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Purpose: Machine learning is broadly used for clinical data analysis. Before training a model, a machine learning algorithm must be selected. Also, the values of one or more model parameters termed hyper-parameters must be set. Selecting…

Machine Learning · Computer Science 2018-12-10 Xueqiang Zeng , Gang Luo

Automaton models are often seen as interpretable models. Interpretability itself is not well defined: it remains unclear what interpretability means without first explicitly specifying objectives or desired attributes. In this paper, we…

Machine Learning · Statistics 2016-11-28 Christian Albert Hammerschmidt , Sicco Verwer , Qin Lin , Radu State

The effectiveness of the machine learning methods for real-world tasks depends on the proper structure of the modeling pipeline. The proposed approach is aimed to automate the design of composite machine learning pipelines, which is…

Many prescriptive approaches to developing software intensive systems have been advocated but each is based on assumptions about context. It has been found that practitioners do not follow prescribed methodologies, but rather select and…

Software Engineering · Computer Science 2021-01-01 Diana Kirk , Stephen G. MacDonell , Ewan Tempero

Agent-based models (ABMs) are ubiquitous in research and industry. Currently, simulating ABMs involves at least some imperative (step-by-step) computer instructions. An alternative approach is declarative programming, in which a set of…

Multiagent Systems · Computer Science 2015-04-01 David Bruce Borenstein

Modern life sciences research is increasingly relying on artificial intelligence approaches to model biological systems, primarily centered around the use of machine learning (ML) models. Although ML is undeniably useful for identifying…

This paper surveys foundation models for AI-enabled biological design, focusing on recent developments in applying large-scale, self-supervised models to tasks such as protein engineering, small molecule design, and genomic sequence design.…

Artificial Intelligence · Computer Science 2025-05-20 Asher Moldwin , Amarda Shehu

Recently developed pretrained models can encode rich world knowledge expressed in multiple modalities, such as text and images. However, the outputs of these models cannot be integrated into algorithms to solve sequential decision-making…

Artificial Intelligence · Computer Science 2024-06-19 Yunhao Yang , Cyrus Neary , Ufuk Topcu

Like other types of computational research, modeling and simulation of biological processes (biomodels) is still largely communicated without sufficient detail to allow independent reproduction of results. But reproducibility in this area…

Other Quantitative Biology · Quantitative Biology 2023-04-19 Pedro Mendes

Knowledge-based or Artificial Intelligence techniques are used increasingly as alternatives to more classical techniques to model ENVIRONMENTAL SYSTEMS. Use of Artificial Intelligence (AI) in environmental modelling has increased with…

Artificial Intelligence · Computer Science 2014-09-16 Kamran Latif

Equipping machines with comprehensive knowledge of the world's entities and their relationships has been a long-standing goal of AI. Over the last decade, large-scale knowledge bases, also known as knowledge graphs, have been automatically…

Artificial Intelligence · Computer Science 2021-12-07 Gerhard Weikum , Luna Dong , Simon Razniewski , Fabian Suchanek

Increasingly sophisticated experiments, coupled with large-scale computational models, have the potential to systematically test biological hypotheses to drive our understanding of multicellular systems. In this short review, we explore key…

Quantitative Methods · Quantitative Biology 2019-10-28 Paul Macklin

Biological systems are often modelled at different levels of abstraction depending on the particular aims/resources of a study. Such different models often provide qualitatively concordant predictions over specific parametrisations, but it…

Machine Learning · Statistics 2016-05-10 Giulio Caravagna , Luca Bortolussi , Guido Sanguinetti

We propose a new approach to model composition, based on reducing several models to the same level of complexity and subsequent combining them together. Firstly, we suggest a set of model reduction tools that can be systematically applied…

Molecular Networks · Quantitative Biology 2013-10-24 Elena Kutumova , Andrei Zinovyev , Ruslan Sharipov , Fedor Kolpakov

With the rapid development of deep learning, there have been an unprecedentedly large number of trained deep network models available online. Reusing such trained models can significantly reduce the cost of training the new models from…

Computer Vision and Pattern Recognition · Computer Science 2018-12-04 Chengchao Shen , Xinchao Wang , Jie Song , Li Sun , Mingli Song

A trend across most areas where simulation-driven development is used is the ever increasing size and complexity of the systems under consideration, pushing established methods of modeling and simulation towards their limits. This paper…

Numerical Analysis · Mathematics 2019-09-04 Gerald Schweiger , Henrik Nilsson , Josef Schoeggl , Wolfgang Birk , Alfred Posch

Conversational information access is an emerging research area. Currently, human evaluation is used for end-to-end system evaluation, which is both very time and resource intensive at scale, and thus becomes a bottleneck of progress. As an…

Information Retrieval · Computer Science 2020-06-17 Shuo Zhang , Krisztian Balog

An entirely novel synthesis combines the applied cognitive psychology of a task analytic approach with a neural cell assembly perspective that models both brain and mind function during task performance; similar cell assemblies could be…

Human-Computer Interaction · Computer Science 2019-10-25 Dan Diaper , Chris Huyck

Advancements in simulation and formal methods-guided environment sampling have enabled the rigorous evaluation of machine learning models in a number of safety-critical scenarios, such as autonomous driving. Application of these environment…

Machine Learning · Computer Science 2023-03-31 Ameesh Shah , Jonathan DeCastro , John Gideon , Beyazit Yalcinkaya , Guy Rosman , Sanjit A. Seshia

High-quality data is essential for conversational recommendation systems and serves as the cornerstone of the network architecture development and training strategy design. Existing works contribute heavy human efforts to manually labeling…

Computation and Language · Computer Science 2023-06-19 Yu Lu , Junwei Bao , Zichen Ma , Xiaoguang Han , Youzheng Wu , Shuguang Cui , Xiaodong He