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Estimating the effects of interventions on patient outcome is one of the key aspects of personalized medicine. Their inference is often challenged by the fact that the training data comprises only the outcome for the administered treatment,…

Machine learning models based on temporal point processes are the state of the art in a wide variety of applications involving discrete events in continuous time. However, these models lack the ability to answer counterfactual questions,…

Machine Learning · Computer Science 2022-05-23 Kimia Noorbakhsh , Manuel Gomez Rodriguez

Treatment strategies are critical in healthcare, particularly when outcomes are subject to censoring. This study introduces the Counterfactual Buckley-James Q-Learning framework, which integrates the Buckley-James method with reinforcement…

Methodology · Statistics 2025-08-18 Jeongjin Lee , Jong-Min Kim

Individual treatment effect (ITE) represents the expected improvement in the outcome of taking a particular action to a particular target, and plays important roles in decision making in various domains. However, its estimation problem is…

Machine Learning · Computer Science 2020-05-12 Shonosuke Harada , Hisashi Kashima

Clinical trials involving multiple treatments utilize randomization of the treatment assignments to enable the evaluation of treatment efficacies in an unbiased manner. Such evaluation is performed in post hoc studies that usually use…

Artificial Intelligence · Computer Science 2018-09-10 Yogatheesan Varatharajah , Brent Berry , Sanmi Koyejo , Ravishankar Iyer

Machine learning models, particularly deep neural networks, have demonstrated strong performance in classifying complex time series data. However, their black-box nature limits trust and adoption, especially in high-stakes domains such as…

Machine Learning · Computer Science 2025-12-23 Justin Li , Efe Sencan , Jasper Zheng Duan , Vitus J. Leung , Stephen Tsaur , Ayse K. Coskun

Machine-learning models are increasingly driving decisions in high-stakes settings, such as finance, law, and hiring, thus, highlighting the need for transparency. However, the key challenge is to balance transparency -- clarifying `why' a…

Artificial Intelligence · Computer Science 2025-08-29 Sopam Dasgupta , Sadaf MD Halim , Joaquín Arias , Elmer Salazar , Gopal Gupta

Recent years have witnessed the rise of misinformation campaigns that spread specific narratives on social media to manipulate public opinions on different areas, such as politics and healthcare. Consequently, an effective and efficient…

Machine Learning · Computer Science 2022-10-17 Yizhou Zhang , Defu Cao , Yan Liu

We consider after-study statistical inference for sequentially designed experiments wherein multiple units are assigned treatments for multiple time points using treatment policies that adapt over time. Our goal is to provide inference…

Machine Learning · Statistics 2025-06-10 Raaz Dwivedi , Katherine Tian , Sabina Tomkins , Predrag Klasnja , Susan Murphy , Devavrat Shah

Counterfactual thinking describes a psychological phenomenon that people re-infer the possible results with different solutions about things that have already happened. It helps people to gain more experience from mistakes and thus to…

Machine Learning · Computer Science 2019-08-19 Yue Wang , Yao Wan , Chenwei Zhang , Lixin Cui , Lu Bai , Philip S. Yu

Interventional effects have been proposed as a solution to the unidentifiability of natural (in)direct effects under mediator-outcome confounders affected by the exposure. Such confounders are an intrinsic characteristic of studies with…

Methodology · Statistics 2022-03-30 Iván Díaz , Nicholas Williams , Kara E. Rudolph

Machine learning (ML) holds great potential for accurately forecasting treatment outcomes over time, which could ultimately enable the adoption of more individualized treatment strategies in many practical applications. However, a…

Machine Learning · Statistics 2023-06-08 Toon Vanderschueren , Alicia Curth , Wouter Verbeke , Mihaela van der Schaar

We study a new model where the potential outcomes, corresponding to the values of a (possibly continuous) treatment, are linked through common factors. The factors can be estimated using a panel of regressors. We propose a procedure to…

Econometrics · Economics 2024-01-09 Jad Beyhum

Machine learning is increasingly used to select which individuals receive limited-resource interventions in domains such as human services, education, development, and more. However, it is often not apparent what the right quantity is for…

Machine Learning · Computer Science 2025-03-20 Vibhhu Sharma , Bryan Wilder

We introduce causal inference reasoning to cross-over trials, with a focus on Thorough QT (TQT) studies. For such trials, we propose different sets of assumptions and consider their impact on the modelling strategy and estimation procedure.…

Methodology · Statistics 2022-05-31 Jeppe Ekstrand Halkjær Madsen , Thomas Scheike , Christian Pipper

We consider the task of causal imputation, where we aim to predict the outcomes of some set of actions across a wide range of possible contexts. As a running example, we consider predicting how different drugs affect cells from different…

Machine Learning · Statistics 2024-09-19 Alvaro Ribot , Chandler Squires , Caroline Uhler

Traffic crashes profoundly impede traffic efficiency and pose economic challenges. Accurate prediction of post-crash traffic status provides essential information for evaluating traffic perturbations and developing effective solutions.…

Machine Learning · Computer Science 2024-07-22 Shuang Li , Ziyuan Pu , Nan Zhang , Duxin Chen , Lu Dong , Daniel J. Graham , Yinhai Wang

Treatment effect estimation is essential for informed decision-making in many fields such as healthcare, economics, and public policy. While flexible machine learning models have been widely applied for estimating heterogeneous treatment…

Machine Learning · Computer Science 2025-09-29 Pascal Memmesheimer , Vincent Heuveline , Jürgen Hesser

Counterfactual inference enables clinicians to ask "what if" questions about patient outcomes, but standard methods assume feature independence and simultaneous modifiability -- assumptions violated by longitudinal clinical data. We…

Machine Learning · Computer Science 2026-02-25 Jingya Cheng , Alaleh Azhir , Jiazi Tian , Hossein Estiri

In recent years, precision treatment strategy have gained significant attention in medical research, particularly for patient care. We propose a novel framework for estimating conditional average treatment effects (CATE) in time-to-event…

Methodology · Statistics 2024-07-29 Runjia Li , Victor B. Talisa , Chung-Chou H. Chang
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