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The quadratic complexity of standard self-attention severely limits the application of Transformer-based models to long-context tasks. While efficient Transformer variants exist, they often require architectural changes and costly…

Computation and Language · Computer Science 2025-11-14 Jiangshu Du , Wenpeng Yin , Philip Yu

Intracranial recordings have opened a unique opportunity to simultaneously measure activity across multiregional networks in the human brain. Recent works have focused on developing transformer-based neurofoundation models of such…

Machine Learning · Computer Science 2025-12-16 Lucine L. Oganesian , Saba Hashemi , Maryam M. Shanechi

To analyze the scaling potential of deep tabular representation learning models, we introduce a novel Transformer-based architecture specifically tailored to tabular data and cross-table representation learning by utilizing table-specific…

Machine Learning · Computer Science 2023-10-02 Maximilian Schambach , Dominique Paul , Johannes S. Otterbach

We present Token-UNet, adopting the TokenLearner and TokenFuser modules to encase Transformers into UNets. While Transformers have enabled global interactions among input elements in medical imaging, current computational challenges hinder…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Louis Fabrice Tshimanga , Andrea Zanola , Federico Del Pup , Manfredo Atzori

Understanding how information propagates through Transformer models is a key challenge for interpretability. In this work, we study the effects of minimal token perturbations on the embedding space. In our experiments, we analyze the…

Machine Learning · Computer Science 2025-06-24 Eddie Conti , Alejandro Astruc , Alvaro Parafita , Axel Brando

The location, timing, and abundance of gene expression (both mRNA and proteins) within a tissue define the molecular mechanisms of cell functions. Recent technology breakthroughs in spatial molecular profiling, including imaging-based…

Applications · Statistics 2020-12-10 Qiwei Li , Minzhe Zhang , Yang Xie , Guanghua Xiao

Single-cell sequencing technology maps cells to a high-dimensional space encoding their internal activity. Recently-proposed virtual cell models extend this concept, enriching cells' representations based on patterns learned from…

Quantitative Methods · Quantitative Biology 2025-11-03 William Gilpin

Single-cell RNA sequencing (scRNA-seq) allows transcriptional profiling, and cell-type annotation of individual cells. However, sample preparation in typical scRNA-seq experiments often homogenizes the samples, thus spatial locations of…

Applications · Statistics 2024-08-28 Junhao Zhu , Kevin Zhang , Dehan Kong , Zhaolei Zhang

Spatial transcriptomics has revolutionized tissue analysis by simultaneously mapping gene expression, spatial topography, and histological context across consecutive tissue sections, enabling systematic investigation of spatial…

Applications · Statistics 2025-10-24 Meng Zhou , Shuangge Ma , Mengyun Wu

With the emergence of advanced spatial transcriptomic technologies, there has been a surge in research papers dedicated to analyzing spatial transcriptomics data, resulting in significant contributions to our understanding of biology. The…

Genomics · Quantitative Biology 2024-04-11 Sikta Das Adhikari , Jiaxin Yang , Jianrong Wang , Yuehua Cui

Spatial transcriptomics has the potential to transform our understanding of RNA expression in tissues. Classical array-based technologies produce multiple-cell-scale measurements requiring deconvolution to recover single cell information.…

Convolutional Neural Networks define an exceptionally powerful class of models, but are still limited by the lack of ability to be spatially invariant to the input data in a computationally and parameter efficient manner. In this work we…

Computer Vision and Pattern Recognition · Computer Science 2016-02-05 Max Jaderberg , Karen Simonyan , Andrew Zisserman , Koray Kavukcuoglu

Genomics methods have uncovered patterns in a range of biological systems, but obscure important aspects of cell behavior: the shape, relative locations of, movement of, and interactions between cells in space. Spatial technologies that…

Applications · Statistics 2023-10-17 Siddhartha G Jena , Archit Verma , Barbara E Engelhardt

Phenotypic drug discovery has attracted widespread attention because of its potential to identify bioactive molecules. Transcriptomic profiling provides a comprehensive reflection of phenotypic changes in cellular responses to external…

Machine Learning · Computer Science 2025-01-16 Hui Liu , Shikai Jin

Spatio-temporal sensor data in real-world systems is often sparse, noisy, and irregular, making latent field reconstruction fundamentally underconstrained. Under extreme sparsity, multiple physically plausible fields may remain consistent…

Machine Learning · Computer Science 2026-05-20 Ankit Bhardwaj , Ananth Balashankar , Lakshminarayanan Subramanian

Accurate medical time series (MedTS) classification is essential for effective clinical diagnosis, yet remains challenging due to complex multi-channel temporal dependencies, information redundancy, and label scarcity. While…

Machine Learning · Computer Science 2025-08-19 Jiexia Ye , Weiqi Zhang , Ziyue Li , Jia Li , Fugee Tsung

Transformers have demonstrated remarkable performance in natural language processing and computer vision. However, existing vision Transformers struggle to learn from limited medical data and are unable to generalize on diverse medical…

Image and Video Processing · Electrical Eng. & Systems 2023-04-06 Yunhe Gao , Mu Zhou , Di Liu , Zhennan Yan , Shaoting Zhang , Dimitris N. Metaxas

Accurate detection of cancer tissue regions (CTR) enables deeper analysis of the tumor microenvironment and offers crucial insights into treatment response. Traditional CTR detection methods, which typically rely on the rich cellular…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Shuailin Xue , Jun Wan , Lihua Zhang , Wenwen Min

Although Transformers-based architectures excel at processing textual information, their naive adaptation for tabular data often involves flattening the table structure. This simplification can lead to the loss of essential…

Computation and Language · Computer Science 2025-03-04 Raphaël Mouravieff , Benjamin Piwowarski , Sylvain Lamprier

As the global need for large-scale data storage is rising exponentially, existing storage technologies are approaching their theoretical and functional limits in terms of density and energy consumption, making DNA based storage a potential…

Emerging Technologies · Computer Science 2021-10-12 Yotam Nahum , Eyar Ben-Tolila , Leon Anavy