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This article presents the prediction difference analysis method for visualizing the response of a deep neural network to a specific input. When classifying images, the method highlights areas in a given input image that provide evidence for…

Computer Vision and Pattern Recognition · Computer Science 2017-02-16 Luisa M Zintgraf , Taco S Cohen , Tameem Adel , Max Welling

Deep neural networks have achieved remarkable performance in various text-based tasks but often lack interpretability, making them less suitable for applications where transparency is critical. To address this, we propose ProtoLens, a novel…

Computation and Language · Computer Science 2024-10-25 Bowen Wei , Ziwei Zhu

The use of deep learning in computer vision tasks such as image classification has led to a rapid increase in the performance of such systems. Due to this substantial increment in the utility of these systems, the use of artificial…

Image and Video Processing · Electrical Eng. & Systems 2023-04-05 Vinay Jogani , Joy Purohit , Ishaan Shivhare , Seema C Shrawne

Deep neural networks (DNN) have achieved unprecedented performance in computer-vision tasks almost ubiquitously in business, technology, and science. While substantial efforts are made to engineer highly accurate architectures and provide…

Image and Video Processing · Electrical Eng. & Systems 2022-09-08 Sumedha Singla

There is a strong need for automated systems to improve diagnostic quality and reduce the analysis time in histopathology image processing. Automated detection and classification of pathological tissue characteristics with computer-aided…

Computer Vision and Pattern Recognition · Computer Science 2019-11-22 Muhammed Talo

Training Artificial Intelligence (AI) models on 3D images presents unique challenges compared to the 2D case: Firstly, the demand for computational resources is significantly higher, and secondly, the availability of large datasets for…

We show a proof of principle for warping, a method to interpret the inner working of neural networks in the context of gene expression analysis. Warping is an efficient way to gain insight to the inner workings of neural nets and make them…

Genomics · Quantitative Biology 2017-08-17 Trofimov Assya , Lemieux Sebastien , Perreault Claude

Medical imaging is an essential tool for diagnosing various healthcare diseases and conditions. However, analyzing medical images is a complex and time-consuming task that requires expertise and experience. This article aims to design a…

Image and Video Processing · Electrical Eng. & Systems 2023-05-15 Ayyub Alzahem , Shahid Latif , Wadii Boulila , Anis Koubaa

Neural networks (NNs) have been successfully applied to solve a variety of application problems involving classification and function approximation. Although backpropagation NNs generally predict better than decision trees do for pattern…

Neural and Evolutionary Computing · Computer Science 2010-09-28 S. M. Kamruzzaman

This paper claims that machine learning models deployed in high stakes domains such as medicine must be interpretable, shareable, reproducible and accountable. We argue that these principles should form the foundational design criteria for…

Machine Learning · Computer Science 2025-08-25 Ayyüce Begüm Bektaş , Mithat Gönen

Understanding how molecular alterations propagate across biological systems to drive disease remains a central challenge. Although high-throughput profiling enables comprehensive characterization of tumor states, most models neglect…

Quantitative Methods · Quantitative Biology 2026-05-11 Kyle Higgins , Guadalupe Gonzalez , Dennis Veselkov , Ivan Laponogov , Kirill Veselkov

Medical imaging plays an important role in the medical sector in identifying diseases. X-ray, computed tomography (CT) scans, and magnetic resonance imaging (MRI) are a few examples of medical imaging. Most of the time, these imaging…

Image and Video Processing · Electrical Eng. & Systems 2024-09-01 Mosabbir Bhuiyan , MD Abdullah Al Nasim , Sarwar Saif , Kishor Datta Gupta , Md Jahangir Alam , Sajedul Talukder

As machine learning becomes an important part of many real world applications affecting human lives, new requirements, besides high predictive accuracy, become important. One important requirement is transparency, which has been associated…

Machine Learning · Computer Science 2019-08-01 Tiago Botari , Rafael Izbicki , Andre C. P. L. F. de Carvalho

Accurate segmentation of anatomical structures and abnormalities in medical images is crucial for computer-aided diagnosis and analysis. While deep learning techniques excel at this task, their computational demands pose challenges.…

Image and Video Processing · Electrical Eng. & Systems 2024-09-24 Syed Javed , Tariq M. Khan , Abdul Qayyum , Hamid Alinejad-Rokny , Arcot Sowmya , Imran Razzak

We present ProtoConcepts, a method for interpretable image classification combining deep learning and case-based reasoning using prototypical parts. Existing work in prototype-based image classification uses a ``this looks like that''…

Computer Vision and Pattern Recognition · Computer Science 2023-10-31 Chiyu Ma , Brandon Zhao , Chaofan Chen , Cynthia Rudin

Deep learning models show promise in digital pathology, but their opaque decision-making processes limit trust and clinical adoption. To address this challenge, we present HIPPO, an explainable AI method for analyzing weakly-supervised…

Tissues and Organs · Quantitative Biology 2025-12-10 Jakub R. Kaczmarzyk , Chanwoo Kim , Soham Gadgil , Deepika Savant , Zhen Zhao , Joel H. Saltz , Su-In Lee , Peter K. Koo

A major prerequisite for the application of machine learning models in clinical decision making is trust and interpretability. Current explainability studies in the neuroimaging community have mostly focused on explaining individual…

Computer Vision and Pattern Recognition · Computer Science 2022-03-25 Fabian Eitel , Anna Melkonyan , Kerstin Ritter

Current AI-assisted skin image diagnosis has achieved dermatologist-level performance in classifying skin cancer, driven by rapid advancements in deep learning architectures. However, unlike traditional vision tasks, skin images in general…

Computer Vision and Pattern Recognition · Computer Science 2025-01-17 Xin Hu , Janet Wang , Jihun Hamm , Rie R Yotsu , Zhengming Ding

In recent years, deep convolutional neural network-based segmentation methods have achieved state-of-the-art performance for many medical analysis tasks. However, most of these approaches rely on optimizing the U-Net structure or adding new…

Image and Video Processing · Electrical Eng. & Systems 2025-09-15 Kunpeng Mao , Ruoyu Li , Junlong Cheng , Danmei Huang , Zhiping Song , ZeKui Liu

In healthcare there is a pursuit for employing interpretable algorithms to assist healthcare professionals in several decision scenarios. Following the Predictive, Descriptive and Relevant (PDR) framework, the definition of interpretable…

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