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We establish an existence result for weak solutions to an aggregation-diffusion-reaction equation with a constraint, arising in the modelling of multiple sclerosis. The model is derived from a general chemotaxis-type framework and describes…

Analysis of PDEs · Mathematics 2026-01-28 S. Fagioli , M. Kamath Katapady

We consider a system of reaction-diffusion equations including chemotaxis terms and coming out of the modeling of multiple sclerosis. The global existence of strong solutions to this system in any dimension is proved, and it is also shown…

Analysis of PDEs · Mathematics 2020-09-29 Laurent Desvillettes , Valeria Giunta , Jeff Morgan , Bao Quoc Tang

Multiple Sclerosis is a chronic autoimmune disorder characterized by the degradation of the myelin sheath in the central nervous system, leading to neurological impairments. In this work, we analyze a reaction-diffusion model derived from…

Tissues and Organs · Quantitative Biology 2026-03-10 Romina Travaglini , Rossella Della Marca

In this paper, a class of reaction-diffusion equations for Multiple Sclerosis is presented. These models are derived by means of a diffusive limit starting from a proper kinetic description, taking account of the underlying microscopic…

Quantitative Methods · Quantitative Biology 2026-01-07 Marzia Bisi , Maria Groppi , Giorgio Martalò , Romina Travaglini

We study a cross-diffusion model for tissue regeneration which involves the dynamics of human mesenchymal stem cells interacting with chondrocytes in a medium containing a differentiation factor. The latter acts as a chemoattractant for the…

Analysis of PDEs · Mathematics 2025-11-04 Nishith Mohan , Christina Surulescu

We consider a one-dimensional version of a model obtained in [C. Engwer, A. Hunt, and C. Surulescu: Effective equations for anisotropic glioma spread with proliferation: a multiscale approach and comparisons with previous settings, IMA J.…

Analysis of PDEs · Mathematics 2025-11-04 Michael Winkler , Christina Surulescu

We consider a degenerate quasilinear chemotaxis--Stokes type involving rotation in the aggregative term, \begin{equation} \left\{ \begin{array}{l} n_t+u\cdot\nabla n=\Delta n^m-\nabla\cdot(nS(x,n,c)\cdot\nabla c),\quad x\in \Omega, t>0,…

Analysis of PDEs · Mathematics 2017-01-06 Jiashan Zheng

In this paper, we study an optimal control problem for a coupled non-linear system of reaction-diffusion equations with degenerate diffusion, consisting of two partial differential equations representing the density of cells and the…

Optimization and Control · Mathematics 2024-07-11 Georges Chamoun , Mazen Saad , Toni Sayah , Sarah Serhal

We consider a chemotaxis-fluid system involving nonlinear cell diffusion of porous medium type, signal consumption by cells, and rather general, possibly matrix-valued, chemotactic sensitivities. It is shown that if the corresponding…

Analysis of PDEs · Mathematics 2015-01-29 Michael Winkler

This paper considers the chemotaxis-Navier--Stokes system with nonlinear diffusion and logistic-type degradation term \begin{align*} \begin{cases} n_t + u\cdot\nabla n = \nabla \cdot(D(n)\nabla n) - \nabla\cdot(n \chi(c) \nabla c) + \kappa…

Analysis of PDEs · Mathematics 2019-03-27 Masaaki Mizukami

A mathematical model for the discrete nonlinear fragmentation (collision-induced breakage) equation with diffusion is studied. The existence of global weak solutions is established in arbitrary spatial dimensions without assuming a strictly…

Analysis of PDEs · Mathematics 2026-03-12 Saumyajit Das , Ram Gopal Jaiswal

This paper addresses the existence and regularity of weak solutions for a fully parabolic model of chemotaxis, with prevention of overcrowding, that degenerates in a two-sided fashion, including an extra nonlinearity represented by a…

Analysis of PDEs · Mathematics 2015-05-13 Mostafa Bendahmane , Raimund Brger , Ricardo Ruiz Baier , José Miguel Urbano

This paper is devoted to the analysis of non-negative solutions for a degenerate parabolic-elliptic Patlak-Keller-Segel system with critical nonlinear diffusion in a bounded domain with homogeneous Neumann boundary conditions. Our aim is to…

Analysis of PDEs · Mathematics 2012-07-19 Elissar Nasreddine

We consider the chemotaxis-fluid system \begin{align}\label{star}\tag{$\diamondsuit$} \left\{ \begin{array}{r@{\,}c@{\,}c@{\ }l@{\quad}l@{\quad}l@{\,}c} n_{t}&+&u\cdot\!\nabla n&=\Delta n^m-\nabla\!\cdot(n\nabla c),\ &x\in\Omega,& t>0,\\…

Analysis of PDEs · Mathematics 2018-08-06 Tobias Black

We analyze the mathematical properties of a multi-species biofilm cross-diffusion model together with very general reaction terms and mixed Dirichlet-Neumann boundary conditions on a bounded domain. This model belongs to the class of…

Analysis of PDEs · Mathematics 2018-05-08 Esther S. Daus , Josipa-Pina Milišić , Nicola Zamponi

We present a mathematical study for the development of Multiple Sclerosis in which a spatio-temporal kinetic { theory} model describes, at the mesoscopic level, the dynamics of a high number of interacting agents. We consider both…

Analysis of PDEs · Mathematics 2026-01-07 Romina Travaglini , João Miguel Oliveira

In this paper, we derive a new chemotaxis model with degenerate diffusion and density-dependent chemotactic sensitivity, and we provide a more realistic description of cell migration process for its early and late stages. Different from the…

Analysis of PDEs · Mathematics 2023-07-19 Tianyuan Xu , Shanming Ji , Chunhua Jin , Ming Mei , Jingxue Yin

We study a quasilinear chemotaxis system of singular type, where the diffusion operator is given by $\Delta u^m$ with $0<m<1$, corresponding to the fast diffusion regime, and where the chemotactic drift is nonlinear. Since H\"older…

Analysis of PDEs · Mathematics 2026-04-17 M. Marras , F. Ragnedda , S. Vernier-Piro , V. Vespri

Global existence of very weak solutions to a non-local diffusion-advection-reaction equation is established under no-flux boundary conditions in higher dimensions. The equation features degenerate myopic diffusion and nonlocal adhesion and…

Analysis of PDEs · Mathematics 2024-10-18 Maria Eckardt , Anna Zhigun

This paper aims at providing a first step toward a qualitative theory for a new class of chemotaxis models derived from the celebrated Keller-Segel system, with the main novelty being that diffusion is nonlinear with flux delimiter…

Analysis of PDEs · Mathematics 2016-05-17 Nicola Bellomo , Michael Winkler
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