Related papers: Some reflections on the test-negative design
Safe and effective preventive vaccines have the potential to help stem the HIV epidemic. The efficacy of such vaccines is typically measured in randomized, double-blind phase IIb/III trials and described as a reduction in newly acquired HIV…
The time when everyone is struggling in the cruel hands of COVID19, we present the holistic view on the effects of this pandemic in certain aspects of life. A lot of literature exists in COVID-19, but most of them talk about the social and…
The massive shock of the COVID-19 pandemic is already showing its negative effects on economies around the world, unprecedented in recent history. COVID-19 infections and containment measures have caused a general slowdown in research and…
Testing is an important part of tackling the COVID-19 pandemic. Availability of testing is a bottleneck due to constrained resources and effective prioritization of individuals is necessary. Here, we discuss the impact of different…
It is widely believed that quantum key distribution (QKD) has been proved unconditionally secure for realistic models applicable to various current experimental schemes. Here we summarize briefly why this is not the case, from both the…
The COVID-19 pandemic has presented significant challenges to the healthcare industry and society as a whole. With the rapid development of COVID-19 vaccines, social media platforms have become a popular medium for discussions on…
Adaptive designs for clinical trials permit alterations to a study in response to accumulating data in order to make trials more flexible, ethical and efficient. These benefits are achieved while preserving the integrity and validity of the…
We analyze mathematical models for COVID-19 with discrete time delays and vaccination. Sufficient conditions for the local stability of the endemic and disease-free equilibrium points are proved for any positive time delay. The stability…
Negative sampling approaches are prevalent in implicit collaborative filtering for obtaining negative labels from massive unlabeled data. As two major concerns in negative sampling, efficiency and effectiveness are still not fully achieved…
Over the past 150 years, vaccines have revolutionized the relationship between people and disease. During the COVID-19 pandemic, technologies such as mRNA vaccines have received attention due to their novelty and successes. However, more…
Polarization of opinions about vaccination can have a negative impact on pandemic control. In this work we quantify this negative impact for the transmission of COVID-19, using an agent based simulation in an heterogeneous population with…
This report reviews knowledge of the tranmission of COVID-19 indoors, reviews mitigating measures, and considers the implications for winter 2020.
I review some recent results showing that the physics of negative energy densities, as predicted by relativistic quantum field theories, is more complicated than has generally been appreciated. On the one hand, in external potentials where…
Adaptive Phase 2/3 designs hold great promise in contemporary oncology drug development, especially when limited data from Phase 1 dose-finding is insufficient for identifying an optimal dose. However, there is a general concern about…
Governments and businesses worldwide deployed a variety of technological measures to help prevent and track the spread of COVID-19. In Australia, these applications contained usability, accessibility, and security flaws that hindered their…
The problem of quantum test is formally addressed. The presented method attempts the quantum role of classical test generation and test set reduction methods known from standard binary and analog circuits. QuFault, the authors software…
We explore the possibility of testing the quantum nature of the gravitational field with an ensemble of ultra-cold atoms. The use of many microscopic particles may circumvent some of the experimental obstacles encountered in recent…
Misinformation promotes distrust in science, undermines public health, and may drive civil unrest. Vaccine misinformation, in particular, has stalled efforts to overcome the COVID-19 pandemic, prompting social media platforms' attempts to…
The theory of computer viruses has been studied by several authors, though there is no systematic theoretical study up to now. The long time open question in this area is as follows: Is it possible to design a signature-free (including…
Regular factorial designs with randomization restrictions are widely used in practice. This paper provides a unified approach to the construction of such designs using randomization defining contrast subspaces for the representation of…