Related papers: Streamlined Pin-Ridge-Filter Design for Single-ene…
Purpose: To evaluate automated multicriteria optimization (MCO)-- designed for intensity modulated radiation therapy (IMRT), but invoked with limited segmentation -- to efficiently produce high quality 3D conformal treatment (3D-CRT) plans.…
The advent of ultra-high dose rate irradiation, known as FLASH radiation therapy, has shown promising potential in reducing toxicity while maintaining tumor control. However, the clinical translation of these benefits necessitates efficient…
Objective: While FLASH radiotherapy is recognized for short-term normal tissue sparing, its durability in late-responding organs remains uncertain, limiting clinical adoption. With its clinical importance and steep dose-response, the spinal…
Integrated microwave photonic filters (IMPFs) emerge as promising candidates for advanced microwave systems owing to their distinctive combination of wide operational bandwidth, flexibility, and compact size. Nevertheless, the complex and…
Background and Objective: Recent experimental studies using ultra-high dose rate radiation therapy (FLASH-RT) have shown improved normal tissue sparing and comparable tumor control compared to conventional dose rate RT. Pencil beam scanning…
Purpose: Pencil beam scanning proton therapy is sensitive to respiratory motion, leading to potential dose inhomogeneities due to interplay effects. We developed and validated a predictive framework to assess interplay and motion robustness…
Geometric uncertainty can degrade treatment quality in radiation therapy. While margins and robust optimization mitigate these effects, they provide only implicit control over clinical goal fulfillment probability. We therefore develop a…
High peak-to-average power ratio (PAPR) is one of the main factors limiting cell coverage for cellular systems, especially in the uplink direction. Discrete Fourier transform spread orthogonal frequency-domain multiplexing (DFT-s-OFDM) with…
Optimal Power Flow (OPF) is an important tool used to coordinate assets in electric power systems to ensure customer voltages are within pre-defined tolerances and to improve distribution system operations. While convex relaxations of…
Recently, shoot-through proton FLASH has been proposed where the highest energy is extracted from the cyclotron to maximize the dose rate (DR). Even though our proton pencil beam scanning system can deliver 250 MeV (the highest energy), it…
The optimal selection, sizing, and location of small-scale technologies within a grid-connected distributed energy system (DES) can contribute to reducing carbon emissions, consumer costs, and network imbalances. This is the first study to…
The use of asynchronous design approaches to construct digital signal processing (DSP) systems is a rapidly growing research area driven by a wide range of emerging energy constrained applications such as wireless sensor network, portable…
Verification of patient specific proton stopping powers obtained in the patient treatment position can be used to reduce the distal margins needed in particle beam planning. Proton radiography can be used as a pre-treatment instrument to…
Purpose: To improve target coverage and reduce the dose in the surrounding organs-at-risks (OARs), we developed an image-guided treatment method based on a precomputed library of treatment plans controlled and delivered in real-time.…
Robust optimization is a commonly employed method to mitigate uncertainties in the planning of intensity-modulated proton therapy (IMPT). In certain contexts, the large number of uncertainty scenarios makes the robust problem impractically…
Objective: This study aims to investigate the influence of organ architecture (specifically the distinction between serial and parallel tissue) on the protective FLASH effect when organs are irradiated with inhomogeneous dose distributions.…
Treatment planning uncertainties are typically managed using margin-based or robust optimization. Margin-based methods expand the clinical target volume (CTV) to a planning target volume, generally unsuited for proton therapy. Robust…
Background: Ultra-high dose rate proton therapy shows promise in tissue sparing by enhancing therapeutic ratio through the FLASH effect. In radiotherapy, accurate in vivo dosimetry is crucial for quality assurance, but remains challenging…
Purpose: To demonstrate the feasibility of fast Monte Carlo (MC) based inverse biological planning for the treatment of head and neck tumors in spot-scanning proton therapy. Methods: Recently, a fast and accurate Graphics Processor Unit…
Background: FLASH radiotherapy is a treatment regime that delivers therapeutic dose to tumors at an ultra-high dose rate while maintaining adequate normal tissue sparing. However, a comprehensive understanding of the underlying mechanisms,…