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Generative pre-trained transformer (GPT) models have revolutionized the field of natural language processing (NLP) with remarkable performance in various tasks and also extend their power to multimodal domains. Despite their success, large…

Computation and Language · Computer Science 2023-08-29 Kaiyuan Gao , Sunan He , Zhenyu He , Jiacheng Lin , QiZhi Pei , Jie Shao , Wei Zhang

The 21st century is presenting humankind with unprecedented environmental and medical challenges. The ability to design novel proteins tailored for specific purposes could transform our ability to respond timely to these issues. Recent…

Biomolecules · Quantitative Biology 2022-08-24 Noelia Ferruz , Birte Höcker

Large language models have recently advanced the state of the art on many natural language processing benchmarks. The newest generation of models can be applied to a variety of tasks with little to no specialized training. This technology…

Databases · Computer Science 2023-06-16 Immanuel Trummer

Large, pre-trained transformer-based language models such as BERT have drastically changed the Natural Language Processing (NLP) field. We present a survey of recent work that uses these large language models to solve NLP tasks via…

Computation and Language · Computer Science 2021-11-03 Bonan Min , Hayley Ross , Elior Sulem , Amir Pouran Ben Veyseh , Thien Huu Nguyen , Oscar Sainz , Eneko Agirre , Ilana Heinz , Dan Roth

There is enormous enthusiasm and concerns in using large language models (LLMs) in healthcare, yet current assumptions are all based on general-purpose LLMs such as ChatGPT. This study develops a clinical generative LLM, GatorTronGPT, using…

DNA language models are increasingly used to represent genomic sequence, yet their effectiveness depends critically on how raw nucleotides are converted into model inputs. Unlike natural language, DNA offers no canonical boundaries, making…

Genomics · Quantitative Biology 2026-05-21 Taewon Kim , Jihwan Shin , Hyomin Kim , Youngmok Jung , Jonghoon Lee , Won-Chul Lee , Sungsoo Ahn , Insu Han

In recent years, advancements in natural language processing (NLP) have been fueled by deep learning techniques, particularly through the utilization of powerful computing resources like GPUs and TPUs. Models such as BERT and GPT-3, trained…

Computation and Language · Computer Science 2024-02-27 Shuning Huo , Yafei Xiang , Hanyi Yu , Mengran Zhu , Yulu Gong

The rapid advancement of large language models, such as the Generative Pre-trained Transformer (GPT) series, has had significant implications across various disciplines. In this study, we investigate the potential of the state-of-the-art…

Computation and Language · Computer Science 2023-09-06 Yunhao Yang , Anshul Tomar

Objective To solve major clinical natural language processing (NLP) tasks using a unified text-to-text learning architecture based on a generative large language model (LLM) via prompt tuning. Methods We formulated 7 key clinical NLP tasks…

Computation and Language · Computer Science 2023-12-12 Cheng Peng , Xi Yang , Aokun Chen , Zehao Yu , Kaleb E Smith , Anthony B Costa , Mona G Flores , Jiang Bian , Yonghui Wu

Natural Language Processing (NLP) has transformed various fields beyond linguistics by applying techniques originally developed for human language to the analysis of biological sequences. This review explores the application of NLP methods…

Computation and Language · Computer Science 2025-06-04 Ella Rannon , David Burstein

Educational materials such as survey articles in specialized fields like computer science traditionally require tremendous expert inputs and are therefore expensive to create and update. Recently, Large Language Models (LLMs) have achieved…

Computation and Language · Computer Science 2024-05-24 Fan Gao , Hang Jiang , Rui Yang , Qingcheng Zeng , Jinghui Lu , Moritz Blum , Dairui Liu , Tianwei She , Yuang Jiang , Irene Li

With the rise of Transformers and Large Language Models (LLMs) in Chemistry and Biology, new avenues for the design and understanding of therapeutics have opened up to the scientific community. Protein sequences can be modeled as language…

Machine Learning · Computer Science 2023-11-01 Seongwon Kim , Parisa Mollaei , Akshay Antony , Rishikesh Magar , Amir Barati Farimani

This research introduces a novel text generation model that combines BERT's semantic interpretation strengths with GPT-4's generative capabilities, establishing a high standard in generating coherent, contextually accurate language. Through…

Computation and Language · Computer Science 2024-11-20 Jiajing Chen , Shuo Wang , Zhen Qi , Zhenhong Zhang , Chihang Wang , Hongye Zheng

Recently, the development of pre-trained language models has brought natural language processing (NLP) tasks to the new state-of-the-art. In this paper we explore the efficiency of various pre-trained language models. We pre-train a list of…

Computation and Language · Computer Science 2023-07-27 Tong Guo

Deep generative models of molecules have grown immensely in popularity, trained on relevant datasets, these models are used to search through chemical space. The downstream utility of generative models for the inverse design of novel…

Machine Learning · Computer Science 2023-05-11 Daniel Flam-Shepherd , Kevin Zhu , Alán Aspuru-Guzik

Large pre-trained language models help to achieve state of the art on a variety of natural language processing (NLP) tasks, nevertheless, they still suffer from forgetting when incrementally learning a sequence of tasks. To alleviate this…

Computation and Language · Computer Science 2023-03-03 Mingxu Tao , Yansong Feng , Dongyan Zhao

We present a comparison of word-based and character-based sequence-to-sequence models for data-to-text natural language generation, which generate natural language descriptions for structured inputs. On the datasets of two recent generation…

Computation and Language · Computer Science 2018-10-12 Glorianna Jagfeld , Sabrina Jenne , Ngoc Thang Vu

Evolution consists of distinct stages: cosmological, biological, linguistic. Since biology verges on natural sciences and linguistics, we expect that it shares structures and features from both forms of knowledge. Indeed, in DNA we…

Other Quantitative Biology · Quantitative Biology 2019-10-01 Argyris Nicolaidis , Fotis Psomopoulos

Significant advancements have been made in one of the most critical branches of artificial intelligence: natural language processing (NLP). These advancements are exemplified by the remarkable success of OpenAI's GPT-3.5/4 and the recent…

Materials Science · Physics 2025-04-22 Zongrui Pei , Junqi Yin , Jiaxin Zhang

We propose an alternate approach to quantifying how well language models learn natural language: we ask how well they match the statistical tendencies of natural language. To answer this question, we analyze whether text generated from…

Computation and Language · Computer Science 2021-08-31 Clara Meister , Ryan Cotterell