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In water monitoring, environmental analysis, cell culture stability, and biomedical applications, precise pH control is demanded. Traditional methods like pH strips and meters have limitations: pH strips lack precision, while…

Micro-fluidic pumps as well as artificial micro-swimmers are conveniently realized exploiting phoretic solvent flows based on local gradients of temperature, electrolyte concentration or pH. We here present a facile micro-photometric method…

Soft Condensed Matter · Physics 2018-01-17 Ran Niu , Stanislav Khodorov , Julian Weber , Alexander Reinmüller , Thomas Palberg

Physiological sensing deep in tissue, remains a clinical challenge. Here a flexible miniaturised sensing optrode providing a platform to perform minimally invasive in vivo in situ measurements is reported. Silica microspheres covalently…

An accurate map of intracellular organelle pH is crucial for comprehending cellular metabolism and organellar functions. However, a unified intracellular pH spectrum using a single probe is still lack. Here, we developed a novel quantum…

Quantitative Methods · Quantitative Biology 2024-07-08 Shu-Ang Li , Xiao-Yan Meng , Su Zhang , Ying-Jie Zhang , Run-Zhou Yang , Dian-Dian Wang , Yang Yang , Pei-Pei Liu , Jian-Sheng Kang

The detection of extracellular pH at single cell resolution is challenging and requires advanced sensibility. Sensing pH at a high spatial and temporal resolution might provide crucial information in understanding the role of pH and its…

Real-time and accurate monitoring of humidity and pH is of great significance in daily life and industrial production. Existing humidity and pH measurement suffer from limitations such as low sensitivity, signal crosstalk, complex system…

Applied Physics · Physics 2025-11-07 Jia Liu , Jiawen Zhang , Xiyu Liu , Qi Meng , Riming Xu , Jin Wang

Spatial separation of suspended particles based on contrast in their physical or chemical properties forms the basis of various biological assays performed on lab-on-achip devices. To electronically acquire this information, we have…

Emerging Technologies · Computer Science 2018-08-13 Ningquan Wang , Ruxiu Liu , Roozbeh Khodambashi , Norh Asmare , A. Fatih Sarioglu

Cell spheroids are in vitro multicellular model systems that mimic the crowded micro-environment of biological tissues. Their mechanical characterization can provide valuable insights in how single-cell mechanics and cell-cell interactions…

Quantitative Methods · Quantitative Biology 2022-11-21 R. C. Boot , A. Roscani , L. van Buren , S. Maity , G. H. Koenderink , P. E. Boukany

Despite numerous advances in the field of tissue engineering and regenerative medicine, monitoring the formation of tissue regeneration and its metabolic variations during culture is still a challenge and mostly limited to bulk volumetric…

As modern electronic devices are increasingly miniaturized and integrated, their performance relies more heavily on effective thermal management. Two-phase cooling methods enhanced by porous surfaces, which capitalize on thin-film…

Machine Learning · Computer Science 2023-10-31 Jonathan Tammer Eweis-LaBolle , Chuanning Zhao , Yoonjin Won , Ramin Bostanabad

Precisely measuring pressure in microfluidic flows is essential for flow control, fluid characterization, and monitoring, but faces specific challenges such as \RE{achieving} sufficient resolution, non-invasiveness, or ease of use. Here, we…

Droplet microfluidics offers a versatile platform for analyzing liquid samples. Despite its potential, there is a lack of techniques that allow to reliably probe individual circulating droplets. The prospect of combining droplet…

Quantitative Methods · Quantitative Biology 2024-03-08 Marc Sulliger , Jaime Ortega Arroyo , Romain Quidant

A flow-through sensing platform based on open-ended porous silicon (PSi) microcavity membranes that are compatible with integration in on-chip sensor arrays is demonstrated. Due to the high aspect ratio of PSi nanopores, the performance of…

Materials Science · Physics 2016-10-27 Yiliang Zhao , Girija Gaur , Scott T. Retterer , Paul E. Laibinis , Sharon M. Weiss

We present a high-throughput microfluidic platform capable of quantitating up to 384 biomarkers in 4 distinct samples by immunoassay. The microfluidic device contains 384 unit cells, which can be individually programmed with pairs of…

Quantitative Methods · Quantitative Biology 2015-06-23 Francesca Volpetti , Jose Garcia-Cordero , Sebastian Maerkl

Reliable hardware connectivity is vital in heterogeneous integrated systems. For example, in digital microfluidics lab-on-a-chip systems, there are hundreds of physical connections required between a micro-electro-mechanical fabricated…

Systems and Control · Electrical Eng. & Systems 2020-04-15 Chunjie Zhang , Yang Su , Siyi Hu , Kai Jin , Yuhan Jie , Wenshi Li , Arokia Nathan , Hanbin Ma

There is a crucial need for effective and easily dispersible colloidal microsensors able to detect local pH changes before irreversible damages caused by demineralization, corrosion, or biofilms occur. One class of such microsensors is…

Applied Physics · Physics 2024-09-05 C. A. S. Burel , A. Teolis , A. Alsayed , C. B. Murray , B. Donnio , R. Dreyfus

Molecular Communications (MC), transferring information via chemical signals, holds promise for transformative healthcare applications within the Internet of Bio-Nano Things (IoBNT) framework. Despite promising advances toward practical MC…

Emerging Technologies · Computer Science 2025-02-03 Maide Miray Albay , Eren Akyol , Fariborz Mirlou , Levent Beker , Murat Kuscu

Lab-on-a-Chip (LoC) devices combining microfluidic analyte provision with integrated optical analysis are highly desirable for several applications in biological oder medical sciences. While the microfluidic approach is already broadly…

The integration density of photonic integrated circuits has been limited by light coupling between waveguides. Traditional approaches to layout the waveguide with high density are based on refractive index engineering to suppress the light…

The mechanical properties of biological fluids can serve as early indicators of disease, offering valuable insights into complex physiological and pathological processes. However, the existing technologies can hardly support high throughput…

Optics · Physics 2025-09-18 Zhonghao Li , Zhihan Cai , Chaoyang Gong
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