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Mass campaigns with antimalarial drugs are potentially a powerful tool for local elimination of malaria, yet current diagnostic technologies are insufficiently sensitive to identify all individuals who harbor infections. At the same time,…

Populations and Evolution · Quantitative Biology 2016-02-17 Jaline Gerardin , Caitlin A. Bever , Busiku Hamainza , John M. Miller , Philip A. Eckhoff , Edward A. Wenger

This article is aimed at proposing a generalization of the Ross-Macdonald model for the transmission of Vector-borne diseases in which human-to-human contagions are also considered. We first present this generalized model by formulating a…

An epidemic Susceptible-Vaccinated-Infected-Removed-Susceptible (SVIRS) model is presented on a weighted-undirected network with graph Laplacian diffusion. Disease-free equilibrium always exists while the existence and uniqueness of endemic…

Numerical Analysis · Mathematics 2025-03-25 Madhab Barman , Nachiketa Mishra

During infectious disease outbreaks, estimates of time-varying pathogen transmissibility, such as the instantaneous reproduction number R(t) or epidemic growth rate r(t), are used to inform decision-making by public health authorities. For…

Populations and Evolution · Quantitative Biology 2024-09-30 Cathal Mills , Tarek Alrefae , William S. Hart , Moritz U. G. Kraemer , Kris V. Parag , Robin N. Thompson , Christl A. Donnelly , Ben Lambert

In this paper, we give a complete analysis of an SIS epidemiological model in a population of varying size with two dissimilar groups of infective individuals. It is mainly based on the discussion of the existence and stability of…

Classical Analysis and ODEs · Mathematics 2007-05-23 M. R. Razvan

We study the random times between successive cases in a transmission chain of infectious diseases with asymptomatic carriers. We derive the probability distribution of this generation time (in days) from a discrete-time epidemic model with…

Populations and Evolution · Quantitative Biology 2026-04-16 Jordi Ripoll , Joan Saldaña

Systemic risk measures play a crucial role in analyzing individual losses conditional on extreme system-wide disasters. In this paper, we provide a unified asymptotic treatment for systemic risk measures. First, we classify them into two…

Risk Management · Quantitative Finance 2026-05-26 Bingzhen Geng , Yang Liu , Yimiao Zhao

Tracking the spread of infectious disease during a pandemic has posed a great challenge to the governments and health sectors on a global scale. To facilitate informed public health decision-making, the concerned parties usually rely on…

Methodology · Statistics 2023-06-05 Tejasv Bedi , Yanxun Xu , Qiwei Li

Modelling epidemics via classical population-based models suffers from shortcomings that so-called individual-based models are able to overcome, as they are able to take heterogeneity features into account, such as super-spreaders, and…

Optimization and Control · Mathematics 2022-05-16 C. Courtès , E. Franck , K. Lutz , L. Navoret , Y. Privat

This work introduces a novel epidemiological model that simultaneously considers multiple viral strains, reinfections due to waning immunity response over time and an optimal control formulation. This enables us to derive optimal mitigation…

Systems and Control · Electrical Eng. & Systems 2021-09-10 Edilson F. Arruda , Dayse H. Pastore , Clauda M. Dias , Shyam S. Das

The focus of this article is on the dynamics of a new susceptible-infected model which consists of a susceptible group ($S$) and two different infectious groups ($I_1$ and $I_2$). Once infected, an individual becomes a member of one of…

Populations and Evolution · Quantitative Biology 2020-06-01 Ayse Peker-Dobie , Semra Ahmetolan , Ayse Humeyra Bilge , Ali Demirci

We study a multi-type SIR epidemic process among a heterogeneous population that interacts through a network. When we base social contact on a random graph with given vertex degrees, we give limit theorems on the fraction of infected…

Physics and Society · Physics 2021-11-02 Hamed Amini , Andreea Minca

Our study is devoted to a four-compartment epidemic model of a constant population of independent random walkers. Each walker is in one of four compartments (S-susceptible, C-infected but not infectious (period of incubation), I-infected…

Populations and Evolution · Quantitative Biology 2023-08-29 Teo Granger , Thomas Michelitsch , Bernard Collet , Michael Bestehorn , Alejandro Riascos

Imbalanced classification remains a pervasive challenge in machine learning, particularly when minority samples are too scarce to provide a robust discriminative boundary. In such extreme scenarios, conventional models often suffer from…

Machine Learning · Computer Science 2026-04-29 Hongfei Wu , Ruijian Han , Yancheng Yuan

We propose a variational autoencoder (VAE) approach for parameter estimation in nonlinear mixed-effects models based on ordinary differential equations (NLME-ODEs) using longitudinal data from multiple subjects. In moderate dimensions,…

Methodology · Statistics 2026-02-11 Zhe Li , Mélanie Prague , Rodolphe Thiébaut , Quentin Clairon

In the following short article we adapt a new and popular machine learning model for inference on medical data sets. Our method is based on the Variational AutoEncoder (VAE) framework that we adapt to survival analysis on small data sets…

Machine Learning · Statistics 2018-12-06 Cédric Beaulac , Jeffrey S. Rosenthal , David Hodgson

Public health services are constantly searching for new ways to reduce the spread of infectious diseases, such as public vaccination of asymptomatic individuals, quarantine (isolation) and treatment of symptomatic individuals. Epidemic…

Populations and Evolution · Quantitative Biology 2018-06-11 Shanshan Chen , Michael Small , Xinchu Fu

Flavescence dor\'ee (FD) is a disease of grapevine transmitted by an insect vector, $Scaphoideus$ $titanus$ Ball. At present, no prophylaxis exists, so mandatory control procedures (e.g. removal of infected plants, and insecticidal sprays…

Populations and Evolution · Quantitative Biology 2014-07-16 Federico Lessio , Alessandro Portaluri , Francesco Paparella , Alberto Alma

We develop a multi-patch and multi-group model that captures the dynamics of an infectious disease when the host is structured into an arbitrary number of groups and interacts into an arbitrary number of patches where the infection takes…

Populations and Evolution · Quantitative Biology 2017-11-23 Derdei Bichara , Abderrahman Iggidr

Community involvement and the preventive behavior of households are considered to be at the heart of vector-control strategies. In this work, we consider a simple theoretical model that enables us to take into account human behaviors that…

Dynamical Systems · Mathematics 2016-11-17 Y. Dumont , J. Thuilliez