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Background. Eosinophilic esophagitis (EoE) is an allergic inflammatory condition of the esophagus associated with elevated numbers of eosinophils. Disease diagnosis and monitoring requires determining the concentration of eosinophils in…

Eosinophilic Esophagitis (EoE) is a chronic, immune/antigen-mediated esophageal disease, characterized by symptoms related to esophageal dysfunction and histological evidence of eosinophil-dominant inflammation. Owing to the intricate…

Image and Video Processing · Electrical Eng. & Systems 2023-08-15 Juming Xiong , Yilin Liu , Ruining Deng , Regina N Tyree , Hernan Correa , Girish Hiremath , Yaohong Wang , Yuankai Huo

Eosinophilic Esophagitis (EoE) is an inflammatory esophageal disease which is increasing in prevalence. The diagnostic gold-standard involves manual review of a patient's biopsy tissue sample by a clinical pathologist for the presence of 15…

Image and Video Processing · Electrical Eng. & Systems 2021-01-15 William Adorno , Alexis Catalano , Lubaina Ehsan , Hans Vitzhum von Eckstaedt , Barrett Barnes , Emily McGowan , Sana Syed , Donald E. Brown

Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory condition of the esophagus associated with elevated esophageal eosinophils. Second only to gastroesophageal reflux disease, EoE is one of the leading causes of chronic…

Goal: Eosinophilic esophagitis (EoE) is an allergic inflammatory condition characterized by eosinophil accumulation in the esophageal mucosa. EoE diagnosis includes a manual assessment of eosinophil levels in mucosal biopsies - a…

Computer Vision and Pattern Recognition · Computer Science 2021-01-14 Tomer Czyzewski , Nati Daniel , Mark Rochman , Julie M. Caldwell , Garrett A. Osswald , Margaret H. Collins , Marc E. Rothenberg , Yonatan Savir

Eosinophilic Esophagitis (EoE) is an allergic condition increasing in prevalence. To diagnose EoE, pathologists must find 15 or more eosinophils within a single high-power field (400X magnification). Determining whether or not a patient has…

Image and Video Processing · Electrical Eng. & Systems 2023-11-09 Kevin Lin , Donald Brown , Sana Syed , Adam Greene

Eosinophilic esophagitis (EoE) is a chronic esophageal disorder marked by eosinophil-dominated inflammation. Diagnosing EoE usually involves endoscopic inspection of the esophageal mucosa and obtaining esophageal biopsies for histologic…

Image and Video Processing · Electrical Eng. & Systems 2025-02-07 Juming Xiong , Hou Xiong , Quan Liu , Ruining Deng , Regina N Tyree , Girish Hiremath , Yuankai Huo

Chronic rhinosinusitis (CRS) is characterized by persistent inflammation in the paranasal sinuses, leading to typical symptoms of nasal congestion, facial pressure, olfactory dysfunction, and discolored nasal drainage, which can…

Image and Video Processing · Electrical Eng. & Systems 2024-11-26 Yifei Wu , Juming Xiong , Tianyuan Yao , Ruining Deng , Junlin Guo , Jialin Yue , Naweed Chowdhury , Yuankai Huo

Eosinophilic esophagitis (EoE) is a chronic, food antigen-driven, allergic inflammatory condition of the esophagus associated with elevated esophageal eosinophils. EoE is a top cause of chronic dysphagia after GERD. Diagnosis of EoE relies…

Eosinophilic Esophagitis (EoE) represents a challenging condition for medical providers today. The cause is currently unknown, the impact on a patient's daily life is significant, and it is increasing in prevalence. Traditional approaches…

Image and Video Processing · Electrical Eng. & Systems 2024-03-19 Kevin Lin , Donald Brown , Sana Syed , Adam Greene

Circle representation has recently been introduced as a medical imaging optimized representation for more effective instance object detection on ball-shaped medical objects. With its superior performance on instance detection, it is…

Computer Vision and Pattern Recognition · Computer Science 2022-11-03 Ethan H. Nguyen , Haichun Yang , Zuhayr Asad , Ruining Deng , Agnes B. Fogo , Yuankai Huo

Recently, circle representation has been introduced for medical imaging, designed specifically to enhance the detection of instance objects that are spherically shaped (e.g., cells, glomeruli, and nuclei). Given its outstanding…

Computer Vision and Pattern Recognition · Computer Science 2025-10-27 Juming Xiong , Ethan H. Nguyen , Yilin Liu , Ruining Deng , Regina N Tyree , Hernan Correa , Girish Hiremath , Yaohong Wang , Haichun Yang , Agnes B. Fogo , Yuankai Huo

Normally eosinophils are present in the gastrointestinal (GI) tract of healthy individuals. When the eosinophils increase beyond their usual amount in the GI tract, a patient gets varied symptoms. Clinicians find it difficult to diagnose…

Quantitative Methods · Quantitative Biology 2022-11-30 Harsh Shah , Thomas Jacob , Amruta Parulekar , Anjali Amarapurkar , Amit Sethi

Accurate segmentation of lesions is crucial for diagnosis and treatment of early esophageal cancer (EEC). However, neither traditional nor deep learning-based methods up to today can meet the clinical requirements, with the mean Dice score…

Image and Video Processing · Electrical Eng. & Systems 2023-06-12 Haipeng Li , Dingrui Liu , Yu Zeng , Shuaicheng Liu , Tao Gan , Nini Rao , Jinlin Yang , Bing Zeng

Oral epithelial dysplasia (OED) is a premalignant histopathological diagnosis given to lesions of the oral cavity. OED grading is subject to large inter/intra-rater variability, resulting in the under/over-treatment of patients. We…

Cytology is a valuable tool for early detection of oral squamous cell carcinoma (OSCC). However, manual examination of cytology whole slide images (WSIs) is slow, subjective, and depends heavily on expert pathologists. To address this, we…

Image and Video Processing · Electrical Eng. & Systems 2025-11-18 Rupam Mukherjee , Rajkumar Daniel , Soujanya Hazra , Shirin Dasgupta , Subhamoy Mandal

Incompletely-Supervised Concealed Object Segmentation (ISCOS) involves segmenting objects that seamlessly blend into their surrounding environments, utilizing incompletely annotated data, such as weak and semi-annotations, for model…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 Chunming He , Kai Li , Yachao Zhang , Ziyun Yang , Youwei Pang , Longxiang Tang , Chengyu Fang , Yulun Zhang , Linghe Kong , Xiu Li , Sina Farsiu

Pancreatic cancer is a lethal form of cancer that significantly contributes to cancer-related deaths worldwide. Early detection is essential to improve patient prognosis and survival rates. Despite advances in medical imaging techniques,…

Image and Video Processing · Electrical Eng. & Systems 2023-12-29 Abhijit Ramesh , Anantha Nandanan , Nikhil Boggavarapu , Priya Nair MD , Gilad Gressel

Oral cancer is a significant global health burden, and early detection remains a critical clinical need. Electrical impedance spectroscopy (EIS) offers a promising non-invasive approach for real-time tissue characterization, but…

Digital pathology enables remote access or consults and powerful image analysis algorithms. However, the slide digitization process can create artifacts such as out-of-focus (OOF). OOF is often only detected upon careful review, potentially…

Computer Vision and Pattern Recognition · Computer Science 2020-06-03 Timo Kohlberger , Yun Liu , Melissa Moran , Po-Hsuan , Chen , Trissia Brown , Craig H. Mermel , Jason D. Hipp , Martin C. Stumpe
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