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This paper addresses the task of anomaly diagnosis when the underlying data generation process has a complex spatio-temporal (ST) dependency. The key technical challenge is to extract actionable insights from the dependency tensor…

Machine Learning · Computer Science 2023-05-30 Jokin Labaien , Tsuyoshi Idé , Pin-Yu Chen , Ekhi Zugasti , Xabier De Carlos

The integration of spatial multi-omics data from single tissues is crucial for advancing biological research. However, a significant data imbalance impedes progress: while spatial transcriptomics data is relatively abundant, spatial…

Artificial Intelligence · Computer Science 2026-02-06 Zhaorui Jiang , Yingfang Yuan , Lei Hu , Wei Pang

Missing data in tabular dataset is a common issue as the performance of downstream tasks usually depends on the completeness of the training dataset. Previous missing data imputation methods focus on numeric and categorical columns, but we…

Computation and Language · Computer Science 2024-11-04 Ting-Ruen Wei , Yuan Wang , Yoshitaka Inoue , Hsin-Tai Wu , Yi Fang

Single-cell gene expression measurements encode variability spanning molecular noise, cell-to-cell heterogeneity, and technical artifacts. Mechanistic stochastic models provide powerful approaches to disentangle these sources, yet inferring…

Quantitative Methods · Quantitative Biology 2025-09-19 Christopher E. Miles

Attention-based models, such as Transformer, excel across various tasks but lack a comprehensive theoretical understanding, especially regarding token-wise sparsity and internal linear representations. To address this gap, we introduce the…

Machine Learning · Statistics 2025-02-27 Pierre Marion , Raphaël Berthier , Gérard Biau , Claire Boyer

Pretrained encoders for mathematical texts have achieved significant improvements on various tasks such as formula classification and information retrieval. Yet they remain limited in representing and capturing student strategies for entire…

Computers and Society · Computer Science 2026-04-13 Siddhartha Pradhan , Ethan Prihar , Erin Ottmar

Learning representations on large-sized graphs is a long-standing challenge due to the inter-dependence nature involved in massive data points. Transformers, as an emerging class of foundation encoders for graph-structured data, have shown…

Machine Learning · Computer Science 2024-08-19 Qitian Wu , Wentao Zhao , Chenxiao Yang , Hengrui Zhang , Fan Nie , Haitian Jiang , Yatao Bian , Junchi Yan

Spatial transcriptomics is a technology that captures gene expression levels at different spatial locations, widely used in tumor microenvironment analysis and molecular profiling of histopathology, providing valuable insights into…

Computer Vision and Pattern Recognition · Computer Science 2025-06-11 Junzhuo Liu , Markus Eckstein , Zhixiang Wang , Friedrich Feuerhake , Dorit Merhof

Multivariate time series forecasting focuses on predicting future values based on historical context. State-of-the-art sequence-to-sequence models rely on neural attention between timesteps, which allows for temporal learning but fails to…

Machine Learning · Computer Science 2023-03-21 Jake Grigsby , Zhe Wang , Nam Nguyen , Yanjun Qi

The question of what kinds of linguistic information are encoded in different layers of Transformer-based language models is of considerable interest for the NLP community. Existing work, however, has overwhelmingly focused on word-level…

Computation and Language · Computer Science 2023-10-19 Dmitry Nikolaev , Sebastian Padó

Spatial transcriptomics (ST) technologies can be used to align transcriptomes with histopathological morphology, presenting exciting new opportunities for biomolecular discovery. Using ST data, we construct a novel framework, GeneFlow, to…

Quantitative Methods · Quantitative Biology 2025-11-04 Mengbo Wang , Shourya Verma , Aditya Malusare , Luopin Wang , Yiyang Lu , Vaneet Aggarwal , Mario Sola , Ananth Grama , Nadia Atallah Lanman

Continuous representations of logic formulae allow us to integrate symbolic knowledge into data-driven learning algorithms. If such embeddings are semantically consistent, i.e. if similar specifications are mapped into nearby vectors, they…

Computation and Language · Computer Science 2025-09-17 Sara Candussio , Gaia Saveri , Gabriele Sarti , Luca Bortolussi

Spatial grounding, the process of associating natural language expressions with corresponding image regions, has rapidly advanced due to the introduction of transformer-based models, significantly enhancing multimodal representation and…

Computer Vision and Pattern Recognition · Computer Science 2025-07-18 Ijazul Haq , Muhammad Saqib , Yingjie Zhang

Semantic segmentation based on sparse annotation has advanced in recent years. It labels only part of each object in the image, leaving the remainder unlabeled. Most of the existing approaches are time-consuming and often necessitate a…

Computer Vision and Pattern Recognition · Computer Science 2023-02-28 Hui Su , Yue Ye , Wei Hua , Lechao Cheng , Mingli Song

Missing values are a notable challenge when analysing mass spectrometry-based proteomics data. While the field is still actively debating on the best practices, the challenge increased with the emergence of mass spectrometry-based…

Quantitative Methods · Quantitative Biology 2023-07-12 Christophe Vanderaa , Laurent Gatto

Transformer models have become state-of-the-art in decoding stimuli and behavior from neural activity, significantly advancing neuroscience research. Yet greater transparency in their decision-making processes would substantially enhance…

Quantitative Methods · Quantitative Biology 2025-06-18 Laurence Freeman , Philip Shamash , Vinam Arora , Caswell Barry , Tiago Branco , Eva Dyer

Linear probes and sparse autoencoders consistently recover meaningful structure from transformer representations -- yet why should such simple methods succeed in deep, nonlinear systems? We show this is not merely an empirical regularity…

Machine Learning · Computer Science 2026-02-11 Andres Saurez , Yousung Lee , Dongsoo Har

When sensors collect spatio-temporal data in a large geographical area, the existence of missing data cannot be escaped. Missing data negatively impacts the performance of data analysis and machine learning algorithms. In this paper, we…

Machine Learning · Computer Science 2019-04-30 Reza Asadi , Amelia Regan

The advent of single-cell technology has significantly improved our understanding of cellular states and subpopulations in various tissues under normal and diseased conditions by employing data-driven approaches such as clustering and…

Inferring spatially resolved gene expression from histology images offers a cost-effective complement to spatial transcriptomics (ST). However, existing methods reduce this task to a simple morphology-to-expression mapping, where visual…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Junchao Zhu , Ruining Deng , Junlin Guo , Tianyuan Yao , Chongyu Qu , Juming Xiong , Zhengyi Lu , Yanfan Zhu , Marilyn Lionts , Yuechen Yang , Yu Wang , Shilin Zhao , Haichun Yang , Yuankai Huo
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