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The emergence of mutant lineages within a viral species has become a public health problem, as the existing treatments and drugs are usually more effective on the original lineages than in the mutant ones. The following manuscript presents…

In this paper, we describe a constrained Lagrangian and Hamiltonian formalism for the optimal control of nonholonomic mechanical systems. In particular, we aim to minimize a cost functional, given initial and final conditions where the…

Optimization and Control · Mathematics 2014-12-24 Anthony Bloch , Leonardo Colombo , Rohit Gupta , David Martin de Diego

The optimal control of epidemic-like stochastic processes is important both historically and for emerging applications today, where it can be especially important to include time-varying parameters that impact viral epidemic-like…

Optimization and Control · Mathematics 2017-10-02 Yingdong Lu , Mark S. Squillante , Chai Wah Wu

Here and in a follow-on paper, we consider a simple control problem in which the underlying dynamics depend on a parameter $a$ that is unknown and must be learned. In this paper, we assume that $a$ is bounded, i.e., that $|a| \le…

Optimization and Control · Mathematics 2023-09-20 Jacob Carruth , Maximilian F. Eggl , Charles Fefferman , Clarence W. Rowley

We consider a family of optimal control problems where the control variable is given by a boundary condition of Neumann type. This family is governed by parabolic variational inequalities of the second kind. We prove the strong convergence…

Analysis of PDEs · Mathematics 2013-09-20 Mahdi Boukrouche , Domingo A. Tarzia

This paper primarily focuses on the practical applications of optimal control theory for perturbed sweeping processes within the realm of robotics dynamics. By describing these models as controlled sweeping processes with pointwise control…

Optimization and Control · Mathematics 2024-05-16 Giovanni Colombo , Boris S. Mordukhovich , Dao Nguyen , Trang Nguyen , Norma Ortiz-Robinson

In this work, we focus on the analytical and numerical study of a mathematical model for brain tumors with radiotherapy influence. Under certain assumptions on the given data in the model, we prove existence and uniqueness of a weak…

Analysis of PDEs · Mathematics 2024-09-27 Marina Chugunova , Hangjie Ji , Roman Taranets , Nataliya Vasylyeva

Solving parabolic optimal control problems can be inherently challenging in the field of science and engineering, especially with constraints on the nonsmooth distributed control. Motivated by the extensive applicability of the alternating…

Optimization and Control · Mathematics 2026-03-03 Haiming Song , Jinda Yang , Yuran Yang , Jianhua Yuan

In this work, we investigate the optimal control problem for continuous-time Markov decision processes with the random impact of the environment. We provide conditions to show the existence of optimal controls under finite-horizon criteria.…

Optimization and Control · Mathematics 2020-06-23 Jinghai Shao , Kun Zhao

Achieving full control of the time-evolution of a many-body quantum system is currently a major goal in physics. In this work we investigate the different ways in which the controllability of a quantum system can be influenced by its…

Quantum Physics · Physics 2016-09-14 P. M. Poggi , D. A. Wisniacki

Mathematical modelling can help to explain the nature and dynamics of infection transmissions, as well as support a policy for implementing those strategies that are most likely to bring public health and economic benefits. The paper…

Optimization and Control · Mathematics 2015-09-01 Roman Denysiuk , Cristiana J. Silva , Delfim F. M. Torres

This paper is devoted to the controllability of a general linear hyperbolic system in one space dimension using boundary controls on one side. Under precise and generic assumptions on the boundary conditions on the other side, we previously…

Optimization and Control · Mathematics 2019-10-29 Jean-Michel Coron , Hoai-Minh Nguyen

A class of optimal control problems of hybrid nature governed by semilinear parabolic equations is considered. These problems involve the optimization of switching times at which the dynamics, the integral cost, and the bounds on the…

Optimization and Control · Mathematics 2016-11-30 Sébastien Court , Karl Kunisch , Laurent Pfeiffer

An optimal control problem on finite-dimensional positive cones is stated. Under a critical assumption on the cone, the corresponding Bellman equation is satisfied by a linear function, which can be computed by convex optimization. A…

Optimization and Control · Mathematics 2024-10-02 Richard Pates , Anders Rantzer

This work addresses controllability properties for some systems of partial differential equations in which the main feature is the coupling through nonlocal integral terms. In the first part, we study a nonlinear parabolic-elliptic system…

Analysis of PDEs · Mathematics 2023-12-07 Kuntal Bhandari , Víctor Hernández-Santamaría

In this paper we introduce the optimal control of a kinetic model describing agents who migrate on a graph and interact within its nodes exchanging a physical quantity. As a prototype model, we consider the spread of an infectious disease…

Optimization and Control · Mathematics 2026-01-15 Jonathan Franceschi , Nadia Loy

One of the most promising strategies to treat cancer is attacking it with viruses designed to exploit specific altered pathways. Here, the effects of oncolytic virotherapy on tumors having compact, papillary and disconnected morphologies…

Biological Physics · Physics 2011-09-19 L R Paiva , M L Martins , S C Ferreira

Reaction-diffusion systems offer a powerful framework for understanding self-organized patterns in biological systems, yet controlling these patterns remains a significant challenge. As a consequence, we present a rigorous framework of…

Optimization and Control · Mathematics 2026-04-13 Mohamed Amine Ouchdiri , Hamza Faquir , Saad Benjelloun , Mohamed Adlene Maghenem , Irene Otero-Muras , Adnane Saoud

The aim of this paper is to provide a rigorous mathematical analysis of an optimal control problem with SIR dynamics. The main feature of our study is the presence of state constraints (related to intensive care units ICU capacity) and…

Optimization and Control · Mathematics 2021-08-25 Florin Avram , Lorenzo Freddi , Dan Goreac

In this study, we theoretically analyzed a control protocol based on ``time-dependent resonance" in nearly adiabatic two-level quantum systems, demonstrating that it exhibits properties equivalent to adiabatic control. This protocol is…

Quantum Physics · Physics 2025-01-03 Takayuki Suzuki
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