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The accurate extraction of clinical information from electronic medical records is particularly critical to clinical research but require much trained expertise and manual labor. In this study we developed a robust system for automated…

This paper presents medBERTde, a pre-trained German BERT model specifically designed for the German medical domain. The model has been trained on a large corpus of 4.7 Million German medical documents and has been shown to achieve new…

Large language models (LLMs) have demonstrated strong performance on medical benchmarks, including question answering and diagnosis. To enable their use in clinical settings, LLMs are typically further adapted through continued pretraining…

A visual-language model (VLM) pre-trained on natural images and text pairs poses a significant barrier when applied to medical contexts due to domain shift. Yet, adapting or fine-tuning these VLMs for medical use presents considerable…

Computer Vision and Pattern Recognition · Computer Science 2024-05-31 Aisha Urooj Khan , John Garrett , Tyler Bradshaw , Lonie Salkowski , Jiwoong Jason Jeong , Amara Tariq , Imon Banerjee

The clinical integration of deep learning models for brain tumor diagnosis in neuro-oncology is severely constrained by limited expert-annotated MRI data and substantial inter-institutional domain shift arising from variations in scanners,…

Computer Vision and Pattern Recognition · Computer Science 2026-05-06 Sapna Sachan , Amulya Kumar Mahto , Prashant Wagambar Patil

Convolutional neural networks (CNNs) have led to significant improvements in the semantic segmentation of images. When source and target datasets come from different modalities, CNN performance suffers due to domain shift. In such cases…

Computer Vision and Pattern Recognition · Computer Science 2022-10-10 Serban Stan , Mohammad Rostami

Both medical care and observational studies in oncology require a thorough understanding of a patient's disease progression and treatment history, often elaborately documented in clinical notes. Despite their vital role, no current oncology…

Computation and Language · Computer Science 2024-03-18 Madhumita Sushil , Vanessa E. Kennedy , Divneet Mandair , Brenda Y. Miao , Travis Zack , Atul J. Butte

Domain adaptation, a pivotal branch of transfer learning, aims to enhance the performance of machine learning models when deployed in target domains with distinct data distributions. This is particularly critical for object detection tasks,…

Computer Vision and Pattern Recognition · Computer Science 2025-01-07 Helia Mohamadi , Mohammad Ali Keyvanrad , Mohammad Reza Mohammadi

Objectives: To adapt and evaluate a deep learning language model for answering why-questions based on patient-specific clinical text. Materials and Methods: Bidirectional encoder representations from transformers (BERT) models were trained…

Computation and Language · Computer Science 2020-03-09 Andrew Wen , Mohamed Y. Elwazir , Sungrim Moon , Jungwei Fan

The recent success of neural machine translation models relies on the availability of high quality, in-domain data. Domain adaptation is required when domain-specific data is scarce or nonexistent. Previous unsupervised domain adaptation…

Computation and Language · Computer Science 2019-08-29 Zi-Yi Dou , Junjie Hu , Antonios Anastasopoulos , Graham Neubig

The accurate prediction of drug responses remains a formidable challenge, particularly at the single-cell level and in clinical treatment contexts. Some studies employ transfer learning techniques to predict drug responses in individual…

Machine Learning · Computer Science 2025-06-03 Ran Song , Yinpu Bai , Hui Liu

Recent advances in natural language processing (NLP) have been driven bypretrained language models like BERT, RoBERTa, T5, and GPT. Thesemodels excel at understanding complex texts, but biomedical literature, withits domain-specific…

Computation and Language · Computer Science 2025-07-28 K. Sahit Reddy , N. Ragavenderan , Vasanth K. , Ganesh N. Naik , Vishalakshi Prabhu , Nagaraja G. S

Large and Transformer-based language models perform outstandingly in various downstream tasks. However, there is limited understanding regarding how these models internalize linguistic knowledge, so various linguistic benchmarks have…

Computation and Language · Computer Science 2025-08-26 David Beauchemin , Richard Khoury

Self-driving laboratories based on large language models promise to transform scientific discovery through general experimental automation. However, realizing this vision on precision platforms remains challenging, requiring deterministic…

Applied Physics · Physics 2026-04-07 Zhuo Diao , Kouma Matsumoto , Linfeng Hou , Masahiro Ohara , Hayato Yamashita , Masayuki Abe

Language models like BERT and SpanBERT pretrained on open-domain data have obtained impressive gains on various NLP tasks. In this paper, we probe the effectiveness of domain-adaptive pretraining objectives on downstream tasks. In…

Computation and Language · Computer Science 2021-05-31 Han Wu , Kun Xu , Linfeng Song , Lifeng Jin , Haisong Zhang , Linqi Song

Multi-modal data abounds in biomedicine, such as radiology images and reports. Interpreting this data at scale is essential for improving clinical care and accelerating clinical research. Biomedical text with its complex semantics poses…

The insertion of deep learning in medical image analysis had lead to the development of state-of-the art strategies in several applications such a disease classification, as well as abnormality detection and segmentation. However, even the…

Image and Video Processing · Electrical Eng. & Systems 2022-02-24 Mauricio Orbes-Arteaga , Thomas Varsavsky , Lauge Sorensen , Mads Nielsen , Akshay Pai , Sebastien Ourselin , Marc Modat , M Jorge Cardoso

Domain adaptation is the supervised learning setting in which the training and test data are sampled from different distributions: training data is sampled from a source domain, whilst test data is sampled from a target domain. This paper…

Machine Learning · Statistics 2016-10-21 Wouter M. Kouw , Jesse H. Krijthe , Marco Loog , Laurens J. P. van der Maaten

We investigate whether general-domain large language models such as GPT-4 Turbo can perform risk stratification and predict post-operative outcome measures using a description of the procedure and a patient's clinical notes derived from the…

Artificial Intelligence · Computer Science 2024-01-04 Philip Chung , Christine T Fong , Andrew M Walters , Nima Aghaeepour , Meliha Yetisgen , Vikas N O'Reilly-Shah

Pre-trained large language models(LLMs) have attracted increasing attention in biomedical domains due to their success in natural language processing. However, the complex traits and heterogeneity of multi-sources genomics data pose…

Computation and Language · Computer Science 2025-11-25 Yanjun Lyu , Zihao Wu , Lu Zhang , Jing Zhang , Yiwei Li , Wei Ruan , Zhengliang Liu , Zeyu Zhang , Xiang Li , Rongjie Liu , Chao Huang , Wentao Li , Tianming Liu , Dajiang Zhu
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