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Quantum heuristics have shown promise in solving various optimization problems, including lattice protein folding. Equally relevant is the inverse problem, protein design, where one seeks sequences that fold to a given target structure. The…

We present a fault-tolerant semi-global control strategy for universal quantum computers. We show that N-dimensional array of qubits where only (N-1)-dimensional addressing resolution is available is compatible with fault-tolerant universal…

Quantum Physics · Physics 2010-08-11 G. A. Paz-Silva , G. K. Brennen , J. Twamley

The quantum approximate optimization algorithm (QAOA) is a hybrid quantum-classical variational algorithm that offers the potential to handle combinatorial optimization problems. Introducing constraints in such combinatorial optimization…

Quantum Physics · Physics 2021-12-15 Santosh Kumar Radha

We developed a quantum eigensolver (QE) which is based on an extension of optimized binary configurations measured by quantum annealing (QA) on a D-Wave Quantum Annealer (D-Wave QA). This approach performs iterative QA measurements to…

Quantum Physics · Physics 2024-06-06 Hayun Park , Hunpyo Lee

Variational quantum eigensolver (VQE) is an efficient computational method promising chemical accuracy in electronic structure calculations on a universal-gate quantum computer. However, such a simple task as computing the electronic energy…

Chemical Physics · Physics 2018-06-04 Ilya G. Ryabinkin , Scott N. Genin , Artur F. Izmaylov

A major challenge in quantum computing is its application to large real-world datasets due to scarce quantum hardware resources. One approach to enabling tractable quantum models for such datasets involves finding low-dimensional…

Quantum Physics · Physics 2025-04-11 Gaoyuan Wang , Jonathan Warrell , Prashant S. Emani , Mark Gerstein

The recent emergence of novel computational devices, such as quantum computers, coherent Ising machines, and digital annealers presents new opportunities for hardware-accelerated hybrid optimization algorithms. Unfortunately, demonstrations…

Optimization and Control · Mathematics 2020-10-21 Yuchen Pang , Carleton Coffrin , Andrey Y. Lokhov , Marc Vuffray

This report offers a comprehensive analysis of the evolving landscape of quantum algorithm software specifically tailored for condensed matter physics. It examines fundamental quantum algorithms such as Variational Quantum Eigensolver…

Strongly Correlated Electrons · Physics 2025-06-19 T. Farajollahpour

Quantum computers are expected to provide a ultimate solver for quantum many-body systems, although it is a tremendous challenge to achieve that goal on current noisy quantum devices. This work illustrated quantum simulations of ab initio…

Nuclear Theory · Physics 2026-01-05 Chongji Jiang , Junchen Pei , Rongzhe Hu , Shaoliang Jin , Haoyu Shang , Siqin Fan , Furong Xu

Efficient characterization of highly entangled multi-particle systems is an outstanding challenge in quantum science. Recent developments have shown that a modest number of randomized measurements suffices to learn many properties of a…

Quantum Physics · Physics 2022-12-13 Katherine Van Kirk , Jordan Cotler , Hsin-Yuan Huang , Mikhail D. Lukin

Quantum computing holds the promise of solving classically intractable problems. Enabling this requires scalable and hardware-efficient quantum processors with vanishing error rates. This perspective manuscript describes how bosonic codes,…

Mixed discrete-continuous optimization is central to engineering design, where discrete choices interact with continuous fields. These problems are difficult due to high-dimensional, complex search spaces. To tackle them, Quantum Annealing…

Computational Engineering, Finance, and Science · Computer Science 2026-03-19 Fabian Key , Lukas Freinberger , Mayu Muramatsu , Norbert Hosters

The investigation of strongly-correlated quantum matter is difficult due to the curse of dimensionality and intricate entanglement structures. These challenges are particularly pronounced in the vicinity of continuous quantum phase…

Quantum Physics · Physics 2025-08-26 Qiang Miao , Tianyi Wang , Kenneth R. Brown , Thomas Barthel , Marko Cetina

Being a numerically exact method for the simulation of dynamics in open quantum systems, the hierarchical equations of motion (HEOM) still suffers from the curse of dimensionality. In this study, we propose a novel MCE-HEOM method, which…

Chemical Physics · Physics 2025-09-08 Zhecun Shi , Huiqiang Zhou , Lei Huang , Rixin Xie , Linjun Wang

Quantum computing is an important developing technology with the potential to revolutionise the landscape of scientific and business problems that can be practically addressed. The widespread excitement derives from the potential for a…

Quantum Physics · Physics 2022-11-24 R. Cumming , T. Thomas

We introduce multiple parametrized circuit ans\"atze and present the results of a numerical study comparing their performance with a standard Quantum Alternating Operator Ansatz approach. The ans\"atze are inspired by mixing and phase…

Quantum Physics · Physics 2023-01-27 Ryan LaRose , Eleanor Rieffel , Davide Venturelli

The Variational Quantum Eigensolver (VQE) is one the most perspective algorithms for simulation of quantum many body physics that have recently attached a lot of attention and believed would be practical for implementation on the near term…

Quantum Physics · Physics 2021-05-03 Belozerova Polina , Shangareev Arthur , Zotov Yuriy , Yung Manhong , lv Dingshun

Quantum computers promise to efficiently solve important problems that are intractable on a conventional computer. For quantum systems, where the dimension of the problem space grows exponentially, finding the eigenvalues of certain…

Combinatorial optimization is a promising application for near-term quantum computers, however, identifying performant algorithms suited to noisy quantum hardware remains as an important goal to potentially realizing quantum computational…

Quantum Physics · Physics 2025-04-01 Titus D. Morris , Ananth Kaushik , Martin Roetteler , Phillip C. Lotshaw

Scaling the size of monolithic quantum computer systems is a difficult task. As the number of qubits within a device increases, a number of factors contribute to decreases in yield and performance. To meet this challenge, distributed…

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