challenge: while the…

Numerical Analysis · Mathematics 2026-02-16 Yu Feng , Shuo Ling , Wenjun Ying , Zhennan Zhou

In this paper, we studied phase-space analysis of a certain mathematical model of tumor growth with an immune responses and chemotherapy therapy. Mathematical modelling of this process is viewed as a potentially powerful tool in the…

Dynamical Systems · Mathematics 2018-03-15 Veli Shakhmurov , Akif Maharramov , Bunyad Shahmurzada

A mathematical model for tissue growth is considered. This model describes the dynamics of the density of cells due to pressure forces and proliferation. It is known that such cell population model converges at the incompressible limit…

Analysis of PDEs · Mathematics 2017-03-01 Sophie Hecht , Nicolas Vauchelet

In this survey article, a variety of systems modeling tumor growth are discussed. In accordance with the hallmarks of cancer, the described models incorporate the primary characteristics of cancer evolution. Specifically, we focus on…

Dynamical Systems · Mathematics 2023-03-21 Marvin Fritz

This paper studies the following system of differential equations modeling tumor angiogenesis in a bounded smooth domain $\Omega \subset \mathbb{R}^N$ ($N=1,2$): $$\label{0} \left\{\begin{array}{ll} p_t=\Delta p-\nabla\cdotp…

Analysis of PDEs · Mathematics 2019-03-27 Peter Y. H. Pang , Yifu Wang

In this work, we consider a diffuse interface model for tumour growth in the presence of a nutrient which is consumed by the tumour. The system of equations consists of a Cahn--Hilliard equation with source terms for the tumour cells and a…

Numerical Analysis · Mathematics 2022-05-09 Harald Garcke , Dennis Trautwein
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