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Cell deformability is an essential determinant for tissue-scale mechanical nature, such as fluidity and rigidity, and is thus crucial for understanding tissue homeostasis and stable developmental processes. However, numerical simulations…

Tissues and Organs · Quantitative Biology 2023-03-08 Nen Saito , Shuji Ishihara

Recent experiments and numerical studies have drawn attention to the dynamics of active nematics. Two-dimensional active nematics flow spontaneously and exhibit spatiotemporal chaotic flows with proliferation of topological defects in the…

Soft Condensed Matter · Physics 2020-07-08 Farzan Vafa , Mark J. Bowick , M. Cristina Marchetti , Boris I. Shraiman

Cell monolayers are a central model system to tissue biophysics. In vivo, epithelial tissues are curved on the scale of microns, and curvature's role in the onset of spontaneous tissue flows is still not well-understood. Here, we present a…

Biological Physics · Physics 2022-09-21 Samuel Bell , Shao-Zhen Lin , Jean-François Rupprecht , Jacques Prost

There is now growing evidence of the emergence and biological functionality of liquid crystal features, including nematic order and topological defects, in cellular tissues. However, how such features that intrinsically rely on particle…

Soft Condensed Matter · Physics 2019-02-06 Romain Mueller , Julia Yeomans , Amin Doostmohammadi

The structure and dynamics of important biological quasi-two-dimensional systems, ranging from cytoskeletal gels to tissues, are controlled by nematic order, flow, defects and activity. Continuum hydrodynamic descriptions combined with…

Biological Physics · Physics 2024-12-03 Waleed Mirza , Alejandro Torres-Sánchez , Guillermo Vilanova , Marino Arroyo

Active nematic models explain the topological defects and flow patterns observed in epithelial tissues, but the nature of active stress-whether it is extensile or contractile, a key parameter of the theory-is not well established…

Soft Condensed Matter · Physics 2025-11-11 Jan Rozman , Sumesh P. Thampi , Julia M. Yeomans

Dense, active systems show active turbulence, a state characterised by flow fields that are chaotic, with continually changing velocity jets and swirls. Here we review our current understanding of active turbulence. The development is…

Soft Condensed Matter · Physics 2016-08-03 Sumesh P. Thampi , Julia M. Yeomans

We develop a continuum theory to describe the collective dynamics of deformable epithelial cells, using two tensor order parameters to distinguish the force-generating active filaments in the cells from their shape. The theory demonstrates…

Soft Condensed Matter · Physics 2025-01-13 Mehrana R. Nejad , Julia M. Yeomans , Sumesh P Thampi

We consider active nematodynamics on deformable surfaces. Based on a thermodynamically consistent surface Beris-Edwards model we add nematic activity and focus on the emerging additional coupling mechanism between the nematic field, the…

Soft Condensed Matter · Physics 2024-05-24 Ingo Nitschke , Axel Voigt

We present a hydrodynamic theory to describe shear flows in developing epithelial tissues. We introduce hydrodynamic fields corresponding to state properties of constituent cells as well as a contribution to overall tissue shear flow due to…

Models for fluid deformable surfaces provide valid theories to describe the dynamics of thin fluidic sheets of soft materials. To use such models in morphogenesis and development requires to incorporate active forces. We consider active…

Mathematical Physics · Physics 2024-08-20 Maik Porrmann , Axel Voigt

We consider the dynamics of active nematics droplets on flat surfaces, based on the continuum hydrodynamic theory. We investigate a wide range of dynamical regimes as a function of the activity and droplet size on surfaces characterized by…

Soft Condensed Matter · Physics 2023-09-11 Rodrigo C. V. Coelho , Hélio R. J. C. Figueiredo , Margarida M. Telo da Gama

Active matter consumes energy from the environment and transforms it into mechanical work. Notable examples from biology include cell division, bacterial swarms, and muscle contraction. In this work, we investigate the nature of active…

Soft Condensed Matter · Physics 2023-09-28 Michael J. Landry

We investigate similarities in the micro-structural dynamics between externally driven and actively driven nematics. Walls, lines of strong deformations in the director field, and topological defects are characteristic features of an active…

Soft Condensed Matter · Physics 2015-04-28 Sumesh P. Thampi , Ramin Golestanian , Julia M. Yeomans

Inspired by dense contractile tissues, where cells are subject to periodic deformation, we formulate and study a generic hydrodynamic theory of pulsating active liquids. Combining mechanical and phenomenological arguments, we postulate that…

Soft Condensed Matter · Physics 2025-09-25 Tirthankar Banerjee , Thibault Desaleux , Jonas Ranft , Étienne Fodor

Cells are fundamental building blocks of living organisms displaying an array of shapes, morphologies, and textures that encode specific functions and physical behaviors. Elucidating the rules of this code remains a challenge. In this work,…

Active nematics are microscopically driven liquid crystals that exhibit dynamical steady states characterized by the creation and annihilation of topological defects. Motivated by experimental realizations of such systems made of biopolymer…

Soft Condensed Matter · Physics 2018-09-05 Abhijeet Joshi , Elias Putzig , Aparna Baskaran , Michael Hagan

We review progress in active hydrodynamic descriptions of flowing media on curved and deformable manifolds: the state-of-the-art in continuum descriptions of single-layers of epithelial and/or other tissues during development. First, after…

Biological Physics · Physics 2021-03-24 Sami C. Al-Izzi , Richard G. Morris

Engineering synthetic materials that mimic the remarkable complexity of living organisms is a fundamental challenge in science and technology. We study the spatiotemporal patterns that emerge when an active nematicfilm of microtubules and…

In these Lecture Notes we aim at clarifying how soft matter physics, and herein notably statistical mechanics and fluid mechanics, can be engaged to understand and manipulate non-equilibrium systems consisting of numerous (microscopic)…

Soft Condensed Matter · Physics 2025-05-27 Jean-François Joanny , Joseph O. Indekeu
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