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Excessively high, neural synchronisation has been associated with epileptic seizures, one of the most common brain diseases worldwide. A better understanding of neural synchronisation mechanisms can thus help control or even treat epilepsy.…

The maximum possible throughput (or the rate of job completion) of a multi-server system is typically the sum of the service rates of individual servers. Recent work shows that launching multiple replicas of a job and canceling them as soon…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-12-29 Gauri Joshi , Dhruva Kaushal

We report experimental studies of synchronization phenomena in a pair of biological neurons that interact through naturally occurring, electrical coupling. When these neurons generate irregular bursts of spikes, the natural coupling…

Can prelife proceed without cell division? A recently proposed mechanism suggests that transient compartmentalization could have preceded cell division in prebiotic scenarios. Here, we study transient compartmentalization dynamics in the…

Populations and Evolution · Quantitative Biology 2019-12-17 Alex Blokhuis , Philippe Nghe , Luca Peliti , David Lacoste

We consider a continuous-time branching random walk on $\mathbb{Z}$ in a random non homogeneous environment. Particles can walk on the lattice points or disappear with random intensities. The process starts with one particle at initial time…

Probability · Mathematics 2023-12-12 Vladimir Kutsenko , Stanislav Molchanov , Elena Yarovaya

The possibility for detuned spins to display synchronous oscillations in local observables is analyzed in the presence of collective dissipation and incoherent pumping. We show that there exist two distinct mechanisms that can give rise to…

Quantum Physics · Physics 2021-05-21 Albert Cabot , Gian Luca Giorgi , Roberta Zambrini

Models for resident infectious diseases, like the SIRS model, may settle into an endemic state with constant numbers of susceptible ($S$), infected ($I$) and recovered ($R$) individuals, where recovered individuals attain a temporary…

Populations and Evolution · Quantitative Biology 2024-11-05 Daniel Henrik Nevermann , Claudius Gros

Stem cells are characterized by their ability to self-renew, as well as to differentiate and give rise to new populations of cells. Stem cell divisions are crucial for generative processes that occur during early development, and later in…

Applications · Statistics 2025-08-29 Haim Bar , Huyen Nguyen , Joanne Conover

We unravel how functional plasticity and redundancy are essential mechanisms underlying the ability to survive of metabolic networks. We perform an exhaustive computational screening of synthetic lethal reaction pairs in Escherichia coli in…

Molecular Networks · Quantitative Biology 2015-06-17 Oriol Güell , Francesc Sagués , M. Ángeles Serrano

Neural networks can synchronize by learning from each other. In the case of discrete weights full synchronization is achieved in a finite number of steps. Additional networks can be trained by using the inputs and outputs generated during…

Disordered Systems and Neural Networks · Physics 2007-11-16 Andreas Ruttor

Data reconciliation in general, and filesystem synchronization in particular, lacks rigorous theoretical foundation. This paper presents, for the first time, a complete analysis of synchronization for two replicas of a theoretical…

Information Theory · Computer Science 2022-11-15 Elod P. Csirmaz , Laszlo Csirmaz

Elucidating the architecture and dynamics of large scale genetic regulatory networks of cells is an important goal in systems biology. We study the system level dynamical properties of the genetic network of Escherichia coli that regulates…

Molecular Networks · Quantitative Biology 2008-02-29 Areejit Samal , Sanjay Jain

One typical use case of large-scale distributed computing in data centers is to decompose a computation job into many independent tasks and run them in parallel on different machines, sometimes known as the "embarrassingly parallel"…

Distributed, Parallel, and Cluster Computing · Computer Science 2014-04-07 Da Wang , Gauri Joshi , Gregory Wornell

We have performed a statistical analysis of the spatial distribution of operons in the transcriptional regulation network of Escherichia coli. The analysis reveals that operons that regulate each other and operons that are coregulated tend…

Molecular Networks · Quantitative Biology 2007-05-23 P. B. Warren , P. R. ten Wolde

The dynamics of gene transcription is tightly regulated in eukaryotes. Recent experiments have revealed various kinds of transcriptional dynamics, such as RNA polymerase II pausing, that involves regulation at the transcription initiation…

Cell Behavior · Quantitative Biology 2015-08-11 Yucheng Hu , John Lowengrub

Multidimensional nucleosynthesis studies with hundreds of nuclei linked through thousands of nuclear processes are still computationally prohibitive. To date, most nucleosynthesis studies rely either on hydrostatic/hydrodynamic simulations…

Solar and Stellar Astrophysics · Physics 2018-11-26 David Martin , Jordi Jose , Richard Longland

Flagellated bacteria, such as Escherichia coli, perform directed motion in gradients of concentration of attractants and repellents in a process called chemotaxis. The E. coli chemotaxis signaling pathway is a model for signal transduction,…

Biological Physics · Physics 2015-03-11 Anne-Florence Bitbol , Ned S. Wingreen

In this work, we focus on the problem of replay clocks (RepCL). The need for replay clocks arises from the observation that analyzing distributed computation for all desired properties of interest may not be feasible in an online…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-11-15 Ishaan Lagwankar , Sandeep S Kulkarni

We present an analytically solvable model for self-assembly of a molecular complex on a filament. The process is driven by a seed molecule that undergoes facilitated diffusion, which is a search strategy that combines diffusion in…

Statistical Mechanics · Physics 2015-11-04 Ziya Kalay

The problem of reconstructing a source sequence with the presence of decoder side-information that is mis-synchronized to the source due to deletions is studied in a distributed source coding framework. Motivated by practical applications,…

Information Theory · Computer Science 2016-11-17 Nan Ma , Kannan Ramchandran , David Tse
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