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In spite of years of research, the mechanisms that underlie the development of schizophrenia, as well as its relapse, symptomatology, and treatment, continue to be a mystery. The absence of appropriate analytic tools to deal with the…

Computer Vision and Pattern Recognition · Computer Science 2022-10-12 Vigneshwaran Shankaran , Bhaskaran V

Currently self-report pain ratings are the gold standard in clinical pain assessment. However, the development of objective automatic measures of pain could substantially aid pain diagnosis and therapy. Recent neuroimaging studies have…

Image and Video Processing · Electrical Eng. & Systems 2019-07-31 Daniel Lopez-Martinez , Ke Peng , Arielle Lee , David Borsook , Rosalind Picard

Human brains lie at the core of complex neurobiological systems, where the neurons, circuits, and subsystems interact in enigmatic ways. Understanding the structural and functional mechanisms of the brain has long been an intriguing pursuit…

Neurons and Cognition · Quantitative Biology 2022-07-26 Hejie Cui , Wei Dai , Yanqiao Zhu , Xiaoxiao Li , Lifang He , Carl Yang

Clinical characterization and interpretation of respiratory sound symptoms have remained a challenge due to the similarities in the audio properties that manifest during auscultation in medical diagnosis. The misinterpretation and…

Systems and Control · Electrical Eng. & Systems 2021-10-18 Chinazunwa Uwaoma , Gunjan Mansingh

Osteoporosis is a common condition that increases fracture risk, especially in older adults. Early diagnosis is vital for preventing fractures, reducing treatment costs, and preserving mobility. However, healthcare providers face challenges…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Mehdi Hosseini Chagahi , Saeed Mohammadi Dashtaki , Niloufar Delfan , Nadia Mohammadi , Farshid Rostami Pouria , Behzad Moshiri , Md. Jalil Piran , Oliver Faust

Neuropsychiatric disorders, such as Alzheimer's disease (AD), depression, and autism spectrum disorder (ASD), are characterized by linguistic and acoustic abnormalities, offering potential biomarkers for early detection. Despite the promise…

Computation and Language · Computer Science 2025-12-25 Zhongren Dong , Haotian Guo , Weixiang Xu , Huan Zhao , Zixing Zhang

While Vision-Language Models (VLMs) have achieved notable progress in computational pathology (CPath), the gigapixel scale and spatial heterogeneity of Whole Slide Images (WSIs) continue to pose challenges for multimodal understanding.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Fengchun Liu , Songhan Jiang , Linghan Cai , Ziyue Wang , Yongbing Zhang

In this work, we study the problem pertaining to personalized classification of subclinical atherosclerosis by developing a hierarchical graph neural network framework to leverage two characteristic modalities of a patient: clinical…

Machine Learning · Computer Science 2025-09-15 Irsyad Adam , Steven Swee , Erika Yilin , Ethan Ji , William Speier , Dean Wang , Alex Bui , Wei Wang , Karol Watson , Peipei Ping

Mental health disorders, particularly cognitive disorders defined by deficits in cognitive abilities, are described in detail in the DSM-5, which includes definitions and examples of signs and symptoms. A simplified, machine-actionable…

Machine Learning · Computer Science 2025-11-26 Raoul H. Kutil , Georg Zimmermann , Barbara Strasser-Kirchweger , Christian Borgelt

Pathology foundation models (PFMs) have rapidly advanced and are becoming a common backbone for downstream clinical tasks, offering strong transferability across tissues and institutions. However, for dense prediction (e.g., segmentation),…

Image and Video Processing · Electrical Eng. & Systems 2026-02-05 Weiming Chen , Xitong Ling , Xidong Wang , Zhenyang Cai , Yijia Guo , Mingxi Fu , Ziyi Zeng , Minxi Ouyang , Jiawen Li , Yizhi Wang , Tian Guan , Benyou Wang , Yonghong He

Nearly one in five adolescents currently live with a diagnosed mental or behavioral health condition, such as anxiety, depression, or conduct disorder, underscoring the urgency of developing accurate and interpretable diagnostic tools.…

Machine Learning · Computer Science 2025-10-07 Song Wang , Zhenyu Lei , Zhen Tan , Jundong Li , Javier Rasero , Aiying Zhang , Chirag Agarwal

Histopathologic diagnosis relies on simultaneous integration of information from a broad range of scales, ranging from nuclear aberrations ($\approx \mathcal{O}(0.1{\mu m})$) through cellular structures ($\approx \mathcal{O}(10{\mu m})$) to…

Image and Video Processing · Electrical Eng. & Systems 2021-02-23 Rüdiger Schmitz , Frederic Madesta , Maximilian Nielsen , Jenny Krause , René Werner , Thomas Rösch

Linguistic features have shown promising applications for detecting various cognitive impairments. To improve detection accuracies, increasing the amount of data or the number of linguistic features have been two applicable approaches.…

Computation and Language · Computer Science 2019-03-29 Zining Zhu , Jekaterina Novikova , Frank Rudzicz

Emotion plays a significant role in our daily life. Recognition of emotion is wide-spread in the field of health care and human-computer interaction. Emotion is the result of the coordinated activities of cortical and subcortical neural…

We propose an automatic method to estimate self-reported pain based on facial landmarks extracted from videos. For each video sequence, we decompose the face into four different regions and the pain intensity is measured by modeling the…

Computer Vision and Pattern Recognition · Computer Science 2022-09-20 Benjamin Szczapa , Mohamed Daoudi , Stefano Berretti , Pietro Pala , Alberto Del Bimbo , Zakia Hammal

It is widely accepted that information derived from analyzing speech (the acoustic signal) and language production (words and sentences) serves as a useful window into the health of an individual's cognitive ability. In fact, most…

Computation and Language · Computer Science 2019-11-06 Rohit Voleti , Julie M. Liss , Visar Berisha

Previous research on automatic pain estimation from facial expressions has focused primarily on "one-size-fits-all" metrics (such as PSPI). In this work, we focus on directly estimating each individual's self-reported visual-analog scale…

Computer Vision and Pattern Recognition · Computer Science 2017-08-17 Dianbo Liu , Fengjiao Peng , Andrew Shea , Ognjen , Rudovic , Rosalind Picard

Atypical Parkinsonian Disorders (APD), also known as Parkinson-plus syndrome, are a group of neurodegenerative diseases that include progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). In the early stages, overlapping…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Mengyu Li , Ingibjörg Kristjánsdóttir , Thilo van Eimeren , Kathrin Giehl , Lotta M. Ellingsen , the ASAP Neuroimaging Initiative

Foundation models (FMs) promise to extract unified representations that generalize across downstream tasks. They have emerged across fields, including electroencephalography (EEG), but it is less clear how effective they are in this…

Pain is a complex condition that affects a large portion of the population. Accurate and consistent evaluation is essential for individuals experiencing pain and supports the development of effective and advanced management strategies.…

Artificial Intelligence · Computer Science 2025-09-17 Stefanos Gkikas , Ioannis Kyprakis , Manolis Tsiknakis
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