Related papers: Some reflections on the test-negative design
We investigated the negative relationship between mortality and COVID-19 vaccination at ecological level, which has been established through clinical trials and other investigations at the individual level. We conducted an exploratory,…
We develop a model of infection spread that takes into account the existence of a vulnerable group as well as the variability of the social relations of individuals. We develop a compartmentalized power-law model, with power-law connections…
Vaccination is important to minimize the risk and spread of various diseases. In recent years, vaccination has been a key step in countering the COVID-19 pandemic. However, many people are skeptical about the use of vaccines for various…
The COVID-19 pandemic has profoundly affected the normal course of life -- from lock-downs and virtual meetings to the unprecedentedly swift creation of vaccines. To halt the COVID-19 pandemic, the world has started preparing for the global…
Adaptive experimental design methods are increasingly being used in industry as a tool to boost testing throughput or reduce experimentation cost relative to traditional A/B/N testing methods. This paper shares lessons learned regarding the…
In this paper we introduce a compartmental epidemic model describing the transmission of the COVID-19 disease in presence of non-mandatory vaccination. The model takes into account the hesitancy and refusal of vaccination. To this aim, we…
We consider the problem of deciding how best to target and prioritize existing vaccines that may offer protection against new variants of an infectious disease. Sequential experiments are a promising approach; however, challenges due to…
The COVID-19 vaccine reduces infection risk: even if one contracts COVID-19, the probability of complications like death or hospitalization is lower. However, vaccination may prompt people to decrease preventive behaviors, such as staying…
The COVID-19 pandemic has adversely affected US public health, resulting in over a hundred million cases and more than one million deaths. Vaccination is the key intervention against the COVID-19 pandemic. Multiple COVID-19 vaccines are now…
Some problems of testology are discussed.
In narrative synthesis of evidence, it can be the case that the only quantitative measures available concerning the efficacy of an intervention is the direction of the effect, i.e. whether it is positive or negative. In such situations, the…
Available data on measured observables allow deriving estimates for some of the phenomenological parameters that characterize the time-evolution and decay of the neutral kaon system based on the hypothesis of complete positivity. The…
The aim of this paper is to review methods of designing screening experiments, ranging from designs originally developed for physical experiments to those especially tailored to experiments on numerical models. The strengths and weaknesses…
The SARS-CoV-2 virus and COVID-19 disease have posed unprecedented and overwhelming demand, challenges and opportunities to domain, model and data driven modeling. This paper provides a comprehensive review of the challenges, tasks,…
The COVID-19 pandemic fueled one of the most rapid vaccine developments in history. However, misinformation spread through online social media often leads to negative vaccine sentiment and hesitancy. To investigate COVID-19 vaccine-related…
COVID-19 vaccines are highly efficacious at preventing symptomatic infection, severe disease, and death. Most of the evidence that COVID-19 vaccines also reduce transmission of SARS-CoV-2 is based on retrospective, observational studies.…
Clinical trials are pivotal in the drug discovery process to determine the safety and efficacy of a drug candidate. The high failure rates of these trials are attributed to deficiencies in clinical model development and protocol design.…
Healthcare workers such as doctors and nurses are expected to be trustworthy and creditable sources of vaccine-related information. Their opinions toward the COVID-19 vaccines may influence the vaccine uptake among the general population.…
Over 12 billion doses of COVID-19 vaccines have been administered at the time of writing. However, public perceptions of vaccines have been complex. We analyzed COVID-19 vaccine-related tweets to understand the evolving perceptions of…
The study in group testing aims to develop strategies to identify a small set of defective items among a large population using a few pooled tests. The established techniques have been highly beneficial in a broad spectrum of applications…