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Deep learning models have achieved promising results in breast cancer classification, yet their 'black-box' nature raises interpretability concerns. This research addresses the crucial need to gain insights into the decision-making process…

Computer Vision and Pattern Recognition · Computer Science 2024-08-26 Ann-Kristin Balve , Peter Hendrix

The lack of interpretability in the field of medical image analysis has significant ethical and legal implications. Existing interpretable methods in this domain encounter several challenges, including dependency on specific models,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-30 Lijie Hu , Songning Lai , Wenshuo Chen , Hongru Xiao , Hongbin Lin , Lu Yu , Jingfeng Zhang , Di Wang

We introduce ProtoSeg, a novel model for interpretable semantic image segmentation, which constructs its predictions using similar patches from the training set. To achieve accuracy comparable to baseline methods, we adapt the mechanism of…

Computer Vision and Pattern Recognition · Computer Science 2025-06-30 Mikołaj Sacha , Dawid Rymarczyk , Łukasz Struski , Jacek Tabor , Bartosz Zieliński

Recent deep learning methods for fMRI-based diagnosis have achieved promising accuracy by modeling functional connectivity networks. However, standard approaches often struggle with noisy interactions, and conventional post-hoc attribution…

Machine Learning · Computer Science 2026-02-25 Kunyu Zhang , Yanwu Yang , Jing Zhang , Xiangjie Shi , Shujian Yu

Automated medical image segmentation plays an important role in many clinical applications, which however is a very challenging task, due to complex background texture, lack of clear boundary and significant shape and texture variation…

Image and Video Processing · Electrical Eng. & Systems 2020-10-26 Qikui Zhu , Liang Li , Jiangnan Hao , Yunfei Zha , Yan Zhang , Yanxiang Cheng , Fei Liao , Pingxiang Li

Current machine learning has made great progress on computer vision and many other fields attributed to the large amount of high-quality training samples, while it does not work very well on genomic data analysis, since they are notoriously…

Machine Learning · Computer Science 2020-09-04 Ziyi Yang , Jun Shu , Yong Liang , Deyu Meng , Zongben Xu

Interpretability of machine learning models is critical for data-driven precision medicine efforts. However, highly predictive models are generally complex and are difficult to interpret. Here using Model-Agnostic Explanations algorithm, we…

Quantitative Methods · Quantitative Biology 2016-10-31 Gajendra Jung Katuwal , Robert Chen

Artificial neural networks have proven to be extremely useful models that have allowed for multiple recent breakthroughs in the field of Artificial Intelligence and many others. However, they are typically regarded as black boxes, given how…

Artificial Intelligence · Computer Science 2023-03-07 Manuel de Sousa Ribeiro , João Leite

Prototypical part network (ProtoPNet) has drawn wide attention and boosted many follow-up studies due to its self-explanatory property for explainable artificial intelligence (XAI). However, when directly applying ProtoPNet on vision…

Computer Vision and Pattern Recognition · Computer Science 2025-11-27 Mengqi Xue , Qihan Huang , Haofei Zhang , Jingwen Hu , Jie Song , Mingli Song , Canghong Jin

We consider the problem of image classification for the purpose of aiding doctors in dermatological diagnosis. Dermatological diagnosis poses two major challenges for standard off-the-shelf techniques: First, the data distribution is…

Computer Vision and Pattern Recognition · Computer Science 2018-11-08 Viraj Prabhu , Anitha Kannan , Murali Ravuri , Manish Chablani , David Sontag , Xavier Amatriain

Cancers are the leading cause of death in many countries. Early diagnosis plays a crucial role in having proper treatment for this debilitating disease. The automated classification of the type of cancer is a challenging task since…

Image and Video Processing · Electrical Eng. & Systems 2021-08-20 Hosein Barzekar , Zeyun Yu

Prototypical part network (ProtoPNet) methods have been designed to achieve interpretable classification by associating predictions with a set of training prototypes, which we refer to as trivial prototypes because they are trained to lie…

Computer Vision and Pattern Recognition · Computer Science 2023-10-24 Chong Wang , Yuyuan Liu , Yuanhong Chen , Fengbei Liu , Yu Tian , Davis J. McCarthy , Helen Frazer , Gustavo Carneiro

Automated skin lesion classification using deep learning has shown remarkable accuracy, yet clinical adoption remains limited due to the "black box" nature of these models. We present MelanomaNet, an explainable deep learning system for…

Computer Vision and Pattern Recognition · Computer Science 2025-12-11 Sukhrobbek Ilyosbekov

Recent advancements in artificial intelligence (AI) have facilitated its widespread adoption in primary medical services, addressing the demand-supply imbalance in healthcare. Vision Transformers (ViT) have emerged as state-of-the-art…

Computer Vision and Pattern Recognition · Computer Science 2023-09-04 Tin Lai

Medical images differ from natural images in significantly higher resolutions and smaller regions of interest. Because of these differences, neural network architectures that work well for natural images might not be applicable to medical…

Computer Vision and Pattern Recognition · Computer Science 2020-02-19 Yiqiu Shen , Nan Wu , Jason Phang , Jungkyu Park , Kangning Liu , Sudarshini Tyagi , Laura Heacock , S. Gene Kim , Linda Moy , Kyunghyun Cho , Krzysztof J. Geras

In this introductory article we present the basics of an approach to implementing computational interpreting of natural language aiming to model the meanings of words and phrases. Unlike other approaches, we attempt to define the meanings…

Computation and Language · Computer Science 2019-08-12 Michael Kapustin , Pavlo Kapustin

Deep learning has shown promising results in medical image analysis, however, the lack of very large annotated datasets confines its full potential. Although transfer learning with ImageNet pre-trained classification models can alleviate…

Computer Vision and Pattern Recognition · Computer Science 2018-08-16 Ken C. L. Wong , Tanveer Syeda-Mahmood , Mehdi Moradi

Interpretable deep learning is a fundamental building block towards safer AI, especially when the deployment possibilities of deep learning-based computer-aided medical diagnostic systems are so eminent. However, without a computational…

Machine Learning · Computer Science 2018-06-27 Anirban Mukhopadhyay

Prototype models are an important method for explainable artificial intelligence (XAI) and interpretable machine learning. In this paper, we perform an in-depth analysis of a set of prominent prototype models including ProtoPNet, ProtoPool…

Machine Learning · Computer Science 2025-11-24 Philipp Schlinge , Steffen Meinert , Martin Atzmueller

Interpretability is a key requirement for the use of machine learning models in high-stakes applications, including medical diagnosis. Explaining black-box models mostly relies on post-hoc methods that do not faithfully reflect the model's…

Artificial Intelligence · Computer Science 2024-06-25 Kerol Djoumessi , Bubacarr Bah , Laura Kühlewein , Philipp Berens , Lisa Koch