Related papers: Synchronous replication initiation of multiple ori…
Due to recent advances in synthetic biology and artificial life, the origin of life is currently a hot topic of research. We review the literature and argue that the two traditionally competing "replicator-first" and "metabolism-first"…
The functional significance of correlations between action potentials of neurons is still a matter of vivid debates. In particular it is presently unclear how much synchrony is caused by afferent synchronized events and how much is…
The identification of cellular objectives is one of the central topics in the research of microbial metabolic networks. In particular, the information about a cellular objective is needed in flux balance analysis which is a commonly used…
Synthetic biology sets out to implement new functions in cells, and to develop a deeper understanding of biological design principles. In 2000, Elowitz and Leibler showed that by rational design of the reaction network, and using existing…
The sources, which generate atom-photon quantum correlations or entanglement based on quantum memory, are basic blocks for building quantum repeaters (QRs). For achieving highly entanglement-generation rates in ensemble-based QRs, spatial-,…
The E.coli transcription network has an essentially feedforward structure, with, however, abundant feedback at the level of self-regulations. Here, we investigate how these properties emerged during evolution. An assessment of the role of…
Brains can process sensory information from different modalities at astonishing speed; this is surprising as the integration of inputs through the membrane of each individual neuron already causes a delayed response. Neuronal recordings…
Biological microfilaments exhibit a variety of synchronization modes. Recent experiments observed that a pair of isolated eukaryotic flagella, coupled solely via the fluid medium, display synchrony at nontrivial phase-lags in addition to…
Turnover of regulatory sequence and function is an important part of molecular evolution. But what are the modes of sequence evolution leading to rapid formation and loss of regulatory sites? Here, we show that a large fraction of…
Genome-scale metabolic models have become a fundamental tool for examining metabolic principles. However, metabolism is not solely characterized by the underlying biochemical reactions and catalyzing enzymes, but also affected by regulatory…
A bacterial colony may develop a small number of cells genetically identical to, but phenotypically different from other normally growing bacteria. These so-called persister cells keep themselves in a dormant state and thus are insensitive…
Originally developed to elucidate the mechanisms of natural selection in bacteria, the Luria-Delbr\"uck model assumed that cells are intrinsically capable of dividing an unlimited number of times. This assumption however, is not true for…
The bacterial SOS response is a cellular reaction to DNA damage, that, among other actions, triggers the expression of colicin - toxic bacteriocins in Escherichia coli that are released to kill close relatives competing for resources.…
Cell fate decisions in multicellular organisms are precisely coordinated, leading to highly reproducible macroscopic outcomes of developmental processes. The origins of this reproducibility can be found at the molecular level during the…
Motivation: Genome rearrangement plays an important role in evolutionary biology and has profound impacts on phenotype in organisms ranging from microbes to humans. The mechanisms for genome rearrangement events remain unclear. Lots of…
Neural-network processing in machine learning applications relies on layer synchronization. This is practiced even in artificial Spiking Neural Networks (SNNs), which are touted as consistent with neurobiology, in spite of processing in the…
Synchronization of actively oscillating organelles such as cilia and flagella facilitates self-propulsion of cells and pumping fluid in low Reynolds number environments. To understand the key mechanism behind synchronization induced by…
Bone marrow stromal cells (BMSC) -- which include skeletal stem cells -- are a promising tool in regenerative medicine. However, their heterogeneous and unpredictable in vivo behaviour remains a critical barrier preventing the development…
The cell cycle is an orderly sequence of events which ultimately lead to the division of a single cell into two daughter cells. In the case of DNA damage by radiation or chemicals, the damage checkpoints in the $G_{1}$ and $G_{2}$ phases of…
Cellular automata are widely used to model natural or artificial systems. Classically they are run with perfect synchrony, i.e., the local rule is applied to each cell at each time step. A possible modification of the updating scheme…