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Recent advancements in specialized large-scale architectures for training image and language have profoundly impacted the field of computer vision and natural language processing (NLP). Language models, such as the recent ChatGPT and GPT4…

Biomolecules · Quantitative Biology 2023-05-04 Sergio Romero-Romero , Sebastian Lindner , Noelia Ferruz

This study demonstrates that generative large language models can be utilized in a more flexible manner for DNA sequence analysis and classification tasks compared to traditional transformer encoder-based models. While recent encoder-based…

Computation and Language · Computer Science 2025-03-07 Hyunwoo Yoo

The ability to transmit and receive complex information via language is unique to humans and is the basis of traditions, culture and versatile social interactions. Through the disruptive introduction of transformer based large language…

Computation and Language · Computer Science 2024-05-06 Patrick Krauss , Jannik Hösch , Claus Metzner , Andreas Maier , Peter Uhrig , Achim Schilling

In recent years, natural language processing (NLP) models have demonstrated remarkable capabilities in various domains beyond traditional text generation. In this work, we introduce PeptideGPT, a protein language model tailored to generate…

Machine Learning · Computer Science 2024-10-28 Aayush Shah , Chakradhar Guntuboina , Amir Barati Farimani

In recent times, Transformer-based language models are making quite an impact in the field of natural language processing. As relevant parallels can be drawn between biological sequences and natural languages, the models used in NLP can be…

Computation and Language · Computer Science 2025-12-25 Nimisha Ghosh , Daniele Santoni , Indrajit Saha , Giovanni Felici

Multilingual transfer ability, which reflects how well models fine-tuned on one source language can be applied to other languages, has been well studied in multilingual pre-trained models. However, the existence of such capability transfer…

Computation and Language · Computer Science 2025-01-20 Wang Liang

The fields of generative AI and transfer learning have experienced remarkable advancements in recent years especially in the domain of Natural Language Processing (NLP). Transformers have been at the heart of these advancements where the…

Computation and Language · Computer Science 2024-02-28 Majd Saleh , Stéphane Paquelet

Large language models (LLMs) are having transformative impacts across a wide range of scientific fields, particularly in the biomedical sciences. Just as the goal of Natural Language Processing is to understand sequences of words, a major…

Genomics · Quantitative Biology 2024-09-24 Gonzalo Benegas , Chengzhong Ye , Carlos Albors , Jianan Canal Li , Yun S. Song

Large language models (LLMs) trained on text demonstrated remarkable results on natural language processing (NLP) tasks. These models have been adapted to decipher the language of DNA, where sequences of nucleotides act as "words" that…

There are already many DNA large language models, but most of them still follow traditional uses, such as extracting sequence features for classification tasks. More innovative applications of large language models, such as prompt…

Genomics · Quantitative Biology 2024-10-29 Wang Liang

Natural Language Processing (NLP) has witnessed a transformative leap with the advent of transformer-based architectures, which have significantly enhanced the ability of machines to understand and generate human-like text. This paper…

Computation and Language · Computer Science 2025-03-27 Tianhao Wu , Yu Wang , Ngoc Quach

The paradigm of large language models in natural language processing (NLP) has also shown promise in modeling biological languages, including proteins, RNA, and DNA. Both the auto-regressive generation paradigm and evaluation metrics have…

Biomolecules · Quantitative Biology 2025-07-04 Ke Liu , Shuaike Shen , Hao Chen

Recent work has demonstrated substantial gains on many NLP tasks and benchmarks by pre-training on a large corpus of text followed by fine-tuning on a specific task. While typically task-agnostic in architecture, this method still requires…

Since the completion of the human genome sequencing project in 2001, significant progress has been made in areas such as gene regulation editing and protein structure prediction. However, given the vast amount of genomic data, the segments…

Other Quantitative Biology · Quantitative Biology 2025-01-29 Wang Liang

Generative Artificial Intelligence has grown exponentially as a result of Large Language Models (LLMs). This has been possible because of the impressive performance of deep learning methods created within the field of Natural Language…

Phenotype-driven gene prioritization is a critical process in the diagnosis of rare genetic disorders for identifying and ranking potential disease-causing genes based on observed physical traits or phenotypes. While traditional approaches…

Quantitative Methods · Quantitative Biology 2024-04-04 Junyoung Kim , Jingye Yang , Kai Wang , Chunhua Weng , Cong Liu

In recent years, Natural Language Processing (NLP) models have achieved phenomenal success in linguistic and semantic tasks like text classification, machine translation, cognitive dialogue systems, information retrieval via Natural…

Computation and Language · Computer Science 2021-05-18 Sushant Singh , Ausif Mahmood

This open access book provides a comprehensive overview of the state of the art in research and applications of Foundation Models and is intended for readers familiar with basic Natural Language Processing (NLP) concepts. Over the recent…

Computation and Language · Computer Science 2023-02-20 Gerhard Paaß , Sven Giesselbach

Foundation models have revolutionized natural language processing and artificial intelligence, significantly enhancing how machines comprehend and generate human languages. Inspired by the success of these foundation models, researchers…

Pre-trained large language models demonstrate potential in extracting information from DNA sequences, yet adapting to a variety of tasks and data modalities remains a challenge. To address this, we propose DNAGPT, a generalized DNA…

Genomics · Quantitative Biology 2023-09-01 Daoan Zhang , Weitong Zhang , Yu Zhao , Jianguo Zhang , Bing He , Chenchen Qin , Jianhua Yao
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