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Tanker water systems play critical role in providing adequate service to meet potable water demands in the face of acute water crisis in many cities globally. Managing tanker movements among the supply and demand sides requires an efficient…

Optimization and Control · Mathematics 2024-08-02 Abhilasha Maheshwari , Shamik Misra , Ravindra Gudi , Senthilmurugan Subbiah , Chrysi Laspidou

The creation of nurses' schedules is a critical task that directly impacts the quality and safety of patient care as well as the quality of life for nurses. In most hospitals in Japan, this responsibility falls to the head nurse of each…

Optimization and Control · Mathematics 2025-07-08 Keisuke Nakashima , Kohei Furuike , Yoshiaki Inoue

The effects of molecularly targeted drug perturbations on cellular activities and fates are difficult to predict using intuition alone because of the complex behaviors of cellular regulatory networks. An approach to overcoming this problem…

Systems and Control · Computer Science 2019-01-15 Afroza Shirin , Isaac Klickstein , Song Feng , Yen Ting Lin , William S. Hlavacek , Francesco Sorrentino

In this paper, a nurse-scheduling model is developed using mixed integer programming model. It is deployed to a general care ward to replace and automate the current manual approach for scheduling. The developed model differs from other…

Data Structures and Algorithms · Computer Science 2012-10-16 Murphy Choy , Michelle Cheong

The City of Toronto Long Term Care Homes & Services (LTCH&S) division is one of the largest providers of long-term care in the Canadian province of Ontario, providing care to 2,640 residents at 10 homes across Toronto. Our collaboration…

Computers and Society · Computer Science 2021-02-19 Manion Anderson , Merve Bodur , Scott Rathwell , Vahid Sarhangian

Assigning patients to rooms and nurses to patients are critical tasks within hospitals that directly affect patient and staff satisfaction, quality of care, and hospital efficiency. Both patient-to-room assignments and nurse-to-patient…

Chemotherapy is a class of cancer treatment that uses drugs to kill cancer cells. A typical chemotherapeutic protocol consists of several drugs delivered in cycles of three weeks. We present mathematical analyses demonstrating the existence…

Populations and Evolution · Quantitative Biology 2017-06-26 Alvaro G. Lopez , Kelly C. Iarosz , Antonio M. Batista , Jesus M. Seoane , Ricardo L. Viana , Miguel A. F. Sanjuan

The distributed operating room (OR) scheduling problem aims to find an assignment of surgeries to ORs across collaborating hospitals that share their waiting lists and ORs. We propose a stochastic extension of this problem where surgery…

Optimization and Control · Mathematics 2020-10-06 Cheng Guo , Merve Bodur , Dionne M. Aleman , David R. Urbach

When managing an organization, planners often encounter numerous challenging scenarios. In such instances, relying solely on intuition or managerial experience may not suffice, necessitating a quantitative approach. This demand is further…

Computers and Society · Computer Science 2024-07-17 Jubin Thomas

Radiotherapy represents an important phase of treatment for a large number of cancer patients. It is essential that resources used to deliver this treatment are employed effectively. This paper presents a new integer linear programming…

Computational Engineering, Finance, and Science · Computer Science 2011-03-18 Edmund K. Burke , Pedro Leite-Rocha , Sanja Petrovic

The move towards personalized treatment and digital twins for cancer therapy requires a complete understanding of the mathematical models upon which these optimized simulation-based strategies are formulated. This study investigates the…

Quantitative Methods · Quantitative Biology 2025-11-21 Changin Oh , Kathleen P. Wilkie

Interfractional geometric uncertainties can lead to deviations of the actual delivered dose from the prescribed dose distribution. To better handle these uncertainties during treatment, the authors propose a dynamic framework for robust…

Medical Physics · Physics 2019-05-16 Michelle Böck , Kjell Eriksson , Anders Forsgren

Scheduling of personnel in a hospital environment is vital to improving the service provided to patients and balancing the workload assigned to clinicians. Many approaches have been tried and successfully applied to generate efficient…

Artificial Intelligence · Computer Science 2019-10-21 David Landsman , Huiting Ma , Jesse Knight , Kevin Gough , Sharmistha Mishra

We consider the optimal appointment scheduling problem that incorporates patients' unpunctual behavior, where the unpunctuality is assumed to be time dependent, but additive. Our goal is to develop an optimal scheduling method for a large…

Optimization and Control · Mathematics 2024-12-30 Nikolai Lipscomb , Xin Liu , Vidyadhar G. Kulkarni

Nowadays, the increase in patient demand and the decline in resources are lengthening patient waiting times in many chemotherapy oncology departments. Therefore, enhancing healthcare services is necessary to reduce patient complaints.…

Computers and Society · Computer Science 2022-02-01 R. R. Corsini , A. Costa , S. Fichera , A. Pluchino

In this paper, a methodology is proposed that enables to analyze the sensitivity of the outcome of a therapy to unavoidable high dispersion of the patient specific parameters on one hand and to the choice of the parameters that define the…

Systems and Control · Electrical Eng. & Systems 2022-05-17 Mazen Alamir

A dynamic treatment regime is a sequence of medical decisions that adapts to the evolving clinical status of a patient over time. To facilitate personalized care, it is crucial to assess the probability of each available treatment option…

Methodology · Statistics 2024-11-05 Jiefeng Bi , Matteo Borrotti , Bernardo Nipoti

The aim is to create a method for accurately estimating the duration of post-cancer treatment, particularly focused on chemotherapy, to optimize patient care and recovery. This initiative seeks to improve the effectiveness of cancer…

Computers and Society · Computer Science 2025-04-24 Joyee Chakraborty , Mazahrul Islam Tohin , Danbir Rashid , Tanjil Ahmed Tanmoy , Md. Jehadul Islam Mony

We study the nurse staffing problem under random nurse demand and absenteeism. While the demand uncertainty is exogenous (stemming from the random patient census), the absenteeism uncertainty is \emph{endogenous}, i.e., the number of nurses…

Optimization and Control · Mathematics 2022-08-11 Minseok Ryu , Ruiwei Jiang

This study presents a mathematical model that captures the interactions among tumor cells, healthy cells, and immune cells in a tumor-bearing host, with a specific focus on breast cancer. Incorporating the concept of delay, the model…

Quantitative Methods · Quantitative Biology 2026-03-19 Fatemeh Ansarizadeh , Tonghua Zhang