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Epithelial cell monolayers show remarkable displacement and velocity correlations over distances of ten or more cell sizes that are reminiscent of supercooled liquids and active nematics. We show that many observed features can be described…

Soft Condensed Matter · Physics 2020-04-22 Silke Henkes , Kaja Kostanjevec , J. Martin Collinson , Rastko Sknepnek , Eric Bertin

In development and homeostasis, multi-cellular systems exhibit spatial and temporal heterogeneity in their biochemical and mechanical properties. Nevertheless, it remains unclear how spatiotemporally heterogeneous forces affect the…

Soft Condensed Matter · Physics 2022-02-18 Takaki Yamamoto , Daniel M. Sussman , Tatsuo Shibata , M. Lisa Manning

Biological tissues are active materials whose non-equilibrium dynamics emerge from distinct cellular force-generating mechanisms. Using a two-dimensional active foam model, we compare the effects of traction forces and junctional tension…

Biological Physics · Physics 2026-04-14 Alessandro Rizzi , Sangwoo Kim

We derive the hydrodynamic equations for nematic liquid crystals lying on curved substrates. We invoke the Lagrange-Rayleigh variational principle to adapt the Ericksen-Leslie theory to two-dimensional nematics in which a degenerate…

Soft Condensed Matter · Physics 2016-08-24 Gaetano Napoli , Luigi Vergori

The shapes of epithelial tissues result from a complex interplay of contractile forces in the cytoskeleta of the cells in the tissue, and adhesion forces between them. A host of discrete, cell-based models describe these forces by assigning…

Soft Condensed Matter · Physics 2019-02-27 Pierra A. Haas , Raymond E. Goldstein

A micrometer-scale elastic shell immersed in a nematic liquid crystal may be deformed by the host if the cost of deformation is comparable to the cost of elastic deformation of the nematic. Moreover, such inclusions interact and form chains…

Soft Condensed Matter · Physics 2018-03-07 Andrew DeBenedictis , Andrea L. Rodarte , Linda S. Hirst , Timothy J. Atherton

Active particles under soft confinement such as droplets or vesicles present intriguing phenomena, as collective motion emerges alongside the deformation of the environment. A model is employed to systematically investigate droplet…

Soft Condensed Matter · Physics 2024-07-25 Javier Diaz , Ignacio Pagonabarraga

Active nematic fluids confined in narrow channels generate spontaneous flows when the activity is sufficiently intense. Recently, it was shown that if the molecular anchoring at the channel walls is conflicting flows are initiated even in…

Soft Condensed Matter · Physics 2021-11-02 C. Rorai , F. Toschi , I. Pagonabarraga

The accumulation of self-propelled particles on repulsive barriers is a widely observed feature in active matter. Despite being implicated in a broad range of biological processes, from biofilm formation to cytoskeletal movement, wetting of…

Statistical Mechanics · Physics 2025-12-12 Noah Grodzinski , Michael E. Cates , Robert L. Jack

Growing experimental evidence indicates that topological defects could serve as organizing centers in the morphogenesis of tissues. Here, we provide a quantitative explanation for this phenomenon, rooted in the buckling theory of deformable…

Soft Condensed Matter · Physics 2022-04-21 Ludwig A. Hoffmann , Livio Nicola Carenza , Julia Eckert , Luca Giomi

Many vesicles have a spherical resting shape and exposure to fluid flows induces an exchange between sub-optical area and visible (systematic) deformation, while the total area is conserved. The dynamics which controls the exchange between…

Soft Condensed Matter · Physics 2020-06-19 Afsoun Rahnama Falavarjani , David Salac

Recent experiments on active materials, such as dense bacterial suspensions and microtubule-kinesin motor mixtures, show a promising potential for achieving self-sustained flows. However, to develop active microfluidics it is necessary to…

Soft Condensed Matter · Physics 2019-01-23 Santhan Chandragiri , Amin Doostmohammadi , Julia M Yeomans , Sumesh P Thampi

Active solids such as cell collectives, colloidal clusters, and active metamaterials exhibit diverse collective phenomena, ranging from rigid body motion to shape-changing mechanisms. The nonlinear dynamics of such active materials remains…

Soft Condensed Matter · Physics 2024-06-21 Claudio Hernández-López , Paul Baconnier , Corentin Coulais , Olivier Dauchot , Gustavo Düring

We derive a fully covariant theory of the mechanics of active surfaces. This theory provides a framework for the study of active biological or chemical processes at surfaces, such as the cell cortex, the mechanics of epithelial tissues, or…

Biological Physics · Physics 2017-09-13 Guillaume Salbreux , Frank Jülicher

Animal morphogenesis often involves significant shape changes of epithelial tissue sheets. Great progress has been made in understanding the underlying cellular driving forces and their coordination through biomechanical feedback loops.…

Soft Condensed Matter · Physics 2024-09-23 Nikolas H. Claussen , Fridtjof Brauns

Cell migration is fundamental to development, tissue organization, immune response, and disease progression. Amoeboid motility is distinguished by rapid motion and strongly fluctuating cell shapes, reflecting the intrinsically nonlinear…

Soft Condensed Matter · Physics 2026-05-19 Winfried Schmidt , Chaouqi Misbah , Alexander Farutin

Efficient nutrient mixing is crucial for the survival of bacterial colonies and other living systems. This raises the question of whether the optimization of mixing through the emergence of active turbulent motion in bacterial swarms played…

Soft Condensed Matter · Physics 2022-09-27 Rodrigo C. V. Coelho , Nuno A. M. Araújo , Margarida M. Telo da Gama

Active fluids exhibit spontaneous flows with complex spatiotemporal structure, which have been observed in bacterial suspensions, sperm cells, cytoskeletal suspensions, self-propelled colloids, and cell tissues. Despite occurring in the…

Soft Condensed Matter · Physics 2022-10-05 Ricard Alert , Jaume Casademunt , Jean-François Joanny

We present a general dynamical theory of a membrane coupled to an actin cortex containing polymerizing filaments with active stresses and currents, and demonstrate that active membrane dynamics [Phys. Rev. Lett \textbf{84}, 3494 (2000)] and…

Biological Physics · Physics 2015-06-18 Ananyo Maitra , Pragya Srivastava , Madan Rao , Sriram Ramaswamy

In vivo and in vitro systems of cells and extra-cellular matrix (ECM) systems are well known to form ordered patterns of orientationally aligned fibers. Here, we interpret them as active analogs of the (disordered) isotropic to the…

Soft Condensed Matter · Physics 2025-04-11 Haiqian Yang , Ming Guo , L. Mahadevan
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