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Gene regulatory networks exhibit remarkable stability, maintaining functional phenotypes despite genetic and environmental perturbations. Discrete dynamical models, such as Boolean networks, provide systems biologists with a tractable…

Molecular Networks · Quantitative Biology 2025-11-25 Claus Kadelka

Systems of dynamical interactions between competing species can be used to model many complex systems, and can be mathematically described by {\em random} networks. Understanding how patterns of activity arise in such systems is important…

Adaptation and Self-Organizing Systems · Physics 2016-01-21 Nick McCullen , Thomas Wagenknecht

The study of the interplay between the structure and dynamics of complex multilevel systems is a pressing challenge nowadays. In this paper, we use a semi-annealed approximation to study the stability properties of Random Boolean Networks…

Physics and Society · Physics 2012-10-31 Emanuele Cozzo , Alex Arenas , Yamir Moreno

Recurrent neural networks have been extensively studied in the context of neuroscience and machine learning due to their ability to implement complex computations. While substantial progress in designing effective learning algorithms has…

Neurons and Cognition · Quantitative Biology 2019-01-21 Francesca Mastrogiuseppe , Srdjan Ostojic

Genetic regulatory networks are usually modeled by systems of coupled differential equations and by finite state models, better known as logical networks, are also used. In this paper we consider a class of models of regulatory networks…

Dynamical Systems · Mathematics 2015-06-26 Ricardo Lima , Edgardo Ugalde

The global dynamics of gene regulatory networks are known to show robustness to perturbations in the form of intrinsic and extrinsic noise, as well as mutations of individual genes. One molecular mechanism underlying this robustness has…

Molecular Networks · Quantitative Biology 2015-06-15 Claus Kadelka , David Murrugarra , Reinhard Laubenbacher

Many real-world phenomena are best represented as interaction networks with dynamic structures (e.g., transaction networks, social networks, traffic networks). Interaction networks capture flow of data which is transferred between their…

Social and Information Networks · Computer Science 2018-10-22 Chrysanthi Kosyfaki , Nikos Mamoulis , Evaggelia Pitoura , Panayiotis Tsaparas

The native conformation of structured proteins is stabilized by a complex network of interactions. We analyzed the elementary patterns that constitute such network and ranked them according to their importance in shaping protein sequence…

Biomolecules · Quantitative Biology 2022-04-11 M. Tajana , A. Trovato , G. Tiana

We consider a sparse random network of excitatory leaky integrate-and-fire neurons with short-term synaptic depression. Furthermore to mimic the dynamics of a brain circuit in its first stages of development we introduce for each neuron…

Neurons and Cognition · Quantitative Biology 2017-03-14 S. Luccioli , A. Barzilai , E. Ben-Jacob , P. Bonifazi , A. Torcini

The interaction of distinct units in physical, social, biological and technological systems naturally gives rise to complex network structures. Networks have constantly been in the focus of research for the last decade, with considerable…

Physics and Society · Physics 2012-08-20 Tamás Nepusz , Tamás Vicsek

Group formation and coordination are fundamental characteristics of living systems, essential for performing tasks and ensuring survival. Interactions between individuals play a key role in group formation, and the impact of resource…

Models of strategy evolution on static networks help us understand how population structure can promote the spread of traits like cooperation. One key mechanism is the formation of altruistic spatial clusters, where neighbors of a…

Physics and Society · Physics 2023-09-07 Qi Su , Alex McAvoy , Joshua B. Plotkin

Robustness to mutations and noise has been shown to evolve through stabilizing selection for optimal phenotypes in model gene regulatory networks. The ability to evolve robust mutants is known to depend on the network architecture. How do…

Molecular Networks · Quantitative Biology 2008-07-07 Volkan Sevim , Per Arne Rikvold

Over the last two decades, network science has greatly advanced our understanding of how the collective behaviors of a complex system emerge from the interactions among its basic units. Multiplex networks, i.e. networks with many layers,…

With an increasing amount of observations on the dynamics of many complex systems, it is required to reveal the underlying mechanisms behind these complex dynamics, which is fundamentally important in many scientific fields such as climate,…

Neurons and Cognition · Quantitative Biology 2025-03-19 Zhendong Yu , Haiping Huang

The most widely used techniques for community detection in networks, including methods based on modularity, statistical inference, and information theoretic arguments, all work by optimizing objective functions that measure the quality of…

Social and Information Networks · Computer Science 2020-05-13 Maria A. Riolo , M. E. J. Newman

The community structure of complex networks reveals both their organization and hidden relationships among their constituents. Most community detection methods currently available are not deterministic, and their results typically depend on…

Physics and Society · Physics 2012-03-29 Andrea Lancichinetti , Santo Fortunato

Cascading chains of events are a salient feature of many real-world social, biological, and financial networks. In social networks, social reciprocity accounts for retaliations in gang interactions, proxy wars in nation-state conflicts, or…

Machine Learning · Statistics 2016-07-05 Eric C. Hall , Rebecca M. Willett

Complex networks as the World Wide Web, the web of human sexual contacts or criminal networks often do not have an engineered architecture but instead are self-organized by the actions of a large number of individuals. From these local…

Disordered Systems and Neural Networks · Physics 2007-05-23 Holger Ebel , Joern Davidsen , Stefan Bornholdt

Networks are powerful tools for modeling interactions in complex systems. While traditional networks use scalar edge weights, many real-world systems involve multidimensional interactions. For example, in social networks, individuals often…

Social and Information Networks · Computer Science 2024-10-08 Yu Tian , Sadamori Kojaku , Hiroki Sayama , Renaud Lambiotte