Related papers: Implementing Immune Repertoire Models Using Weight…
In order to target threatening pathogens, the adaptive immune system performs a continuous reorganization of its lymphocyte repertoire. Following an immune challenge, the B cell repertoire can evolve cells of increased specificity for the…
Finite-state models, such as finite-state machines (FSMs), aid software engineering in many ways. They are often used in formal verification and also can serve as visual software models. The latter application is associated with the…
The biological immune system is a robust, complex, adaptive system that defends the body from foreign pathogens. It is able to categorize all cells (or molecules) within the body as self-cells or non-self cells. It does this with the help…
Various studies have shown that immune system inspired hypermutation operators can allow artificial immune systems (AIS) to be very efficient at escaping local optima of multimodal optimisation problems. However, this efficiency comes at…
Repertoire-level analysis of T cell receptors offers a biologically grounded signal for disease detection and immune monitoring, yet practical deployment is impeded by label sparsity, cohort heterogeneity, and the computational burden of…
The biological immune system is a robust, complex, adaptive system that defends the body from foreign pathogens. It is able to categorize all cells (or molecules) within the body as self-cells or non-self cells. It does this with the help…
Reinforcement learning (RL) for large language models (LLMs) is dominated by the cost of rollout generation, which has motivated the use of low-precision rollouts (e.g., FP8) paired with a BF16 trainer to improve throughput and reduce…
The biological immune system is a robust, complex, adaptive system that defends the body from foreign pathogens. It is able to categorize all cells (or molecules) within the body as self or non-self substances. It does this with the help of…
Humans can quickly associate stimuli to solve problems in novel contexts. Our novel neural network model learns state representations of facts that can be composed to perform such associative inference. To this end, we augment the LSTM…
Finite state machines are widely used as a sound mathematical formalism that appropriately describes large scale, distributed and complex systems. Multiple interactions of finite state machines in complex systems are well captured by the…
Extended finite state machines (EFSMs) model stateful systems with internal data variables and have numerous applications in software engineering. A major advantage of this type of model lies in its ability to model both the data flow and…
The major function of this model is to access the UCI Wisconsin Breast Can- cer data-set[1] and classify the data items into two categories, which are normal and anomalous. This kind of classifi cation can be referred as anomaly detection,…
Artificial immune systems (AISs) to date have generally been inspired by naive biological metaphors. This has limited the effectiveness of these systems. In this position paper two ways in which AISs could be made more biologically…
This study investigates large language model (LLM) -based multi-agent systems (MASs) as a promising approach to inventory management, which is a key component of supply chain management. Although these systems have gained considerable…
Our main purpose is to compare classical nonself-centered, two-signal theoretical models of the adaptive immune system with a novel, self-centered, one-signal model developed by our research group. Our model hypothesizes that the immune…
This paper presents an active inference method for Extended Finite State Machines, where inputs and outputs are parametrized, and transitions can be conditioned by guards involving input parameters and internal variables called registers.…
Probabilistic modeling is fundamental to the statistical analysis of complex data. In addition to forming a coherent description of the data-generating process, probabilistic models enable parameter inference about given data sets. This…
Foundation models (FMs) are catalyzing a transformative shift in materials science (MatSci) by enabling scalable, general-purpose, and multimodal AI systems for scientific discovery. Unlike traditional machine learning models, which are…
The adaptive immune system recognizes antigens via an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interrogation of immune repertoires is of high relevance for understanding the adaptive…
Artificial Immune Systems (AIS) employing hypermutations with linear static mutation potential have recently been shown to be very effective at escaping local optima of combinatorial optimisation problems at the expense of being slower…