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Accurate RNA structure modeling remains difficult because RNA backbones are highly flexible, non-canonical interactions are prevalent, and experimentally determined 3D structures are comparatively scarce. We introduce \emph{RiboSphere}, a…

Machine Learning · Computer Science 2026-03-23 Zhou Zhang , Hanqun Cao , Cheng Tan , Fang Wu , Pheng Ann Heng , Tianfan Fu

Spiking Neural Networks (SNNs) provide a promising framework for energy-efficient and biologically grounded computation; however, scalable learning in deep recurrent architectures with sparse connectivity remains a major challenge. In this…

Neural and Evolutionary Computing · Computer Science 2026-05-04 Bo Tang , Weiwei Xie

Powerful deep learning tools, such as convolutional neural networks (CNN), are able to learn the input-output relationships of large complicated systems directly from data. Encoder-decoder deep CNNs are able to extract features directly…

Machine Learning · Statistics 2021-06-08 Alexander Scheinker , Frederick Cropp , Sergio Paiagua , Daniele Filippetto

Recently developed deep learning techniques have significantly improved the accuracy of various speech and image recognition systems. In this paper we show how to adapt some of these techniques to create a novel chained convolutional…

Machine Learning · Computer Science 2017-02-20 Akosua Busia , Navdeep Jaitly

Non-coding RNA structure and function are essential to understanding various biological processes, such as cell signaling, gene expression, and post-transcriptional regulations. These are all among the core problems in the RNA field. With…

Quantitative Methods · Quantitative Biology 2022-08-09 Jiayang Chen , Zhihang Hu , Siqi Sun , Qingxiong Tan , Yixuan Wang , Qinze Yu , Licheng Zong , Liang Hong , Jin Xiao , Tao Shen , Irwin King , Yu Li

Rising costs in recent years of developing new drugs and treatments have led to extensive research in optimization techniques in biomolecular design. Currently, the most widely used approach in biomolecular design is directed evolution,…

Machine Learning · Computer Science 2021-11-09 Alexander Whatley , Zhekun Luo , Xiangru Tang

We propose a method to facilitate exploration and analysis of new large data sets. In particular, we give an unsupervised deep learning approach to learning a latent representation that captures semantic similarity in the data set. The core…

Computer Vision and Pattern Recognition · Computer Science 2020-12-23 Gary B Huang , Huei-Fang Yang , Shin-ya Takemura , Pat Rivlin , Stephen M Plaza

Predicting protein secondary structures such as alpha helices, beta sheets, and coils from amino acid sequences is essential for understanding protein function. This work presents a transformer-based model that applies attention mechanisms…

Artificial Intelligence · Computer Science 2025-12-10 Manzi Kevin Maxime

To analyze the scaling potential of deep tabular representation learning models, we introduce a novel Transformer-based architecture specifically tailored to tabular data and cross-table representation learning by utilizing table-specific…

Machine Learning · Computer Science 2023-10-02 Maximilian Schambach , Dominique Paul , Johannes S. Otterbach

Unsupervised learning aims at the discovery of hidden structure that drives the observations in the real world. It is essential for success in modern machine learning. Latent variable models are versatile in unsupervised learning and have…

Machine Learning · Computer Science 2016-06-13 Furong Huang

Kernel classifiers and regressors designed for structured data, such as sequences, trees and graphs, have significantly advanced a number of interdisciplinary areas such as computational biology and drug design. Typically, kernels are…

Machine Learning · Computer Science 2020-01-14 Hanjun Dai , Bo Dai , Le Song

Prediction of protein secondary structure from the amino acid sequence is a classical bioinformatics problem. Common methods use feed forward neural networks or SVMs combined with a sliding window, as these models does not naturally handle…

Quantitative Methods · Quantitative Biology 2015-01-06 Søren Kaae Sønderby , Ole Winther

Transformer-based models have demonstrated remarkable in-context learning capabilities, prompting extensive research into its underlying mechanisms. Recent studies have suggested that Transformers can implement first-order optimization…

Machine Learning · Computer Science 2024-03-06 Angeliki Giannou , Liu Yang , Tianhao Wang , Dimitris Papailiopoulos , Jason D. Lee

Recent work in deep learning has opened new possibilities for solving classical algorithmic tasks using end-to-end learned models. In this work, we investigate the fundamental task of solving linear systems, particularly those that are…

Machine Learning · Computer Science 2025-11-19 Pietro Sittoni , Francesco Tudisco

Transformers are state-of-the-art models for a variety of sequence modeling tasks. At their core is an attention function which models pairwise interactions between the inputs at every timestep. While attention is powerful, it does not…

Computation and Language · Computer Science 2021-03-23 Hao Peng , Nikolaos Pappas , Dani Yogatama , Roy Schwartz , Noah A. Smith , Lingpeng Kong

In this paper, we develop a new framework for sensing and recovering structured signals. In contrast to compressive sensing (CS) systems that employ linear measurements, sparse representations, and computationally complex convex/greedy…

Machine Learning · Computer Science 2016-09-01 Ali Mousavi , Ankit B. Patel , Richard G. Baraniuk

While deep learning has revolutionized research and applications in NLP and computer vision, this has not yet been the case for behavioral modeling and behavioral health applications. This is because the domain's datasets are smaller, have…

Machine Learning · Computer Science 2021-07-14 Mike A. Merrill , Tim Althoff

This paper proposes to learn analysis transform network for dynamic magnetic resonance imaging (LANTERN) with small dataset. Integrating the strength of CS-MRI and deep learning, the proposed framework is highlighted in three components:…

Image and Video Processing · Electrical Eng. & Systems 2019-08-27 Shanshan Wang , Yanxia Chen , Taohui Xiao , Ziwen Ke , Qiegen Liu , Hairong Zheng

Deep learning has attracted great attention recently and yielded the state of the art performance in dimension reduction and classification problems. However, it cannot effectively handle the structured output prediction, e.g. sequential…

Machine Learning · Computer Science 2015-05-05 Gang Chen , Ran Xu , Sargur Srihari

Given the broad application of infrared technology across diverse fields, there is an increasing emphasis on investigating super-resolution techniques for infrared images within the realm of deep learning. Despite the impressive results of…

Image and Video Processing · Electrical Eng. & Systems 2024-01-25 Feiwei Qin , Kang Yan , Changmiao Wang , Ruiquan Ge , Yong Peng , Kai Zhang