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To successfully execute large-scale algorithms, a quantum computer will need to perform its elementary operations near perfectly. This is a fundamental challenge since all physical qubits suffer a considerable level of noise. Moreover, real…

Quantum Physics · Physics 2023-06-29 Armands Strikis , Simon C. Benjamin , Benjamin J. Brown

Thermodynamics is a highly successful macroscopic theory widely used across the natural sciences and for the construction of everyday devices, from car engines and fridges to power plants and solar cells. With thermodynamics predating…

Quantum Physics · Physics 2016-04-07 Philipp Kammerlander , Janet Anders

AlphaFold has achieved groundbreaking advancements in protein structure prediction, exerting profound influence across biology, medicine, and drug discovery. However, its reliance on multiple sequence alignment (MSA) is inherently…

Quantum Physics · Physics 2025-06-03 Rong Chen , Quan-Xin Mei , Wen-Ding Zhao , Lin Yao , Hao-Xiang Yang , Shun-Yao Zhang , Jiao Chen , Hong-Lin Li

Here we explore which heuristic quantum algorithms for combinatorial optimization might be most practical to try out on a small fault-tolerant quantum computer. We compile circuits for several variants of quantum accelerated simulated…

Quantum annealers (QA), such as D-Wave systems, become increasingly efficient and competitive at solving combinatorial optimization problems. However, solving problems that do not directly map the chip topology remains challenging for this…

Quantum Physics · Physics 2024-07-30 Valentin Gilbert , Stéphane Louise

Recent progress on concatenated codes, especially many-hypercube codes, achieves unprecedented space efficiency. Yet two critical challenges persist in practice. First, these codes lack efficient implementations of addressable logical…

Hardware Architecture · Computer Science 2025-08-11 Pengyu Liu , Mingkuan Xu , Hengyun Zhou , Hanrui Wang , Umut A. Acar , Yunong Shi

The task of Multiple Sequence Alignment (MSA) is a constrained combinatorial optimization problem that is generally considered a complex computational problem. In this paper, we first present a binary encoding of MSA and devise a…

Hard combinatorial optimization problems, often mapped to Ising models, promise potential solutions with quantum advantage but are constrained by limited qubit counts in near-term devices. We present an innovative quantum-inspired framework…

Quantum Physics · Physics 2024-12-25 Co Tran , Quoc-Bao Tran , Hy Truong Son , Thang N Dinh

A quantum annealer heuristically minimizes quadratic unconstrained binary optimization (QUBO) problems, but is limited by the physical hardware in the size and density of the problems it can handle. We have developed a meta-heuristic solver…

Discrete Mathematics · Computer Science 2016-05-20 Gili Rosenberg , Mohammad Vazifeh , Brad Woods , Eldad Haber

We propose a framework to solve non-linear and history-dependent mechanical problems based on a hybrid classical computer -- quantum annealer approach. Quantum Computers are anticipated to solve particular operations exponentially faster.…

Computational Engineering, Finance, and Science · Computer Science 2024-02-20 Van-Dung Nguyen , Ling Wu , Françoise Remacle , Ludovic Noels

The design of a scalable Quantum Control Architecture (QCA) faces two primary challenges. First, the continuous growth in qubit counts has rendered distributed QCA inevitable, yet the nondeterministic latencies inherent in feedback loops…

Quantum computing is expected to transform a range of computational tasks beyond the reach of classical algorithms. In this work, we examine the application of variational quantum algorithms (VQAs) for unsupervised image segmentation to…

Computer Vision and Pattern Recognition · Computer Science 2025-01-29 Supreeth Mysore Venkatesh , Antonio Macaluso , Marlon Nuske , Matthias Klusch , Andreas Dengel

Optimization problems are ubiquitous in various industrial settings, and multi-knapsack optimization is one recurrent task faced daily by several industries. The advent of quantum computing has opened a new paradigm for computationally…

Variational quantum eigensolver (VQE) solves the ground state problem of a given Hamiltonian by finding the parameters of a quantum circuit ansatz that minimizes the Hamiltonian expectation value. Among possible quantum circuit ans\"{a}tze,…

Quantum Physics · Physics 2024-01-31 Chae-Yeun Park

Optimizing Reconfigurable Intelligent Surfaces (RIS) is a high-dimensional combinatorial challenge. Current quantum algorithms often simplify this problem by ignoring physical constraints like mutual coupling, which significantly degrades…

Computational Engineering, Finance, and Science · Computer Science 2026-05-08 Marco Pasquale , Erik M. Åsgrim , Stefano Markidis , Oscar Quevedo-Teruel

Quantum computing has brought a paradigm change in computer science, where non-classical technologies have promised to outperform their classical counterpart. Such an advantage was only demonstrated for tasks without practical applications,…

Variational quantum algorithms exploit the features of superposition and entanglement to optimize a cost function efficiently by manipulating the quantum states. They are suitable for noisy intermediate-scale quantum (NISQ) computers that…

Quantum Physics · Physics 2023-08-29 Yunya Liu , Jiakun Liu , Jordan R. Raney , Pai Wang

In this paper, the Quantum Approximate Optimization Algorithm (QAOA) is analyzed by leveraging symmetries inherent in problem Hamiltonians. We focus on the generalized formulation of optimization problems defined on the sets of $n$-element…

Quantum Physics · Physics 2024-01-23 Boris Tsvelikhovskiy , Ilya Safro , Yuri Alexeev

The recent advent of commercially available quantum annealing hardware (QAH) has expanded opportunities for research into quantum annealing-based algorithms. In the domain of power systems, this advancement has driven increased interest in…

Optimization and Control · Mathematics 2025-03-26 Rosemary Barrass , Harsha Nagarajan , Carleton Coffrin