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We developed simulation methodology to assess eventual therapeutic efficiency of exogenous multiparametric changes in a four-component cellular system described by the system of ordinary differential equations. The method is numerically…

Tissues and Organs · Quantitative Biology 2018-06-05 Denis Horváth , Branislav Brutovsky

We present a unified treatment to control problems on an arbitrary time scale by introducing the study of forward-backward optimal control problems. Necessary optimality conditions for delta-nabla isoperimetric problems are proved, and…

Optimization and Control · Mathematics 2011-10-17 Ewa Girejko , Agnieszka B. Malinowska , Delfim F. M. Torres

In this paper, we consider the stochastic optimal control problem for the interacting particle system. We obtain the stochastic maximum principle of the optimal control system by introducing a generalized backward stochastic differential…

Probability · Mathematics 2025-05-14 Andrey A. Dorogovtsev , Yuecai Han , Kateryna Hlyniana , Yuhang Li

In this note, we consider the existence and uniqueness of the solution of a time-dependent optimal control problem constrained by a partial differential equation with uncertain inputs. Relying on the Lions' Lemma for deterministic problems,…

Optimization and Control · Mathematics 2018-10-04 Peter Benner , Akwum Onwunta , Martin Stoll

The optimal time for the controllability of linear hyperbolic systems in one dimensional space with one-side controls has been obtained recently for time-independent coefficients in our previous works. In this paper, we consider linear…

Optimization and Control · Mathematics 2021-03-05 Jean-Michel Coron , Hoai-Minh Nguyen

We consider a system that is exactly controllable. For given initial state, terminal state and objective function, an optimal control is often well-defined. Such an optimal control has the disadvantage that although it works perfectly well…

Optimization and Control · Mathematics 2013-07-08 Martin Gugat

Optimal control theory provides recipes to achieve quantum operations with high fidelity and speed, as required in quantum technologies such as quantum sensing and computation. While technical advances have achieved the ultrastrong driving…

Quantum Physics · Physics 2015-11-25 M. Hirose , P. Cappellaro

This work addresses an optimal control problem constrained by a degenerate kinetic equation of parabolic-hyperbolic type. Using a hypocoercivity framework we establish the well-posedness of the problem and demonstrate that the optimal…

Numerical Analysis · Mathematics 2024-12-17 Aaron Pim , Tristan Pryer , Alex Trenam

A theoretical framework and numerical techniques to solve optimal control problems with a spatial trace term in the terminal cost and governed by regularized nonlinear hyperbolic conservation laws are provided. Depending on the spatial…

Optimization and Control · Mathematics 2018-01-23 Sébastien Court , Karl Kunisch , Laurent Pfeiffer

This paper is concerned with the maximum principle of stochastic optimal control problems, where the coefficients of the state equation and the cost functional are uncertain, and the system is generally under Markovian regime switching.…

Optimization and Control · Mathematics 2025-04-15 Tao Hao , Jiaqiang Wen , Jie Xiong

The paper presents results about strong metric subregularity of the optimality mapping associated with the system of first-order necessary optimality conditions for a problem of optimal control of a semilinear parabolic equation. The…

Optimization and Control · Mathematics 2025-11-19 Alberto Domínguez Corella , Nicolai Jork , Vladimir M. Veliov

This paper investigates an optimal control problem associated with a two-dimensional multi-species Cahn-Hilliard-Keller-Segel tumor growth model, which incorporates complex biological processes such as species diffusion, chemotaxis,…

Analysis of PDEs · Mathematics 2024-07-26 Pierluigi Colli , Gianni Gilardi , Andrea Signori , Jürgen Sprekels

We apply optimal control theory to a tuberculosis model given by a system of ordinary differential equations. Optimal control strategies are proposed to minimize the cost of interventions. Numerical simulations are given using data from…

Optimization and Control · Mathematics 2012-07-23 Cristiana J. Silva , Delfim F. M. Torres

The control system in surgical robots must ensure patient safety and real time control. As such, all the uncertainties which could appear should be considered into an extended model of the plant. After such an uncertain plant is formed, an…

Robotics · Computer Science 2024-07-24 Vlad Mihaly , Iosif Birlescu , Mircea Şuşcă , Damien Chablat , Petru Dobra

We apply optimal control theory to a tuberculosis model given by a system of ordinary differential equations. Optimal control strategies are proposed to minimize the cost of interventions, considering reinfection and post-exposure…

Optimization and Control · Mathematics 2013-07-15 Cristiana J. Silva , Delfim F. M. Torres

This paper concerns a distributed optimal control problem for a tumor growth model of Cahn-Hilliard type including chemotaxis with possibly singular potentials, where the control and state variables are nonlinearly coupled. First, we…

Optimization and Control · Mathematics 2023-06-06 Pierluigi Colli , Andrea Signori , Jürgen Sprekels

In this paper, we consider a class of time-optimal control problems governed by linear parabolic equations with mixed control-state constraints and end-point constraints, and without Tikhonov regularization term in the objective function.…

Optimization and Control · Mathematics 2025-09-04 Huynh Khanh , Bui Trong Kien

The paper addresses the study of a class of evolutionary quasi-variational inequalities of the parabolic type arising in the formation and growth models of granular and cohensionless materials. Such models and their mathematical…

Optimization and Control · Mathematics 2022-09-02 Harbir Antil , Rafael Arndt , Boris S. Mordukhovich , Dao Nguyen , Carlos N. Rautenberg

We consider an optimal control problem where the state is governed by a free boundary problem called the two-phase membrane problem and the control appears in the coefficients of the characteristic function of the positivity and negativity…

Optimization and Control · Mathematics 2024-05-20 Farid Bozorgnia , Vyacheslav Kungurtsev

Inverse Stefan problem arising in modeling of laser ablation of biomedical tissues is analyzed, where information on the coefficients, heat flux on the fixed boundary, and density of heat sources are missing and must be found along with the…

Analysis of PDEs · Mathematics 2017-10-25 Ugur G. Abdulla , Jonathan Goldfarb