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We propose a novel framework that combines deep generative time series models with decision theory for generating personalized treatment strategies. It leverages historical patient trajectory data to jointly learn the generation of…

Causal inference for observational longitudinal studies often requires the accurate estimation of treatment effects on time-to-event outcomes in the presence of time-dependent patient history and time-dependent covariates. To tackle this…

Machine Learning · Statistics 2022-06-17 Jie Zhu , Blanca Gallego

In this paper we review an approach to estimating the causal effect of a time-varying treatment on time to some event of interest. This approach is designed for the situation where the treatment may have been repeatedly adapted to patient…

Statistics Theory · Mathematics 2007-06-13 J. J. Lok , R. D. Gill , A. W. van der Vaart , J. M. Robins

The widespread adoption of wearable sensors has the potential to provide massive and heterogeneous time series data, driving the use of Artificial Intelligence in human sensing applications. However, data collection remains limited due to…

Machine Learning · Computer Science 2025-12-04 Flavio Di Martino , Franca Delmastro

Recent improvements in conditional generative modeling have made it possible to generate high-quality images from language descriptions alone. We investigate whether these methods can directly address the problem of sequential…

Machine Learning · Computer Science 2023-07-11 Anurag Ajay , Yilun Du , Abhi Gupta , Joshua Tenenbaum , Tommi Jaakkola , Pulkit Agrawal

We analyze the time reversed dynamics of generative diffusion models. If the exact empirical score function is used in a regime of large dimension and exponentially large number of samples, these models are known to undergo transitions…

Statistics Theory · Mathematics 2025-11-17 Anand Jerry George , Rodrigo Veiga , Nicolas Macris

Count data frequently arises in biomedical applications, such as the length of hospital stay. However, their discrete nature poses significant challenges for appropriately modeling conditional quantiles, which are crucial for understanding…

Methodology · Statistics 2025-07-28 Yuta Yamauchi , Genya Kobayashi , Shonosuke Sugasawa

Domain shift, encountered when using a trained model for a new patient population, creates significant challenges for sequential decision making in healthcare since the target domain may be both data-scarce and confounded. In this paper, we…

Machine Learning · Computer Science 2022-03-17 Taylor W. Killian , Marzyeh Ghassemi , Shalmali Joshi

Personalized decision making requires the knowledge of potential outcomes under different treatments, and confidence intervals about the potential outcomes further enrich this decision-making process and improve its reliability in…

Machine Learning · Computer Science 2024-05-22 Zonghao Chen , Ruocheng Guo , Jean-François Ton , Yang Liu

In light of the widespread success of generative models, a significant amount of research has gone into speeding up their sampling time. However, generative models are often sampled multiple times to obtain a diverse set incurring a cost…

Machine Learning · Computer Science 2023-11-27 Gabriele Corso , Yilun Xu , Valentin de Bortoli , Regina Barzilay , Tommi Jaakkola

Many segmentation tasks, such as medical image segmentation or future state prediction, are inherently ambiguous, meaning that multiple predictions are equally correct. Current methods typically rely on generative models to capture this…

Computer Vision and Pattern Recognition · Computer Science 2026-03-23 Sebastian Gerard , Josephine Sullivan

In this paper we propose a data augmentation method for time series with irregular sampling, Time-Conditional Generative Adversarial Network (T-CGAN). Our approach is based on Conditional Generative Adversarial Networks (CGAN), where the…

Machine Learning · Computer Science 2019-02-04 Giorgia Ramponi , Pavlos Protopapas , Marco Brambilla , Ryan Janssen

Real-world time series data are often generated from several sources of variation. Learning representations that capture the factors contributing to this variability enables a better understanding of the data via its underlying generative…

Machine Learning · Computer Science 2022-02-14 Sana Tonekaboni , Chun-Liang Li , Sercan Arik , Anna Goldenberg , Tomas Pfister

Conditional generation models for longitudinal sequences can produce new or modified trajectories given a conditioning input. However, they often lack control over when the condition should take effect (timing) and which variables it should…

Machine Learning · Computer Science 2026-03-10 Michelle M. Li , Kevin Li , Yasha Ektefaie , Ying Jin , Yepeng Huang , Shvat Messica , Tianxi Cai , Marinka Zitnik

This study investigates human-computer interface generation based on diffusion models to overcome the limitations of traditional template-based design and fixed rule-driven methods. It first analyzes the key challenges of interface…

Human-Computer Interaction · Computer Science 2026-01-13 Rui Liu , Liuqingqing Yang , Runsheng Zhang , Shixiao Wang

Recent work has made important contributions in the development of causally-interpretable meta-analysis. These methods transport treatment effects estimated in a collection of randomized trials to a target population of interest. Ideally,…

Methodology · Statistics 2023-02-08 Justin M. Clark , Kollin W. Rott , James S. Hodges , Jared D. Huling

The use of machine learning systems to support decision making in healthcare raises questions as to what extent these systems may introduce or exacerbate disparities in care for historically underrepresented and mistreated groups, due to…

Machine Learning · Computer Science 2019-07-16 Stephen Pfohl , Tony Duan , Daisy Yi Ding , Nigam H. Shah

Medical professionals evaluating alternative treatment plans for a patient often encounter time varying confounders, or covariates that affect both the future treatment assignment and the patient outcome. The recently proposed…

Machine Learning · Computer Science 2022-01-21 Garima Gupta , Lovekesh Vig , Gautam Shroff

Conditional diffusion probabilistic models can model the distribution of natural images and can generate diverse and realistic samples based on given conditions. However, oftentimes their results can be unrealistic with observable color…

Computer Vision and Pattern Recognition · Computer Science 2022-12-15 Kangfu Mei , Nithin Gopalakrishnan Nair , Vishal M. Patel

Causal inference, estimating causal effects from observational data, is a fundamental tool in many disciplines. Of particular importance across a variety of domains is the continuous treatment setting, where the variable of intervention has…

Machine Learning · Computer Science 2026-05-15 Christopher Stith , Medha Barath , Vahid Balazadeh , Jesse C. Cresswell , Rahul G. Krishnan
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