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Proteins are complex biomolecules that play a central role in various biological processes, making them critical targets for breakthroughs in molecular biology, medical research, and drug discovery. Deciphering their intricate, hierarchical…

Machine Learning · Computer Science 2025-05-09 Viet Thanh Duy Nguyen , Truong-Son Hy

Ophthalmic images may contain identical-looking pathologies that can cause failure in automated techniques to distinguish different retinal degenerative diseases. Additionally, reliance on large annotated datasets and lack of knowledge…

Image and Video Processing · Electrical Eng. & Systems 2022-08-02 Sharif Amit Kamran , Khondker Fariha Hossain , Alireza Tavakkoli , Stewart Lee Zuckerbrod , Salah A. Baker

Nonreciprocal optical devices are key components in photonic integrated circuits for light reflection blocking and routing. Most reported silicon integrated nonreciprocal optical devices to date were unit devices. To allow complex signal…

Self-organized criticality (SOC) is a popular concept that has been the subject of more than 3000 articles in the last 25 years. Here we show that SOC may enable theory to connect standard Web-based (BLAST) short-range amino acid (aa)…

Soft Condensed Matter · Physics 2011-02-14 J. C. Phillips

mRNA translation is a crucial process that leads to protein synthesis in living cells. Therefore, it is a process that needs to work optimally for a cell to stay healthy and alive. With advancements in microscopy and novel experimental…

Subcellular Processes · Quantitative Biology 2023-12-20 Binil Shyam T , Rati Sharma

Retinopathy of prematurity (ROP) is an abnormal blood vessel development in the retina of a prematurely-born infant or an infant with low birth weight. ROP is one of the leading causes for infant blindness globally. Early detection of ROP…

Image and Video Processing · Electrical Eng. & Systems 2020-06-15 Xin Guo , Yusuke Kikuchi , Guan Wang , Jinglin Yi , Qiong Zou , Rui Zhou

Brain function results from communication between neurons connected by complex synaptic networks. Synapses are themselves highly complex and diverse signaling machines, containing protein products of hundreds of different genes, some in…

Computer Vision and Pattern Recognition · Computer Science 2017-07-05 Anish K. Simhal , Cecilia Aguerrebere , Forrest Collman , Joshua T. Vogelstein , Kristina D. Micheva , Richard J. Weinberg , Stephen J. Smith , Guillermo Sapiro

Magombedze and Mulder in 2013 studied the gene regulatory system of Mycobacterium Tuberculosis (Mtb) by partitioning this into three subsystems based on putative gene function and role in dormancy/latency development. Each subsystem, in the…

Molecular Networks · Quantitative Biology 2020-01-22 Honeylou F. Farinas , Eduardo R. Mendoza , Angelyn R. Lao

Tautomerization is a fast chemical reaction where structures of the reactants differ only in the position of a proton and a double bond. Tautomerization often occurs in natural substances and is a fundamental process in organic- and…

The internal image of the proton is unveiled by examining the generalized parton distributions (GPDs) at zero skewness, within the basis light-front quantized environment. Several distributions emerge when a quark is sampled with different…

High Energy Physics - Phenomenology · Physics 2024-01-23 Satvir Kaur , Siqi Xu , Chandan Mondal , Xingbo Zhao , James P. Vary

Optical spin textures with nontrivial topology hold promise for structured light and photonic information processing, yet their generation typically relies heavily on externally structured light with care. This raises questions about their…

Optics · Physics 2026-02-23 Di Liu , Han Liu , Zheng Xi

In this paper I review the submission to the Explaining the Human Visual Brain Challenge 2019 in both the fMRI and MEG tracks. The goal was to construct neural network features which generate the so-called representational dissimilarity…

Neurons and Cognition · Quantitative Biology 2019-07-02 Romuald A. Janik

Myopia is a manifestation of visual impairment caused by an excessively elongated eyeball. Image data is critical material for studying high myopia and pathological myopia. Measurements of spherical equivalent and axial length are the gold…

Computer Vision and Pattern Recognition · Computer Science 2023-12-13 Xiao Ma , Zetian Zhang , Zexuan Ji , Kun Huang , Na Su , Songtao Yuan , Qiang Chen

Proteins, by virtue of their central role in most biological processes, represent one of the key subjects of the study of molecular evolution. Inherent to the indispensability of proteins for living cells is the fact that a given protein…

Biomolecules · Quantitative Biology 2007-05-23 Eric J. Deeds , Eugene I. Shakhnovich

Retinal vessel segmentation is a fundamental step in screening, diagnosis, and treatment of various cardiovascular and ophthalmic diseases. Robustness is one of the most critical requirements for practical utilization, since the test images…

Image and Video Processing · Electrical Eng. & Systems 2021-09-29 Xu Sun , Huihui Fang , Yehui Yang , Dongwei Zhu , Lei Wang , Junwei Liu , Yanwu Xu

Cell membranes separate the cell interior from the external environment. They are constituted by a variety of lipids; their composition determines the dynamics of membrane proteins and affects the ability of the cells to adapt. Even though…

Quantitative Methods · Quantitative Biology 2018-10-04 Nicola Galvanetto

Recent experimental reports on in-plane proton conduction in reduced graphene oxide (rGO) films open a new way for the design of proton exchange membrane essential in fuel cells and chemical filters. At high humidity condition, water…

Materials Science · Physics 2018-09-19 Gum-Chol Ri , Jin-Song Kim , Chol-Jun Yu

We predict and experimentally verify an entoptic phenomenon through which humans are able to perceive and discriminate structured light with space-varying polarization. Direct perception and discrimination is possible through the…

Optics · Physics 2022-05-25 D. Sarenac , C. Kapahi , A. E. Silva , D. G. Cory , B. Thompson , D. A. Pushin

The interaction between Ribonucleic Acids (RNAs) and proteins, also called RNA Protein Interaction (RPI), plays an important role in the life activities of organisms, including in various regulatory processes, such as gene splicing, gene…

Quantitative Methods · Quantitative Biology 2024-10-02 Danyu Li , Rubing Huang , Chenhui Cui , Dave Towey , Ling Zhou , Jinyu Tian , Bin Zou

While most processes in biology are highly deterministic, stochastic mechanisms are sometimes used to increase cellular diversity, such as in the specification of sensory receptors. In the human and Drosophila eye, photoreceptors sensitive…

Cell Behavior · Quantitative Biology 2019-03-06 Haleh Ebadi , Michael Perry , Keith Short , Konstantin Klemm , Claude Desplan , Peter F. Stadler , Anita Mehta