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Pre-trained large language models(LLMs) have attracted increasing attention in biomedical domains due to their success in natural language processing. However, the complex traits and heterogeneity of multi-sources genomics data pose…

Computation and Language · Computer Science 2025-11-25 Yanjun Lyu , Zihao Wu , Lu Zhang , Jing Zhang , Yiwei Li , Wei Ruan , Zhengliang Liu , Zeyu Zhang , Xiang Li , Rongjie Liu , Chao Huang , Wentao Li , Tianming Liu , Dajiang Zhu

Recent advances in neural network-based generative modeling have reignited the hopes in having computer systems capable of seamlessly conversing with humans and able to understand natural language. Neural architectures have been employed to…

Computation and Language · Computer Science 2020-08-03 Cristina Garbacea , Qiaozhu Mei

Large language models (LLMs) have notably enhanced the fluency and diversity of machine-generated text. However, this progress also presents a significant challenge in detecting the origin of a given text, and current research on detection…

Computation and Language · Computer Science 2023-10-05 Xianjun Yang , Wei Cheng , Yue Wu , Linda Petzold , William Yang Wang , Haifeng Chen

Pre-trained language models have attracted increasing attention in the biomedical domain, inspired by their great success in the general natural language domain. Among the two main branches of pre-trained language models in the general…

Computation and Language · Computer Science 2023-04-04 Renqian Luo , Liai Sun , Yingce Xia , Tao Qin , Sheng Zhang , Hoifung Poon , Tie-Yan Liu

Recent years have seen a proliferation of attention mechanisms and the rise of Transformers in Natural Language Generation (NLG). Previously, state-of-the-art NLG architectures such as RNN and LSTM ran into vanishing gradient problems; as…

Computation and Language · Computer Science 2021-02-17 M. Onat Topal , Anil Bas , Imke van Heerden

$N$-gram language models (LM) have been largely superseded by neural LMs as the latter exhibits better performance. However, we find that $n$-gram models can achieve satisfactory performance on a large proportion of testing cases,…

Computation and Language · Computer Science 2022-11-04 Huayang Li , Deng Cai , Jin Xu , Taro Watanabe

Random Number Generation Tasks (RNGTs) are used in psychology for examining how humans generate sequences devoid of predictable patterns. By adapting an existing human RNGT for an LLM-compatible environment, this preliminary study tests…

Artificial Intelligence · Computer Science 2024-08-21 Rachel M. Harrison

While discriminative neural network classifiers are generally preferred, recent work has shown advantages of generative classifiers in term of data efficiency and robustness. In this paper, we focus on natural language inference (NLI). We…

Computation and Language · Computer Science 2020-10-09 Xiaoan Ding , Tianyu Liu , Baobao Chang , Zhifang Sui , Kevin Gimpel

Pre-trained transformer language models on large unlabeled corpus have produced state-of-the-art results in natural language processing, organic molecule design, and protein sequence generation. However, no such models have been applied to…

Genomic language models (gLMs) have shown mostly modest success in identifying evolutionarily constrained elements in mammalian genomes. To address this issue, we introduce a novel framework for training gLMs that explicitly models…

Genomics · Quantitative Biology 2026-03-23 Carlos Albors , Jianan Canal Li , Gonzalo Benegas , Chengzhong Ye , Yun S. Song

Recently, Natural Language Processing (NLP) has witnessed an impressive progress in many areas, due to the advent of novel, pretrained contextual representation models. In particular, Devlin et al. (2019) proposed a model, called BERT…

Computation and Language · Computer Science 2020-03-09 Debora Nozza , Federico Bianchi , Dirk Hovy

We consider controllable DNA sequence design, where sequences are generated by conditioning on specific biological properties. While language models (LMs) such as GPT and BERT have achieved remarkable success in natural language generation,…

Machine Learning · Computer Science 2025-12-10 Xingyu Su , Xiner Li , Yuchao Lin , Ziqian Xie , Degui Zhi , Shuiwang Ji

Significant advances have been made in recent years on Natural Language Processing with machines surpassing human performance in many tasks, including but not limited to Question Answering. The majority of deep learning methods for Question…

Machine Learning · Computer Science 2024-09-05 Ayush Jain , N. M. Meenachi , B. Venkatraman

State-of-the-art natural language processing (NLP) models are trained on massive training corpora, and report a superlative performance on evaluation datasets. This survey delves into an important attribute of these datasets: the dialect of…

Computation and Language · Computer Science 2024-12-10 Aditya Joshi , Raj Dabre , Diptesh Kanojia , Zhuang Li , Haolan Zhan , Gholamreza Haffari , Doris Dippold

Gene enhancers control when and where genes switch on, yet their sequence diversity and tissue specificity make them hard to pinpoint in colorectal cancer. We take a sequence-only route and fine-tune DNABERT-2, a transformer genomic…

Genomics · Quantitative Biology 2025-10-01 Darren King , Yaser Atlasi , Gholamreza Rafiee

Large-scale language models such as DNABert and LOGO aim to learn optimal gene representations and are trained on the entire Human Reference Genome. However, standard tokenization schemes involve a simple sliding window of tokens like…

Computation and Language · Computer Science 2023-10-16 Soumyadeep Roy , Jonas Wallat , Sowmya S Sundaram , Wolfgang Nejdl , Niloy Ganguly

Natural language processing (NLP) has been traditionally applied to medicine, and generative large language models (LLMs) have become prominent recently. However, the differences between them across different medical tasks remain…

We present the first experiments on Native Language Identification (NLI) using LLMs such as GPT-4. NLI is the task of predicting a writer's first language by analyzing their writings in a second language, and is used in second language…

Computation and Language · Computer Science 2023-12-14 Wei Zhang , Alexandre Salle

In recent years, groundbreaking advancements in natural language processing have culminated in the emergence of powerful large language models (LLMs), which have showcased remarkable capabilities across a vast array of domains, including…

Computation and Language · Computer Science 2023-12-11 Microsoft Research AI4Science , Microsoft Azure Quantum

Healthcare domain generates a lot of unstructured and semi-structured text. Natural Language processing (NLP) has been used extensively to process this data. Deep Learning based NLP especially Large Language Models (LLMs) such as BERT have…

Computation and Language · Computer Science 2023-01-11 Kunal Suri , Atul Singh , Prakhar Mishra , Swapna Sourav Rout , Rajesh Sabapathy