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The human proteome is enriched in proteins that do not fold into a stable 3D structure. These intrinsically disordered proteins (IDPs) spontaneously fluctuate between a large number of configurations in their native form. Remarkably, the…

Myopia in human and animals is caused by the axial elongation of the eye and is closely linked to the thinning of the sclera which supports the eye tissue. This thinning has been correlated with the overproduction of matrix…

Systems and Control · Computer Science 2013-09-05 Qin Shu , Diana Catalina Ardila , Ricardo G. Sanfelice , Jonathan P. Vande Geest

The evolution of complex cellular life involved two major transitions: the encapsulation of self-replicating genetic entities into cellular units and the aggregation of individual genes into a collectively replicating genome. In this paper,…

Populations and Evolution · Quantitative Biology 2021-09-21 Daniel B. Cooney , Fernando W. Rossine , Dylan H. Morris , Simon A. Levin

Retinal fundus photography enhancement is important for diagnosing and monitoring retinal diseases. However, early approaches to retinal image enhancement, such as those based on Generative Adversarial Networks (GANs), often struggle to…

Image and Video Processing · Electrical Eng. & Systems 2024-11-05 Xuanzhao Dong , Wenhui Zhu , Xin Li , Guoxin Sun , Yi Su , Oana M. Dumitrascu , Yalin Wang

Biological systems transduce signals from their surroundings in numerous ways. This paper introduces a communication system using the light-gated ion channel Channelrhodopsin-2 (ChR2), which causes an ion current to flow in response to…

Information Theory · Computer Science 2024-11-11 Taha Sajjad , Andrew W. Eckford

Stem cells can precisely and robustly undergo cellular differentiation and lineage commitment, referred to as stemness. However, how the gene network underlying stemness regulation reliably specifies cell fates is not well understood. To…

Molecular Networks · Quantitative Biology 2020-04-02 Bin Huang , Mingyang Lu , Madeline Galbraith , Herbert Levine , Jose N. Onuchic , Dongya Jia

Ranaspumin-2 (Rsn-2) is a surfactant protein found in the foam nests of the t\'{u}ngara frog. Previous experimental work has led to a proposed model of adsorption which involves an unusual clam shell-like `unhinging' of the protein at an…

Biomolecules · Quantitative Biology 2016-08-30 Ryan J. Morris , Giovanni B. Brandani , Vibhuti Desai , Brian O. Smith , Marieke Schor , Cait E. MacPhee

Fundus image quality is crucial for diagnosing eye diseases, but real-world conditions often result in blurred or unreadable images, increasing diagnostic uncertainty. To address these challenges, this study proposes RetinaRegen, a hybrid…

Image and Video Processing · Electrical Eng. & Systems 2025-02-28 Yuhan Tang , Yudian Wang , Weizhen Li , Ye Yue , Chengchang Pan , Honggang Qi

Most types of retinal neurons are spatially positioned in non-random patterns, termed retinal mosaics. Several developmental mechanisms are thought to be important in the formation of these mosaics. Most evidence to date suggests that…

Neurons and Cognition · Quantitative Biology 2012-08-07 Stephen J. Eglen , James C. T. Wong

The on-off phenomena of opponent colors in center-surround may be the best-known facts of retinal processing of information. Apparently, however, no explicit model has been proposed that shows how neurons can be connected to produce the…

Neurons and Cognition · Quantitative Biology 2025-02-07 Lane Yoder

Diffractive optical neural networks (DONNs) have demonstrated unparalleled energy efficiency and parallelism by processing information directly in the optical domain. However, their computational expressivity is constrained by static,…

Optics · Physics 2026-03-11 Ziang Yin , Qi Jing , Raktim Sarma , Rena Huang , Yu Yao , Jiaqi Gu

The paper theoretically establishes and studies the sub-Doppler linear optical Ramsey resonances that arise under certain conditions near centers of optical transitions in the absorption of a sufficiently weak monochromatic light beam…

Atomic Physics · Physics 2025-06-04 Azad Ch. Izmailov

The process of polymerizing a protein by a ribosome, using a messenger RNA (mRNA) as the corresponding template, is called {\it translation}. Ribosome may be regarded as a molecular motor for which the mRNA template serves also as the…

Biological Physics · Physics 2015-03-19 Ajeet K. Sharma , Debashish Chowdhury

Genomes evolve as modules. In prokaryotes (and some eukaryotes), genetic material can be transferred between species and integrated into the genome via homologous or illegitimate recombination. There is little reason to imagine that the…

Genomics · Quantitative Biology 2008-01-29 Cheong Xin Chan , Robert G. Beiko , Aaron E. Darling , Mark A. Ragan

A major part of membrane function is conducted by proteins, both integral and peripheral. Peripheral membrane proteins temporarily adhere to biological membranes, either to the lipid bilayer or to integral membrane proteins with…

Biomolecules · Quantitative Biology 2014-06-27 Katerina C. Nastou , Georgios N. Tsaousis , Kimon E. Kremizas , Zoi I. Litou , Stavros J. Hamodrakas

Gene expression programming, a genotype/phenotype genetic algorithm (linear and ramified), is presented here for the first time as a new technique for the creation of computer programs. Gene expression programming uses character linear…

Artificial Intelligence · Computer Science 2007-05-23 Candida Ferreira

Central to the functioning of a living cell is its ability to control the readout or expression of information encoded in the genome. In many cases, a single transcription factor protein activates or represses the expression of many genes.…

Molecular Networks · Quantitative Biology 2013-05-29 Aleksandra M. Walczak , Gapser Tkacik , William Bialek

Rubrene, a superstar in organic semiconductors, has achieved unprecedented achievements in the application of electronic devices, and research based on its various photoelectric properties is still in progress. In this review, we introduced…

Applied Physics · Physics 2020-09-25 Si Liu , Hongnan Wu , Xiaotao Zhang , Wenping Hu

Because of their large size and widespread mechanosensitive interactions the only recently discovered titled transmembrane proteins have attracted much attention. Here we present and discuss their hydropathic profiles using a new method of…

Other Quantitative Biology · Quantitative Biology 2023-01-02 J. C. Phillips

We present optical absorption spectra of mixed films of pentacene (PEN) and perfluoropentacene (PFP) grown on SiO2. We investigated the influence of intermolecular coupling between PEN and PFP on the optical spectra by analyzing samples…

Materials Science · Physics 2011-06-22 K. Broch , U. Heinemeyer , A. Hinderhofer , F. Anger , R. Scholz , A. Gerlach , F. Schreiber