Related papers: Pulse Parameter Optimization Method for Ultra High…
Conventional planning objectives in optimization of intensity-modulated radiotherapy treatment (IMRT) plans are designed to minimize the violation of dose-volume histogram (DVH) thresholds using penalty functions. Although successful in…
Controlling the intensity distribution of laser pulses in the focal region is essential for optimizing optically generated plasma waveguides and enabling advanced plasma acceleration techniques, including dephasingless wakefield…
Purpose: The FLASH effect, which reduces the radiosensitivity of healthy tissue while maintaining tumor control at high dose rates, has shown potential for improving radiation therapy. Conformal FLASH proton therapy involves advanced…
In this paper, a novel fine timing algorithm has been tested and developed to synchronize Ultra-Wideband (UWB) signals with pulse position modulation (PPM). By applying this algorithm, we evaluate timing algorithms in both data-aided (DA)…
We use Bayesian optimization in combination with three-dimensional particle-in-cell simulations to determine the optimal laser and plasma parameters that, for a given laser pulse energy, maximize the cut-off energy of an electron beam…
Optimal pulse patterns (OPPs) are a modulation method in which the switching angles and levels of a switching signal are computed via an offline optimization procedure to minimize a performance metric, typically the harmonic distortions of…
Purpose: The purpose of this work is to develop a new approach for high spatial resolution dosimetry based on Raman micro-spectroscopy scanning of radiochromic film (RCF). We generate dose calibration curves over an extended dose range from…
Ultra-intense laser-matter interactions are often difficult to predict from first principles because of the complexity of plasma processes and the many degrees of freedom relating to the laser and target parameters. An important approach to…
High harmonic generation (HHG) in gaseous media provides a robust method for producing coherent extreme-ultraviolet (EUV) radiation and attosecond pulses. However, the spectral and temporal properties of these pulses -- such as bandwidth…
Radiotherapy is sensitive to executional and preparational uncertainties that propagate to uncertainty in dose and plan quality indicators like dose-volume histograms (DVHs). Current approaches to quantify and mitigate such uncertainties…
In this study we explore the optimization of laser pulse duration to obtain the shortest possible pulse. We do this by employing a feedback loop between a pulse shaper and pulse duration measurements. We apply to this problem several…
The interaction of multipetawatt lasers with plasma is a complex multiparameter problem, providing a wide field for fundamental research and opening up great opportunities for creating unique sources of high-energy electrons and positrons,…
As Ultrafast laser technology advances towards ever higher peak and average powers, generating sub-50 fs pulses from laser architectures that exhibit best power-scaling capabilities remains a major challenge. Here, we present a very compact…
The radiation pressure acceleration regime of laser ion acceleration requires high intensity laser pulses to function efficiently. Moreover the foil should be opaque for incident radiation during the interaction to ensure maximum momentum…
Research on ultra-high dose rate (UHDR) radiation therapy has indicated its potential to spare normal tissue while maintaining equivalent tumor control compared to conventional treatments. First clinical trials are underway. The randomized…
We propose to use ultra-high intensity laser pulses with wavefront rotation (WFR) to produce short, ultra-intense surface plasma waves (SPW) on grating targets for electron acceleration. Combining a smart grating design with optimal WFR…
This work explores the feasibility of employing ultrasound (US) US technology in a wrist-worn IoT device for low-power, high-fidelity heart-rate (HR) extraction. US offers deep tissue penetration and can monitor pulsatile arterial blood…
Scattering of ultraintense short laser pulses off relativistic electrons allows one to generate a large number of X- or $\gamma$-ray photons with the expense of the spectral width---temporal pulsing of the laser inevitable leads to…
This paper proposes a high-precision time measurement method based on digital frequency-domain phase-fitting (DFPF) by using the digitized nuclear pulses. The averaging effect inherent in the frequency-domain cross-correlation and…
Temporally modulated pulsed radiotherapy (TMPRT) delivers conventional fraction doses of radiation using temporally separated pulses of low doses (<30 cGy) yielding fraction-effective dose rates of around 6.7 cGy/min with the goal to…