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One of the major challenges arising from single-cell transcriptomics experiments is the question of how to annotate the associated single-cell transcriptomic profiles. Because of the large size and the high dimensionality of the data,…

Genomics · Quantitative Biology 2024-09-11 Malek Senoussi , Thierry Artières , Paul Villoutreix

Single-cell transcriptomics and proteomics have become a great source for data-driven insights into biology, enabling the use of advanced deep learning methods to understand cellular heterogeneity and gene expression at the single-cell…

Genomics · Quantitative Biology 2025-12-15 Hiren Madhu , João Felipe Rocha , Tinglin Huang , Siddharth Viswanath , Smita Krishnaswamy , Rex Ying

Recently, there has been a surge of Transformer-based solutions for the long-term time series forecasting (LTSF) task. Despite the growing performance over the past few years, we question the validity of this line of research in this work.…

Artificial Intelligence · Computer Science 2022-08-18 Ailing Zeng , Muxi Chen , Lei Zhang , Qiang Xu

Transformers, adapted from natural language processing, are emerging as a leading approach for graph representation learning. Contemporary graph transformers often treat nodes or edges as separate tokens. This approach leads to…

Machine Learning · Computer Science 2023-10-04 Zihan Pengmei , Zimu Li , Chih-chan Tien , Risi Kondor , Aaron R. Dinner

The technology to generate Spatially Resolved Transcriptomics (SRT) data is rapidly being improved and applied to investigate a variety of biological tissues. The ability to interrogate how spatially localised gene expression can lend new…

Quantitative Methods · Quantitative Biology 2021-08-04 Natalie Charitakis , Mirana Ramialison , Hieu T. Nim

Medical tabular data, abundant in Electronic Health Records (EHRs), is a valuable resource for diverse medical tasks such as risk prediction. While deep learning approaches, particularly transformer-based models, have shown remarkable…

Computation and Language · Computer Science 2025-04-11 Yucheng Ruan , Xiang Lan , Daniel J. Tan , Hairil Rizal Abdullah , Mengling Feng

Spatiotemporal learning is challenging due to the intricate interplay between spatial and temporal dependencies, the high dimensionality of the data, and scalability constraints. These challenges are further amplified in scientific domains,…

Machine Learning · Computer Science 2025-04-17 David Keetae Park , Xihaier Luo , Guang Zhao , Seungjun Lee , Miruna Oprescu , Shinjae Yoo

Self-supervised training methods for transformers have demonstrated remarkable performance across various domains. Previous transformer-based models, such as masked autoencoders (MAE), typically utilize a single normalization layer for both…

Computation and Language · Computer Science 2023-11-30 Xiaohui Chen , Yinkai Wang , Yuanqi Du , Soha Hassoun , Li-Ping Liu

Vision transformers have achieved great successes in many computer vision tasks. Most methods generate vision tokens by splitting an image into a regular and fixed grid and treating each cell as a token. However, not all regions are equally…

Computer Vision and Pattern Recognition · Computer Science 2022-04-22 Wang Zeng , Sheng Jin , Wentao Liu , Chen Qian , Ping Luo , Wanli Ouyang , Xiaogang Wang

Recent advances in cellular research demonstrate that scRNA-seq characterizes cellular heterogeneity, while spatial transcriptomics reveals the spatial distribution of gene expression. Cell representation is the fundamental issue in the two…

Genomics · Quantitative Biology 2025-01-16 Kai Zheng , Shaokai Wang , Yunpei Xu , Qiming Lei , Qichang Zhao , Xiao Liang , Qilong Feng , Yaohang Li , Min Li , Jinhui Xu , Jianxin Wang

Deep learning has achieved remarkable success in modeling sequential data, including event sequences, temporal point processes, and irregular time series. Recently, transformers have largely replaced recurrent networks in these tasks.…

Machine Learning · Computer Science 2025-08-05 Ivan Karpukhin , Andrey Savchenko

Transformers have offered a new methodology of designing neural networks for visual recognition. Compared to convolutional networks, Transformers enjoy the ability of referring to global features at each stage, yet the attention module…

Computer Vision and Pattern Recognition · Computer Science 2022-03-28 Jiemin Fang , Lingxi Xie , Xinggang Wang , Xiaopeng Zhang , Wenyu Liu , Qi Tian

This paper proposes a novel transformer-based framework that aims to enhance weakly supervised semantic segmentation (WSSS) by generating accurate class-specific object localization maps as pseudo labels. Building upon the observation that…

Computer Vision and Pattern Recognition · Computer Science 2023-08-08 Lian Xu , Mohammed Bennamoun , Farid Boussaid , Hamid Laga , Wanli Ouyang , Dan Xu

Indoor monocular semantic scene completion (MSSC) is notably more challenging than its outdoor counterpart due to complex spatial layouts and severe occlusions. While transformers are well suited for modeling global dependencies, their high…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Xuzhi Wang , Xinran Wu , Song Wang , Lingdong Kong , Ziping Zhao

Spatial transcriptomics enables simultaneous measurement of gene expression and tissue morphology, offering unprecedented insights into cellular organization and disease mechanisms. However, the field lacks comprehensive benchmarks for…

Gene expression profiling technologies have been used in various applications such as cancer biology. The development of gene expression profiling has expanded the scope of target discovery in transcriptomic studies, and each technology…

Genomics · Quantitative Biology 2023-01-10 Hyeongseon Jeon , Juan Xie , Yeseul Jeon , Kyeong Joo Jung , Arkobrato Gupta , Won Chang , Dongjun Chung

In exploring Predictive Health Management (PHM) strategies for Proton Exchange Membrane Fuel Cells (PEMFC), the Transformer model, widely used in data-driven approaches, excels in many fields but struggles with time series analysis due to…

Machine Learning · Computer Science 2025-04-15 Zezhi Tang , Xiaoyu Chen , Xin Jin , Benyuan Zhang , Wenyu Liang

Understanding the dynamic nature of biological systems is fundamental to deciphering cellular behavior, developmental processes, and disease progression. Single-cell RNA sequencing (scRNA-seq) has provided static snapshots of gene…

Quantitative Methods · Quantitative Biology 2025-05-02 Zhenyi Zhang , Yuhao Sun , Qiangwei Peng , Tiejun Li , Peijie Zhou

Recently developed technologies to generate single-cell genomic data have made a revolutionary impact in the field of biology. Multi-omics assays offer even greater opportunities to understand cellular states and biological processes.…

Genomics · Quantitative Biology 2022-01-19 Stefan Stanojevic , Yijun Li , Lana X. Garmire

Spatial Transcriptomics (ST) is a method that captures gene expression profiles aligned with spatial coordinates. The discrete spatial distribution and the super-high dimensional sequencing results make ST data challenging to be modeled…

Machine Learning · Computer Science 2025-05-08 Qingtian Zhu , Yumin Zheng , Yuling Sang , Yifan Zhan , Ziyan Zhu , Jun Ding , Yinqiang Zheng