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Diffusing alpha-emitters radiation therapy (Alpha-DaRT) is a new modality that uses alpha particles to treat solid tumors. Alpha-DaRT employs interstitial sources loaded with low activities of Radium-224, which release a chain of…

Diffusing alpha-emitters Radiation Therapy (Alpha DaRT) enables the use of alpha particles for the treatment of solid tumors. It employs interstitial sources carrying a few uCi of Ra-224, designed to release its short-lived progeny, which…

Medical Physics · Physics 2023-11-16 Lior Epstein , Guy Heger , Arindam Roy , Israel Gannot , Itzhak Kelson , Lior Arazi

Alpha-DaRT is a new method for treating solid tumors with alpha particles, relying on the release of the alpha-emitting daughter atoms of radium-224 from sources inserted into the tumor. The most important model parameters for Alpha-DaRT…

Diffusing Alpha-emitters Radiation Therapy (DaRT) is a new method for treating solid tumors using alpha particles. Unlike conventional radiotherapy, where the physical models for dose calculations are known and routinely used, for DaRT a…

Medical Physics · Physics 2021-11-09 Guy Heger , Lior Arazi

Diffusing alpha-emitters Radiation Therapy ("Alpha DaRT") is a new treatment modality focusing on the use of alpha particles against solid tumors. The introduction of Alpha DaRT in clinical settings calls for the development of detailed…

Medical Physics · Physics 2025-11-04 Yevgeniya Korotinsky , Lior Arazi

Targeted alpha-particle therapy (TAT) employs alpha-emitting radionuclides conjugated to tumor-targeting molecules to deliver localized radiation to cancer cells, showing great promise in treating metastatic cancers. Among these…

Targeted Alpha Therapy potentially offers a more specific action in killing tumor cells and less damage to neighbouring normal cells compared to $\beta$-emitters. $^{225}$Ac along with three other $\alpha$-emitting daughter nuclei…

Medical Physics · Physics 2020-08-06 H. Kumawat , S. V. Suryanarayana

Natural radioactivity concentrations in high exposure building materials are commonly used in Iran, which is measured a direct exposure by using {\gamma}-ray spectrometry. The values for 226Ra, 232Th and 40K were in the ranges 3.8 - 94.2,…

Nuclear Experiment · Physics 2016-04-26 Akbar Abbasi , Mustfa Hassanzadeh

Electrostatic spectrometers utilized in high-resolution beta-spectroscopy studies such as in the Karlsruhe Tritium Neutrino (KATRIN) experiment have to operate with a background level of less than 10^(-2) counts per second. This limit can…

Instrumentation and Detectors · Physics 2015-06-15 N. Wandkowsky , G. Drexlin , F. M. Fränkle , F. Glück , S. Groh , S. Mertens

Depth distributions of positron-emitting nuclei in PMMA phantoms are calculated within a Monte Carlo model for Heavy-Ion Therapy (MCHIT) based on the GEANT4 toolkit (version 8.0). The calculated total production rates of $^{11}$C, $^{10}$C…

Medical Physics · Physics 2007-05-23 Igor Pshenichnov , Igor Mishustin , Walter Greiner

We study the energy deposition by light and heavy nuclei in tissue-like media as used for cancer therapy. The depth-dose distributions for protons, $^{3}$He, $^{12}$C, $^{20}$Ne, and $^{58}$Ni nuclei are calculated within a Monte Carlo…

Medical Physics · Physics 2010-11-03 Igor Pshenichnov , Igor Mishustin , Walter Greiner

Dose distribution (depthwise and laterally) to organs outside the radiotherapy treatment field can be significant and therefore is of clinical interest from the radiation protection point of view. In the present work, measurements were…

Medical Physics · Physics 2012-03-19 Md. Farid Ahmed , S. Roy , G. U. Ahmed , F. K. Miah

The decay of common radioactive gases, such as radon, produces stable isotopes by a sequence of daughter particles with varied half-lives. These daughter particles are a significant source of gamma, neutron, and alpha particle backgrounds…

Instrumentation and Detectors · Physics 2015-09-02 M. Bruemmer , M. Nakib , R. Calkins , J. Cooley , S. Sekula

Targeted Radionuclide Therapy (TRT) is a well-established technique for cancer treatment. In this approach, radionuclides are bound to specific drugs that selectively transport them to the tumor site. Within the ISOLPHARM project, a…

We study energy deposition by light nuclei in tissue-like media taking into account nuclear fragmentation reactions, in particular, production of secondary neutrons. The calculations are carried out within a Monte Carlo model for Heavy-Ion…

Medical Physics · Physics 2007-05-23 Igor Pshenichnov , Igor Mishustin , Walter Greiner

An analytical equation for calculating radial dose of heavy ions in water is introduced by Awad et al. (Applied Radiation and Isotopes, 142 (2018) 135-142. It is simple alternative to Monte Carlo code and is a promising code, however, still…

Instrumentation and Detectors · Physics 2019-09-26 E. M. Awad a , M. Abu-Shady

A new method of experimental verification of radial dose distribution models using solid state thermoluminescent (TL) detectors LiF:Mg,Cu,P has been recently proposed. In this work the method was applied to verify the spatial distribution…

Instrumentation and Detectors · Physics 2014-01-28 W. Gieszczyk , P. Bilski , P. Olko , B. Obryk

Background: The epidemiology of the slightly radioactive contrast agent named Thorotrast presents a very long latency period between the injection and the development of the related pathologies. It is an example of the more general problem…

Medical Physics · Physics 2014-03-24 Andrea Bianconi

In 2006 Mom\v{c}ilovi\'c et al. measured radioactvity levels of 210Po and 210Bi by alpha- and beta-measurements resp. to determine the natural distribuion of environmental radon daughters in the different brain areas of an Alzheimer Disease…

Medical Physics · Physics 2018-06-26 Michael S. Pravikoff , Christine Marquet , Philippe Hubert

Polyethylene and copper samples were exposed to the underground air at SNOLAB for approximately three months while several environmental factors were monitored. Predictions of the radon-daughter plate-out rate are compared to the resulting…

Instrumentation and Methods for Astrophysics · Physics 2017-11-15 Matthew Stein , Dan Bauer , Ray Bunker , Rob Calkins , Jodi Cooley , Ben Loer , Silvia Scorza
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