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How to interpret a data mining model has received much attention recently, because people may distrust a black-box predictive model if they do not understand how the model works. Hence, it will be trustworthy if a model can provide…

Machine Learning · Computer Science 2025-03-20 Zengyou He , Pengju Li , Yifan Tang , Lianyu Hu , Mudi Jiang , Yan Liu

Understanding the spatial architecture of the tumor microenvironment (TME) is critical to advance precision oncology. We present ProteinPNet, a novel framework based on prototypical part networks that discovers TME motifs from spatial…

Machine Learning · Computer Science 2025-12-03 Louis McConnell , Jieran Sun , Theo Maffei , Raphael Gottardo , Marianna Rapsomaniki

Vision models are interpretable when they classify objects on the basis of features that a person can directly understand. Recently, methods relying on visual feature prototypes have been developed for this purpose. However, in contrast to…

Computer Vision and Pattern Recognition · Computer Science 2019-08-27 Peter Hase , Chaofan Chen , Oscar Li , Cynthia Rudin

Recent advancements in post-hoc and inherently interpretable methods have markedly enhanced the explanations of black box classifier models. These methods operate either through post-analysis or by integrating concept learning during model…

Computer Vision and Pattern Recognition · Computer Science 2024-04-24 Bor-Shiun Wang , Chien-Yi Wang , Wei-Chen Chiu

Interpretability in machine learning models is important in high-stakes decisions, such as whether to order a biopsy based on a mammographic exam. Mammography poses important challenges that are not present in other computer vision tasks:…

Machine Learning · Computer Science 2021-03-24 Alina Jade Barnett , Fides Regina Schwartz , Chaofan Tao , Chaofan Chen , Yinhao Ren , Joseph Y. Lo , Cynthia Rudin

Medical imaging classifiers can achieve high predictive accuracy, but quantifying their uncertainty remains an unresolved challenge, which prevents their deployment in medical clinics. We present an algorithm that can modify any classifier…

Machine Learning · Computer Science 2024-08-12 Roy Hirsch , Jacob Goldberger

Deep learning has driven significant advances in medical image analysis, yet its adoption in clinical practice remains constrained by the large size and lack of transparency in modern models. Advances in interpretability techniques such as…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Nikita Malik , Pratinav Seth , Neeraj Kumar Singh , Chintan Chitroda , Vinay Kumar Sankarapu

Aligning machine representations with human understanding is key to improving interpretability of machine learning (ML) models. When classifying a new image, humans often explain their decisions by decomposing the image into concepts and…

Machine Learning · Computer Science 2025-01-13 Sarath Sivaprasad , Dmitry Kangin , Plamen Angelov , Mario Fritz

We present ProtoViT, a method for interpretable image classification combining deep learning and case-based reasoning. This method classifies an image by comparing it to a set of learned prototypes, providing explanations of the form ``this…

Computer Vision and Pattern Recognition · Computer Science 2025-09-11 Chiyu Ma , Jon Donnelly , Wenjun Liu , Soroush Vosoughi , Cynthia Rudin , Chaofan Chen

Building generalizable AI models is one of the primary challenges in the healthcare domain. While radiologists rely on generalizable descriptive rules of abnormality, Neural Network (NN) models suffer even with a slight shift in input…

Computer Vision and Pattern Recognition · Computer Science 2023-07-12 Shantanu Ghosh , Ke Yu , Kayhan Batmanghelich

Skin cancer detection through dermoscopy image analysis is a critical task. However, existing models used for this purpose often lack interpretability and reliability, raising the concern of physicians due to their black-box nature. In this…

Computer Vision and Pattern Recognition · Computer Science 2024-02-05 Miguel Correia , Alceu Bissoto , Carlos Santiago , Catarina Barata

Human-interpretable predictions are essential for deploying AI in medical imaging, yet most interpretable-by-design (IBD) frameworks require concept annotations for training data, which are costly and impractical to obtain in clinical…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Md Nahiduzzaman , Steven Korevaar , Alireza Bab-Hadiashar , Ruwan Tennakoon

There is a need of ensuring machine learning models that are interpretable. Higher interpretability of the model means easier comprehension and explanation of future predictions for end-users. Further, interpretable machine learning models…

Machine Learning · Computer Science 2020-08-17 Gregor Stiglic , Primoz Kocbek , Nino Fijacko , Marinka Zitnik , Katrien Verbert , Leona Cilar

Interpretability is essential for machine learning algorithms in high-stakes application fields such as medical image analysis. However, high-performing black-box neural networks do not provide explanations for their predictions, which can…

Computer Vision and Pattern Recognition · Computer Science 2023-08-09 Susu Sun , Stefano Woerner , Andreas Maier , Lisa M. Koch , Christian F. Baumgartner

State of the art machine learning algorithms are highly optimized to provide the optimal prediction possible, naturally resulting in complex models. While these models often outperform simpler more interpretable models by order of…

Machine Learning · Statistics 2016-11-24 Yotam Hechtlinger

Medical Image Segmentation (MIS) plays a crucial role in medical therapy planning and robot navigation. Prototype learning methods in MIS focus on generating segmentation masks through pixel-to-prototype comparison. However, current…

Methodology · Statistics 2025-07-11 Guoyan Liang , Qin Zhou , Jingyuan Chen , Zhe Wang , Chang Yao

Neural networks, with powerful nonlinear mapping and classification capabilities, are widely applied in mechanical fault diagnosis to ensure safety. However, being typical black-box models, their application is limited in…

Machine Learning · Computer Science 2025-02-11 Qian Chen , Xingjian Dong , Zhike Peng

We propose DeepMiner, a framework to discover interpretable representations in deep neural networks and to build explanations for medical predictions. By probing convolutional neural networks (CNNs) trained to classify cancer in mammograms,…

Computer Vision and Pattern Recognition · Computer Science 2021-11-02 Jimmy Wu , Bolei Zhou , Diondra Peck , Scott Hsieh , Vandana Dialani , Lester Mackey , Genevieve Patterson

The use of deep neural models for diagnosis prediction from clinical text has shown promising results. However, in clinical practice such models must not only be accurate, but provide doctors with interpretable and helpful results. We…

Deep learning methods, in particular convolutional neural networks, have emerged as a powerful tool in medical image computing tasks. While these complex models provide excellent performance, their black-box nature may hinder real-world…

Image and Video Processing · Electrical Eng. & Systems 2022-10-18 Yuzhe Lu , Adam Perer