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In multicenter biomedical research, integrating data from multiple decentralized sites provides more robust and generalizable findings due to its larger sample size and the ability to account for the between-site heterogeneity. However,…

Methodology · Statistics 2025-12-29 Xiaokang Liu , Yuchen Yang , Yifei Sun , Jiang Bian , Yanyuan Ma , Raymond J. Carroll , Yong Chen

Clinical evidence encompasses the associations and impacts between patients, interventions (such as drugs or physiotherapy), problems, and outcomes. The goal of recommending clinical evidence is to provide medical practitioners with…

Computation and Language · Computer Science 2023-04-05 Maolin Luo , Xiang Zhang

Deep learning in medical imaging is often limited by scarce and imbalanced annotated data. We present SSGNet, a unified framework that combines class specific generative modeling with iterative semisupervised pseudo labeling to enhance both…

Computer Vision and Pattern Recognition · Computer Science 2025-10-08 Mosong Ma , Tania Stathaki , Michalis Lazarou

Synthetic healthcare data generation offers a promising solution to research limitations in clinical settings caused by privacy and regulatory constraints. However, current synthetic data generation approaches require specialized knowledge…

Machine Learning · Computer Science 2026-02-19 Nitish Nagesh , Salar Shakibhamedan , Mahdi Bagheri , Ziyu Wang , Nima TaheriNejad , Axel Jantsch , Amir M. Rahmani

When deep learning models are sequentially trained on new data, they tend to abruptly lose performance on previously learned tasks, a critical failure known as catastrophic forgetting. This challenge severely limits the deployment of AI in…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Paraskevi-Antonia Theofilou , Anuhya Thota , Stefanos Kollias , Mamatha Thota

Many practical medical imaging scenarios include categories that are under-represented but still crucial. The relevance of image recognition models to real-world applications lies in their ability to generalize to these rare classes as well…

Computer Vision and Pattern Recognition · Computer Science 2025-05-22 Daniya Najiha A. Kareem , Jean Lahoud , Mustansar Fiaz , Amandeep Kumar , Hisham Cholakkal

Annotation scarcity has become a major obstacle for training powerful deep-learning models for medical image segmentation, restricting their deployment in clinical scenarios. To address it, semi-supervised learning by exploiting abundant…

Computer Vision and Pattern Recognition · Computer Science 2023-11-21 Qingjie Zeng , Yutong Xie , Zilin Lu , Mengkang Lu , Yicheng Wu , Yong Xia

Clinical diagnosis is a highly specialized discipline requiring both domain expertise and strict adherence to rigorous guidelines. While current AI-driven medical research predominantly focuses on knowledge graphs or natural text…

Machine Learning · Computer Science 2025-12-12 Haolin Li , Tianjie Dai , Zhe Chen , Siyuan Du , Jiangchao Yao , Ya Zhang , Yanfeng Wang

A major obstacle to achieving global convergence in distributed and federated learning is the misalignment of gradients across clients, or mini-batches due to heterogeneity and stochasticity of the distributed data. In this work, we show…

Machine Learning · Computer Science 2021-12-14 Yatin Dandi , Luis Barba , Martin Jaggi

Although response-adaptive randomisation (RAR) has gained substantial attention in the literature, it still has limited use in clinical trials. Amongst other reasons, the implementation of RAR in real world trials raises important practical…

Applications · Statistics 2025-09-16 Rajenki Das , Nina Deliu , Mark Toshner , Sofía S Villar

Rich and accurate medical image segmentation is poised to underpin the next generation of AI-defined clinical practice by delineating critical anatomy for pre-operative planning, guiding real-time intra-operative navigation, and supporting…

Computer Vision and Pattern Recognition · Computer Science 2026-05-22 Junwen Wang , Oscar MacCormac , William Rochford , Aaron Kujawa , Jonathan Shapey , Tom Vercauteren

Long-tailed problems in healthcare emerge from data imbalance due to variability in the prevalence and representation of different medical conditions, warranting the requirement of precise and dependable classification methods. Traditional…

Computer Vision and Pattern Recognition · Computer Science 2024-10-08 Pankhi Kashyap , Pavni Tandon , Sunny Gupta , Abhishek Tiwari , Ritwik Kulkarni , Kshitij Sharad Jadhav

Automated data augmentation, which aims at engineering augmentation policy automatically, recently draw a growing research interest. Many previous auto-augmentation methods utilized a Density Matching strategy by evaluating policies in…

Computer Vision and Pattern Recognition · Computer Science 2022-07-22 Jianwei Zhang , Dong Li , Lituan Wang , Lei Zhang

High model performance, on average, can hide that models may systematically underperform on subgroups of the data. We consider the tabular setting, which surfaces the unique issue of outcome heterogeneity - this is prevalent in areas such…

Machine Learning · Computer Science 2022-10-25 Nabeel Seedat , Jonathan Crabbé , Ioana Bica , Mihaela van der Schaar

Numerous practical medical problems often involve data that possess a combination of both sparse and non-sparse structures. Traditional penalized regularizations techniques, primarily designed for promoting sparsity, are inadequate to…

Methodology · Statistics 2023-11-10 Shun Yu , Yuehan Yang

Semi-supervised learning for medical image segmentation presents a unique challenge of efficiently using limited labeled data while leveraging abundant unlabeled data. Despite advancements, existing methods often do not fully exploit the…

Computer Vision and Pattern Recognition · Computer Science 2024-12-12 Bin Zhao , Chunshi Wang , Shuxue Ding

Clinical decision-making relies on the integration of information across various data modalities, such as clinical time-series, medical images and textual reports. Compared to other domains, real-world medical data is heterogeneous in…

Image and Video Processing · Electrical Eng. & Systems 2025-08-14 Baraa Al Jorf , Farah Shamout

Recent works leveraging Graph Neural Networks to approach graph matching tasks have shown promising results. Recent progress in learning discrete distributions poses new opportunities for learning graph matching models. In this work, we…

Machine Learning · Computer Science 2021-09-14 Linfeng Liu , Michael C. Hughes , Soha Hassoun , Li-Ping Liu

Causal inference is essential for developing and evaluating medical interventions, yet real-world medical datasets are often difficult to access due to regulatory barriers. This makes synthetic data a potentially valuable asset that enables…

Machine Learning · Computer Science 2025-10-22 Harry Amad , Zhaozhi Qian , Dennis Frauen , Julianna Piskorz , Stefan Feuerriegel , Mihaela van der Schaar

Long-context models are essential for many applications but face inefficiencies in loading large KV caches during decoding. Prior methods enforce fixed token budgets for sparse attention, assuming a set number of tokens can approximate full…

Machine Learning · Computer Science 2025-02-19 Kan Zhu , Tian Tang , Qinyu Xu , Yile Gu , Zhichen Zeng , Rohan Kadekodi , Liangyu Zhao , Ang Li , Arvind Krishnamurthy , Baris Kasikci